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Microdosing San Pedro (mescaline) | Microdosing Institute

Click here to learn how to Microdose! The San Pedro cactus Echinopsis pachanoi and Echinopsis peruvianus is a fast-growing cactus native to the Andes region in South America. Mescaline is a relatively safe substance that has extraordinary properties in high doses and can also be a wonderful substance for microdosing. Indigenous peoples in Mexico and South America have been using San Pedro and peyote for ceremonial and ritual purposes for over years. The Huichol tribe of Mexico, for example, believes that the cactus has healing properties. Europeans discovered peyote after Spain conquered Mexico in the early sixteenth century. Attempts to suppress its use, predominantly by missionaries, were unsuccessful. In fact, after being forced into reservations, peyote rituals spread further to Native Americans of the plains in the United States, such as the Osage Nation. Mescaline was isolated from peyote for the first time in by the German chemist Arthur Heffter. It played an essential role in the work of the American chemist Alexander Shulgin, who used it as a starting point for synthesizing several new psychedelic substances. Unfortunately, mescaline was never thoroughly researched for its potential therapeutic effects because in the s research abruptly shifted to LSD —a synthesized psychedelic with similar attributes but fewer side effects. Only medical and scientific research with mescaline in humans is allowed under the UN Convention, but research with psychedelics proves incredibly difficult in practice. Even though mescaline is illegal, the psychoactive plants which contain mescaline are legal or decriminalized in many countries including the Netherlands and the United Kingdom. Therefore, you can obtain these plants from plant shops and garden centers or specialized vendors of mescaline-containing cacti. San Pedro, however, is widely available and not at risk of extinction, which is why when it comes to microdosing with mescaline, we strongly recommend microdosing San Pedro over other mescaline containing cacti. Learn more about the ethical use of plant medicines here. Mescaline cacti are peeled and boiled into a juice or dried and then consumed. The taste can be very bitter, but one way to dispel the bitter taste is to drink pineapple juice or grapefruit juice while chewing. A high dose of mescaline is between milligrams to milligrams and from this type of cactus it induces a peaceful, colorful, warm, mystical state of being. San Pedro has a milder effect than peyote because peyote contains additional alkaloids. Mescaline is widely regarded as one of the most gentle, insightful, and euphoric psychedelics. It emphasizes bodily and tactile sensations more than psychedelic tryptamines such as psilocybin or DMT, which have a more intense headspace and dynamic visual geometry. Because of its mellow, organic, yet complex nature, people see high potential in the use of mescaline in psychedelic therapy. Mescaline, short for 3,4,5-Trimethoxyphenethylamine, is part of the phenethylamines class, which includes MDMA and several antidepressants. Like many other psychedelic substances, including LSD and psilocybin , it binds to the serotonin receptors in the brain. Researchers are still searching to explain how this leads to a psychedelic experience when consuming these substances. That means that at some point you need a higher dose to feel the same effect. However, adverse psychological reactions can happen to people predisposed to the following psychological or psychiatric disorders:. Some possible risks occur when combining several safe substances. The following list includes contraindicated combinations with mescaline, although this might not be exhaustive. We suggest avoiding combining substances when microdosing San Pedro. Currently, little is known about microdosing San Pedro; however, we have collected several anecdotal stories from community members and combined them with our own experience to come up with three important observations:. The single most important reason these cacti are not a popular trip drug by themselves is that mescaline can vary significantly from one cactus to another. This depends, among other things, on the species, the age, and the place of growth of the cactus, which makes accurate dosing a challenge. Therefore, we advise buying your San Pedro cactus from a specialist. Our partner shop, Microdose. Each cactus has a different mescaline content. An average microdose of dried San Pedro cactus is between 1. Mix everything you have left into a paste. This will ensure that the mescaline will be evenly distributed throughout your whole batch of San Pedro. Put the San Pedro in a boil and leave it to dry. To speed up the process, direct a fan onto the San Pedro paste. When everything is crispy dry, you can grind everything into a fine powder. This works best using an electric coffee grinder. To make microdosing San Pedro as effortless as possible, you could encapsulate the powder and prepare your microdoses ahead of time. NOTE: Remember to remove the weight of an empty capsule from the total weight. To find out which dose is your sweet spot, start with the lowest dose 1 capsule of 0. If you feel this microdose is too low, take a higher dose the next microdosing day 2 capsules for a total of 1. For more in-depth information, read our guide on how to microdose. NOTE: Keep in mind that this is a rough indication. The potency of each batch depends on the size of the cacti, their potency, and the amount of flesh you cut and use from the cactus. This means that each time you dry the cacti, you then have to find your sweet spot for this specific batch. A good rule of thumb is; the whiter flesh, the weaker the potency. After determining your sweet spot, you can get started with microdosing San Pedro. We advise microdosing once every three days following the Fadiman protocol. The process of drying, powdering, and encapsulating is not very difficult, but it takes a little dedication and patience. Processing psychedelics like San Pedro is not legal in the Netherlands and many other countries. If you want to start microdosing mescaline right away, an unregulated synthetic analog is currently available in most countries in the European Union. EN NL. Microdosing San Pedro mescaline. Table of Contents. History of the San Pedro cactus. Legality of the San Pedro cactus. Effects of San Pedro at high doses. Mental effects at high doses Change of