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Official websites use. Share sensitive information only on official, secure websites. Buprenorphine is the first medication to treat opioid use disorder OUD that can be prescribed or dispensed in physician offices, significantly increasing access to treatment. As with all medications used in treatment, buprenorphine should be prescribed as part of a comprehensive treatment plan that includes counseling and other services to provide patients with a whole-person approach. Buprenorphine offers several benefits to those with OUD and to others for whom treatment in an Opioid Treatment Clinic is not appropriate or is less convenient. Buprenorphine is an opioid partial agonist. It produces effects such as euphoria or respiratory depression at low to moderate doses. With buprenorphine, however, these effects are weaker than full opioid agonists such as methadone and heroin. When taken as prescribed, buprenorphine is safe and effective. To begin treatment, an OUD patient must abstain from using opioids for at least 12 to 24 hours and be in the early stages of opioid withdrawal. Patents with opioids in their bloodstream or who are not in the early stages of withdrawal, may experience acute withdrawal. After a patient has discontinued or greatly reduced their opioid use, no longer has cravings, and is experiencing few, if any, side effects, if needed, the dose of buprenorphine may be adjusted. Due to the long-acting agent of buprenorphine, once patients are stabilized, it may be possible to switch from every day to alternate-day dosing. The length of time a patient receives buprenorphine is tailored to meet the needs of each patient, and in some cases, treatment can be indefinite. To prevent possible relapse, individuals can engage in on-going treatment—with or without MOUD. Naloxone is added to buprenorphine to decrease the likelihood of diversion and misuse of the combination drug product. Patients who are considering buprenorphine for treatment should be sure they fully understand the medication and its side effects before they take the medication. Their health care practitioner or pharmacist can provide this information. Patients should tell their health care practitioner about any side effects that are bothersome or do not go away. Buprenorphine may be prescribed to women who are pregnant and have an OUD. Buprenorphine and methadone are considered the treatments of choice for OUD in pregnant and breastfeeding women. Learn more about naloxone and nalmefene. Learn about other medication options. For clinical questions or mentoring, contact pcssnow. Mono Bar Official websites use. Ellos escuchan. They Hear You. Scott M. Delphin-Rittmon, Ph. Neeraj Gandotra, M. Kurt John, Ed. Brian Altman, J. Anita Everett, M. Yngvild K. Olsen, M. Dennis Romero, M. CDR Karina D. Aguilar, Dr. Lynda M. Zeller, M. Kristie Brooks, M. Zayna Fulton, M. Solr Mobile Search. Share Buttons. Your browser is not supported. Main page content Title Buprenorphine. What is Buprenorphine? How Does Buprenorphine Work? Buprenorphine has unique pharmacological properties that: Diminish the effects of physical dependency to opioids, such as withdrawal symptoms and cravings Increase safety in cases of overdose Lower the potential for misuse Buprenorphine for Opioid Use Disorder To begin treatment, an OUD patient must abstain from using opioids for at least 12 to 24 hours and be in the early stages of opioid withdrawal. Use the following precautions when taking buprenorphine: Do not take other medications without first consulting your doctor. Do not use illegal drugs, drink alcohol, or take sedatives, tranquilizers, or other drugs that slow breathing. Mixing large amounts of other medications with buprenorphine can lead to overdose or death. Ensure that a physician monitors any liver-related health issues that you may have. Tell your doctor if you are pregnant or plan to become pregnant. Prevent children and pets from accidental Ingestion by storing it out of reach. Dispose of unused methadone safely. Talk to your MOUD practitioner for guidance, or for more information on the safe disposal of unused medications, visit FDA's disposal of unused medicines or DEA's drug disposal webpages Do not shared your buprenorphine with anyone even if they have similar symptoms or suffer from the same condition. Common and Serious Side Effects of Buprenorphine Patients who are considering buprenorphine for treatment should be sure they fully understand the medication and its side effects before they take the medication. Common side effects of buprenorphine include: Common side effects of buprenorphine include: Constipation, headache, nausea, and vomiting Dizziness Drowsiness and fatigue Sweating Dry mouth Tooth decay Muscle aches and cramps Inability to sleep Fever Blurred vision or dilated pupils Tremors Palpitations Disturbance in attention. Serious side effects of buprenorphine include: Serious side effects of buprenorphine include: Respiratory distress Overdose Adrenal insufficiency Dependence Withdrawal Itching, pain, swelling, and nerve damage implant Pain at injection site injection Neonatal abstinence syndrome in newborns. Tip Medications for Opioid Use Disorder Read More. Need Help? Buprenorphine Practitioner Locator - Find practitioners authorized to treat opioid dependency with buprenorphine by state. Opioid Overdose Reversal Medications. Buprenorphine Trainings. Other Medications for Substance Use Disorders. Contact Information. Last Updated.

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