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Background: Substance use disorder among adolescents considered a major problem worldwide that affects adolescents wellbeing and destroys their functionality socially, physically and psychologically. Findings: A final review of 9 studies that used quantitative and qualitative research methods to study many factors was related to the substance use disorder. Themes were: Influence of psychological factors on adolescents. Influence of socio-cultural factors on adolescents, the influence of biological factors on adolescents and the influence of environmental factors on adolescents. Conclusions: Reviewed articles revealed that many psychological, biological, socio-cultural, and environmental factors that increase adolescents risk having substance use disorder. For example, stressful life events during adolescents like loss of someone increase the risk to take illicit substances in order to forget painful memory; personal tendency like curiosity and experimentation, increase the risk to have risk health behaviors like substance use disorder. Furthermore, adolescence is a critical period that youth need more supervision and health education to protect them from Substance use disorder. Substance Use Disorder SUD is one of the difficult problems and considered a global health problem that increases the burden on families and governments, more than billion dollars dispensed on substance use yearly in USA \[1\] \[2\]. SUD is a self-destructive behavior that leads to a high incidence of early death; around 70, Americans died from drugs overdose in which increased every year \[3\]. However, a definite treatment for SUD not available yet \[4\]. There are a lot of therapeutic programs for rehabilitation only, but the relapse rate is still high \[1\]. Substance use disorder was generally defined as a misuse of illicit drugs or psychoactive substances like marijuana, hashish, and amphetamines which have a negative impact on individuals and those individuals have exacerbated desire to repeat take these substances \[4\] \[5\]. Many types of these substances are available now almost around ten separate classes of drugs: alcohol, caffeine, cannabis, hallucinogens, inhalants, opioids, sedatives, hypnotics or anxiolytics, stimulants, and tobacco use \[5\]. Substance use disorder is more common among adolescents, adolescent is a dynamic developmental period started from puberty until reach to social independence and ranged from 10 to 18 years and also from 18 - 21 years with variations according to some cultures and societies \[6\]. Physical, emotional, social and psychological changes occur during the adolescent stage. This changes make adolescents more vulnerable to health risk behaviors such as SUD \[6\] , for examples, adolescents like to separate from parents, like to take independent decision and responsibility, like to imitate and take adult roles and like to confirm their identity, for that reason, adolescents are risker than other ages to consume psychoactive substances or illegal drugs \[6\]. On the other hand, adolescents who do not have such protective factors are more likely to have health risk behaviors like substance use disorder. Therefore, the purpose of this review was to identify the factors that influence adolescents to have substance use disorder. Influencing factors: Factors that motivate the adolescent to consume harmful substances like marijuana and cocaine \[4\]. Causes of substance use disorder: Factors that inspire adolescents to have substance use disorder like family problems and loss of parents \[4\]. Cognitive development phase: is a process of change thinking from childhood like thinking to adulthood like thinking, during this period of change the adolescents become able to use logic thinking, to think abstractly; and convert thinking from direct concrete to abstract thinking imagine things , those changes will motivate adolescents to love and search in spirituality. Adolescents feel with satisfaction when they do health risk behaviors like substance use despite the negative consequences of use because they think through their emotions and difficult to understand the relationship between cause and effect of substances. Psychosocial development phase: adolescents like to act as adults during the early adolescent period between 12 and 14 years of age. Adolescents like to do adult roles being independent and ignore advice from parents, being neat and in a good appearance in front of others \[7\] \[10\]. Additionally, adolescents do permanent relationship during the last stage of adolescent 18 - 21 years of age \[7\] \[11\]. Therefore, adolescents are confused about which act fit their identity, so they are at risk to do maladaptive behaviors like substance use disorder. Psychological development phase: Brain development has an integral part in developing SUD, areas in the brain which are responsible for decision making and behavioral impulses which myelinated late stimulate impulsiveness in adolescents which can result in health risk behaviors like substance use disorder \[13\]. The search process targeted articles published in peer-reviewed journal that is relevant to identified study key words. Boolean operators AND, OR have been applied separately and in combination with the keywords to expand, combine, or exclude keywords in a search to narrow down the results. The reviewed studies focused on the risk factors and associated factors of substance use disorder among adolescents internationally, which used quantitative and qualitative approaches in order to understand deeply which factors stimulate adolescents to consume illegal drugs. The relevant articles in this integrative review were limited to: written in English language, published in peer-reviewed nursing and non-nursing journals, the period of publication from onward, Abstracts, conference papers, unpublished reports, opinion papers were excluded to be included from this review. The primary