Buy Exforge 5-10/160 mg Novartis Besylate, Valsartan

Ingredient: Amlodipine Besylate, Valsartan

Manufacturer: Novartis

Brand Name: Exforge

Category: Blood Pressure

Item price: Exforge 5/160 mg $0.64

Item price: Exforge 10/160 mg $0.75

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Pharmacodynamics

Exforge is a combination of 2 antihypertensive drugs with an additional mechanism for controlling blood pressure: amlodipine, a derivative of dihydropyridine, belongs to the class of “slow” calcium channel blockers (BMCC), valsartan belongs to the class of angiotensin II receptor antagonists. The combination of these components has a mutually complementary hypotensive effect, which leads to a more pronounced decrease in blood pressure compared with that on the background of monotherapy with each drug.

Amlodipine

Amlodipine, which is part of Exforge, inhibits the transmembrane intake of calcium ions in cardiomyocytes and vascular smooth muscle cells. The mechanism of the antihypertensive effect of amlodipine is associated with a direct relaxing effect on the smooth muscles of blood vessels, causing a decrease in OPSS and a decrease in blood pressure.

Characteristic

Combined antihypertensive drug containing active substances with a complementary mechanism for controlling blood pressure.

Indications Exforge

Arterial hypertension (for patients who are shown combination therapy).

Contraindications Exforge

Hypersensitivity to the components of the drug; pregnancy. The safety of Exforge use in patients with unilateral or bilateral renal artery stenosis or stenosis of a single kidney artery, in patients after recent kidney transplantation, as well as children and adolescents under 18 years of age, has not been established.

With caution, a drug is prescribed for impaired liver function (especially with obstructive diseases of the biliary tract); severe renal impairment (creatinine Cl <10 ml / min); patients with mitral or aortic stenosis, hypertrophic obstructive cardiomyopathy; with hyperkalemia, a deficiency in the body of sodium and / or a decrease in bcc.

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Exforge Use in pregnancy and children

Exforge, like any other drug that has a direct effect on the renin-angiotensin-aldosterone system (RAAS), should not be prescribed during pregnancy and women planning a pregnancy. If pregnancy is detected during Exforge treatment, the drug should be discontinued as soon as possible.

Patients of childbearing age should be informed of the possible risk to the fetus associated with the use of drugs that affect RAAS. Given the mechanism of action of angiotensin II receptor antagonists, the risk to the fetus cannot be ruled out. It is known that the appointment of ACE inhibitors that affect RAAS in pregnant women in the II and III trimesters leads to damage or death of the developing fetus.

According to a retrospective analysis, the use of ACE inhibitors in the first trimester of pregnancy was accompanied by the development of pathology of the fetus and newborn.

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With the unintended use of valsartan in pregnant women, cases of the development of spontaneous abortion, oligohydramnios and impaired renal function in newborns have been described. It is not known whether valsartan and / or amlodipine is excreted in breast milk. Since valsartan with breast milk is noted in experimental studies, it is not recommended to use Exforge during lactation (breastfeeding).