search in selected databases retrieved articles, and articles through other resources. After removing duplicates unique articles were identified. After screening the abstracts, articles were excluded because they did not meet the inclusion criteria. From the reviewed abstracts, 48 articles met our search criteria and were reviewed in full. Of these, 9 final articles were selected. Afterward, the selected articles were assessed for eligibility based on their full-text Figure 1. Nine relevant articles have been reviewed and the following data have been extracted: study purpose, design, sample, and findings. The authors compared the articles; findings interpreted to extract themes and grouped them based on their similarities. On the whole, all of the nine articles published between and are reviewed three qualitative studies, four cross-sectional quantitative studies, and two correlation quantitative studies ; all articles presented in Appendix. In order to address the purpose of this integrative review, the findings the risk factors of substance use disorder were categorized into common themes, a. Figure 1. Search strategy outcomes. The following four main themes were emerged: 1 influence of psychological factors on adolescents 2 influence of socio-cultural factors on adolescents 3 influence of biological factors on adolescents and 4 influence of environmental factors on adolescents. The reason for emerging these themes identifies factors that influence adolescents to have SUD. Child neglect and the onset of substance use disorders among child welfare. This study involved adolescents to clarify the relationship between child abuse and substance dependence versus child neglect and substance dependence. Data set used by the researchers was from The National Survey of Child and Adolescent Well Being II \[15\] , it is a longitudinal data set which represents children and young people aged 0 - 18 from 83 counties in New York. The data set contains much information about the social relationship, services needs, mental health and academic achievement for children and their caregivers and other important information. The results of the study showed that maltreatment of a child and youth increases the risk of SUD, child and youth negligence considered one of the most common maltreatment types which increase the likelihood to emerging of SUD. Other types of child maltreatment like psychological aggression, physical assault, and sexual abuse can lead to SUD in the presence of negligence. Child and youth negligence is the lack of supervision and monitoring by parents or caregivers \[14\]. Youth delinquency and health risk behaviors can be the result of child negligence \[14\]. Many adolescents may go to take illegal drugs in order to forget painful memories, self-blame, and depression \[14\]. Moreover, a cross-sectional quantitative study conducted by Ali, Dean Jr. Data set taken from the national survey on drug use and health NSDUH \[16\] , this data collected annually using face to face interviews from parents and their children for the purpose of detecting the prevalence and correlates of substance use disorders among civilians in the United States ages 12 years and above. The data collected from 67, participants who are completed the interview. The parent-child data collected over six years from to to examine the relationship between adolescent with SUD and parent with any mental disease or SUD separately from mothers and fathers. The multivariate regression analysis has conducted that show the parents with any mental illness and SUD influence their adolescents to have SUD, but mothers have more influence than fathers. A cross-sectional study conducted in the correctional institute in Jimma by Yitayih et al. The participants were The findings of this study showed that the prevalence of SUD was Additionally, the study reported that people who lack social support are more likely to have SUD, the people live in urban areas are more likely to have SUD than people live in rural areas, the people with psychopathy are more likely to have SUD than people without psychopathy, and lastly people who lack supervision are more likely to have SUD. An exploratory quantitative correlational study utilizing longitudinal analysis method conducted by Yoon et al. In this study, the sample size was a secondary data analysis with of adolescents at risk to develop substance use which drawn from the longitudinal studies of child abuse and neglect LONGSCAN. This sample size was enough to eliminate the sampling error and being representative of the target population. The study aimed to examine the type of maltreatment in early childhood within 0 - 5 years, in mid-late childhood within 6 - 12 years, and its effect on early substance use among adolescents with a high risk of maltreatment, and examine the role of father involvement during childhood. The data was collected during ages 4, 6, 8, 12, 14, 16 and 18 in the period from July to January , using Interviews from different age group, but in this study, the data used was data collected on ages 12 and The data was restricted to include only the adolescents who have a father because the aim of the study is to examine the role of father involvement in decreasing the likelihood of adolescents to be a substance user. The results discussed that white adolescents are at high risk to have substance use two times than black adolescents. The mothers with high education degree are less likely to have adolescents with substances use, while mothers without high education degree or illiterate are more likely to have adolescents with substance use. Furthermore, this study did not assess many maltreatment characteristics like severity, frequency and age onset of maltreatment. Therefore, the study cannot be generalized to all population because some confounding variables cannot be controlled. One of these variables was a participant who has a family with SUD. A qualitative retrospective content analysis conducted by Davis, J et al. The study sample was 20, adolescents who entered a project for substance use treatment. The authors used latent class and multi-class analysis to discover if the adolescent victimization is a risk factor for substance use disorder. The data was taken from the Chestnut Health System in the United States who used the GAIN-1 Global Appraisal of the individual needs coordinating center assessment tool which consisted from a structured interview with more than one hundred scales. The data were collected by the treatment agency staff from to after they received a special training by specialties for being certified to conduct the interviews. The participants recruited by different sources: Juvenile justice system, school referral, parents and self-referral. The results of the analysis using latent class analysis LCA in Mplus version 8 were reported that nearly a third of the sample exposed to victimization many times and for a long duration of time and the assaulter was a family member or a trusted one. Moreover, the victimization has different types like physical abuse, sexual abuse, and negative social reaction, perceived life threat, witnessing violence, emotional abuse, and trusted perpetrator. The study results showed that adolescents who experienced poly victimization and high harmful trauma such as; emotional, physical and sexual abuse and abused by family member or a trusted one are the riskier to have substance use disorder compared to low all class. The study used a large sample size which considered a strength point, the analytical process takes into consideration multiple aspects of victimization, the study cannot be generalized because it conducted in one country in the United States, the study just interested with characteristics of victimization and did not report other types of trauma such as; natural disasters, wars, car accidents, and domestic violence and also the research authors did not detect the frequency of associated trauma characteristics. A qualitative study was conducted by Berlowitz et al. The data was collected through semi-structured interviews with 13 practicing experts. The experts reported that Stressful life events such as; sexual abuse, childhood abuse, and disappointment in a job or a relationship were considered the factors that contribute to SUD. Additionally, the lack of love, caring from family or parents can play an integral role to cause adolescents having SUD. The personal tendencies such as curiosity, low self-esteem, experimentation, and being weak were influenced the adolescent to be a substance user. The emotional changes or mood fluctuations like anger, anxiety, grief, feeling with loneliness, and lack of attachment with family was also influenced adolescents to be a substance user. A cross-sectional study conducted by Iranpour et al. The aim of this study was to develop risk and protective factors of substance use scale to determine risk and protective factors influencing substance use among adolescents. The study participants were male students from 9 th and 10 th grade 14 - 18 years old at public high schools in Kerman, Iran were selected through multistage cluster sampling. The study results reported that both smoking and alcohol are considered a gateway for SUD. Also, there are many factors that increase the tendency to consume illicit drugs and these factors includes wrong beliefs and perception about the effects of illicit substances, and they think that hookah and alcohol do not have negative consequences like other illicit substances, lack of bonding and attachments with parents and lack of family monitoring increase the tendency of adolescents to have SUD, inappropriate relationship between family and adolescents increase the tendency of adolescents to have SUD. A cross-sectional study conducted by Mason et al. The aim of this study aimed to examine the relationship between early age alcohol use and the risk of adolescent alcohol problems. The sample selection was from Victoria 54 classes in 54 schools. Washington 51 classes in 51 schools. The study results reported that poor self-regulation and peer aberration increase the tendency of adolescents for alcohol abuse. Moreover, this is consistent with other studies that alcohol use considered a gate way for substance use disorder \[21\]. This study used self reported questionnaire to collect data which mean that may be there is a risk for bias. The sample was from to states in the USA which mean that it is not representative and cannot be generalized to all states. Substance use disorder criteria in DSM-5 \[5\] \[22\] includes the following: Consuming large amounts of substances more than expected or planned, failed to stop taking substances, Long period of time dispended on consuming substances, Consuming substances lead to inability to fill the ideal roles work, school or home , Intense desire for the substance, Continuous taking the substances despite it is consequences on health and mental functioning, Continue to take the substance despite its negative effects on the relationship loss of friendship, loss of partner , Use the substance during dangerous situations such as driving or duty at work, Disregard to participate in enjoying activities due to substance use, Take more amounts of substances over time to get the same preceded desired effect and finally withdrawal symptoms occur if the substance user stops taking substances. These withdrawal symptoms like nausea, irritability, fatigue, vomiting, hand tremors and seizure. The purpose of this study was to deeply understand factors that influence morocco adolescents to consume illegal substances through exploring the perceptions of students, their parents, and teachers. The study participants were 8 groups of adolescents 28 boys and 28 girls with age from 14 - 16 years, 5 groups of parents 5 females and 21 males , and 4 groups of teachers 13 males and 5 females. The results of this study showed that there are six emerging themes in which considered the factors that influence adolescents to consume substances; the first one was the perceived benefits from the substance use; adolescents believe that they can feel with pleasure and forget painful emotions through consuming substances. The second one was lack of awareness; which means they have a lack of knowledge about the side effects and complications of substance use. The third one was lack parental supervising; which mean that parents forget to monitor their children, they do not have time or they are busy all the time. The forth one was peer pressure and family influence; this means that if the family or some of the family members are abuse. The fifth one was psychological problems like personality disorders and another theme was low academic achievement and absenteeism; adolescents who absence from the school they are at high risk to make friendship with gangs. Moreover, this study conducted in two schools in urban areas in Morocco, which means that the results of the risk factors for substance use in adolescents cannot generalized in other countries. The aim of this literature review was to identify factors that influence adolescents to have substance use disorder internationally in which four themes emerged. The psychological factors showed increased the risk of having SUD. Therefore, the adolescents with previous stressful life events, painful trauma, painful memories of self-blame and depression at high risk to have SUD \[1\] \[14\]. The adolescents with mental illness like psychopath and personality disorder are at high risk to consume illicit substances and have SUD \[14\] \[23\]. The adolescents who experienced different types of abuse during childhood are at high risk to have SUD \[18\]. The socio-cultural factors such as; lack of monitoring by parents, lack of social support, sexual abuse, lack of bonding, and victimization by family increase the risk for adolescents to have SUD \[17\] \[18\]. The biological factors such as; personal tendencies curiosity and experimentation among adolescent increased the risk to have SUD \[1\]. The environmental factors such as; lack of knowledge, peer pressure, imitating family members, family with uneducated mother, low academic achievement and absenteeism increase the risk to have adolescents with SUD. The reviewed articles about the factors associated with SUD and their influences among adolescents have shown that there are different factors that influence adolescents to consume illegal substances. On the other hand, adolescents of educated mothers are less likely to have SUD because they educate their children about dangerous of illicit substances. Also, family support, strong attachment between children and parents, supervision by parents, pay attention and interest to children by their parents decrease the risk of adolescents to have SUD. At the same time, studies reported that adolescents are risker to have SUD because, in this developmental stage of adolescence, adolescents have personal tendencies like curiosity and experimentation to try any heath risk behaviors which is related to biological factors. Many of the revised articles questioned ways of adaptation and management for SUD in addition to the factors causes SUD, which means that less focusing on risk factors for SUD. The gaps were that some articles did not adequately highlight the process of occurring SUD by adolescents, did not adequately give clear examples how adolescents go to consume illegal substances after exposed to painful traumas or stress or any risk factors for SUD. Further studies are needed to address the role of the family in protecting adolescents from getting SUD and the other risk factors for SUD among adolescents as a specific age group. Less attention is given in the literature on the risk factors for SUD among adolescents. The authors state no conflicts of interest related to the publication of this paper. Revista Brasileira de Psiquiatria, 40, Routledge, London. Developmental Cognitive Neuroscience, 32, Medical Clinics of North America, , Child and Adolescent Psychiatric Clinics, 25, WW Norton, New York. Adolescent Psychiatry, 29, 3. Child Abuse Review, 25, Addictive Behaviors, 59, BMC Psychiatry, 18, Addiction and Health, 7, Psychology of Addictive Behaviors, 25, Substance Abuse Treatment, Prevention, and Policy, 13, Home Journals Article. Malek M. Khalil 1 , Ayman M. DOI: Share and Cite:. Khalil, M. Open Journal of Nursing , 9 , Introduction Substance Use Disorder SUD is one of the difficult problems and considered a global health problem that increases the burden on families and governments, more than billion dollars dispensed on substance use yearly in USA \[1\] \[2\]. Materials and Methods 2. Search Strategy The search process targeted articles published in peer-reviewed journal that is relevant to identified study key words. Inclusion Criteria The relevant articles in this integrative review were limited to: written in English language, published in peer-reviewed nursing and non-nursing journals, the period of publication from onward, Abstracts, conference papers, unpublished reports, opinion papers were excluded to be included from this review. Results Nine relevant articles have been reviewed and the following data have been extracted: study purpose, design, sample, and findings. In order to address the purpose of this integrative review, the findings the risk factors of substance use disorder were categorized into common themes, a Figure 1. Conflicts of Interest The authors state no conflicts of interest related to the publication of this paper. References \[ 1 \] Berlowitz, I. Journals Menu. Contact us. All Rights Reserved. Berlowitz, I. Higgins, K. World Health Organization Substance Abuse. Kapur, S. Sanders, M. Morris, S. Lisdahl, K. Chadi, N. Sharma, A. Erikson, E. Beckson, M. Lalayants, M. Dowd, K. Ali, M. Yitayih, Y. Yoon, S. Davis, J. Iranpour, A. Mason, W. El Kazdouh, H.

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