perception—seeing things more colorful and intense. Things take on contours, distort or emit light. Distortion of time Distortion of space Synesthesia—mixing of sensory perceptions such as seeing music, hearing an image, or smelling colors Euphoria Mood sensitivity—one moment someone is feeling euphoria, the next to go into an anxious mood Profound insights Losing touch with reality Magical or religious experiences Physical effects at high doses Increased heart rate Increased blood pressure Slight acceleration of the breathing Excessive salivation Increased body temperature and sweating may alternate with chills and tremors Mescaline is widely regarded as one of the most gentle, insightful, and euphoric psychedelics. Pharmacology of mescaline. However, adverse psychological reactions can happen to people predisposed to the following psychological or psychiatric disorders: Anxiety Paranoia Delusion Psychosis Possible negative physical side effects include: Nausea Diarrhea Abdominal cramps Some possible risks occur when combining several safe substances. Microdosing San Pedro. Currently, little is known about microdosing San Pedro; however, we have collected several anecdotal stories from community members and combined them with our own experience to come up with three important observations: Microdosing San Pedro requires more preparation than microdosing magic truffles or microdosing magic mushrooms The amount of mescaline is frequently unknown, as it varies depending on the harvest and even cactus. If microdosing magic mushrooms makes you restless, microdosing San Pedro can be an excellent alternative The average dosages for microdosing dry San Pedro are: Low microdose: 1. Effects of microdosing San Pedro. Slow onset: it takes about 1. Risks of microdosing San Pedro. Ready to shop for San Pedro? Shipping within the European Union only. Shop now. How to prepare your dose for microdosing with San Pedro. Preparing the San Pedro cactus. Before starting to process the San Pedro cactus, remove the spikes with a pair of scissors to prevent any damage to your skin. The most effective way of doing this is to cut with an angle of 45 degrees on each side of the spikes and take them out with your hand. There are not that many, and the spikes are quite evenly distributed, so this is relatively easy Cut the San Pedro cactus in four even parts in the longitudinal direction. Then cut the inner parts out of the peel. Boiling the San Pedro cactus. Put milliliters of water in a pan and put it on the stove. Boil it for approximately 20 minutes until the flesh is soft. Remove the outer layer when everything is boiled soft. Scrap the cactus off from the peel with the knife. Mix the San Pedro. Dry the San Pedro. Grind the San Pedro. Encapsulate the powered San Pedro. Finding your sweet spot for microdosing San Pedro. Start microdosing San Pedro. Another option for microdosing mescaline. Your story is powerful Your experience can help orient other microdosers, and benefit the community at large. Consider taking a couple of minutes to write down your experiences with microdosing positive or negative. Share your story. Heffter, A. PLOS Medicine. About Microdosing What is microdosing? Benefits of Microdosing Dr. Facebook Youtube Instagram Linkedin. Subscribe to our newsletter:. Privacy policy.

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My experience of drinking San Pedro in the Sacred Valley was an incredibly powerful, humbling and beautiful experience. I would seriously recommend it to anyone inclined to such experiences. San Pedro is a species of psychedelic cactus native to the Andes — scientific name Echinopsis pachanoi. The cactus has a history of use in Andean traditional medicine going back thousands of years and is a part of the native culture. For this reason San Pedro is completely legal , and therefore openly and readily available. It is sold in powder form, after the cactus has been dried and ground. It was very cheap and excellent quality. Just go to the medicines aisle and ask around for San Pedro. You can buy in batches of 33g — one standard dose. If you are going to have a strong trip, typically you will start to feel effects before the two hour mark. Be sensible with your dosage! One you have the dust, all you need to do is mix it in water and then drink it. No special preparation or boiling needed. My advice would be to drink on an empty stomach. This will help with the absorption of the San Pedro into your body, and will also lessen nausea, a common side effect of the cactus. This is really up to you, but here are a few options as to where and in what manner you take San Pedro. Scroll down for more info on each one. This was the option I went for and in many ways the most straightforward. I wanted to be alone and in nature so it was perfect. Peru is abound with incredible nature so finding a place should be easy. Staying in Pisac, I just left town and went out into nature, through woods and by a river. If you are going alone, pay careful attention to where you are going and be prepared. When deciding where I would go I asked a friend who I was staying with for suggestions. He advised me an area of woods and told me to stay by the river. That was important advice as when heading back the woods were like a maze and appeared identical in all directions. Luckily, I was able to locate myself in relation to the river and follow it back towards town. Clothes suitable for heat and cold On my trip the temperature varied massively depending on the shadow of clouds — it was scorching under direct sunlight, then pretty damn chilly under the shadow of a large passing cloud. I changed clothes, switching between jeans and shorts, putting on and removing layers, a few times throughout the trip. Ideally find a spot in shade. Something to lie on \\\\\\\[e. I took a sleeping mat for my trip and certainly made use of it, lying on it for a good 6 hours. You can of course just lie on the ground but I think its nice to have something to lie on. Depending on where you are it may or may not be easy to find a comfortable spot. I highly value physical comfort during a psychedelic experience and think it can make a big difference to the experience itself. On my trip I took some snacks and ended up not eating anything. Anything else is optional and additional. What else you take depends entirely on you and what you would like with you. Here are some suggestions;. At times I found writing in it was like talking to a friend, giving me a sense of company. Marijuana — The nausea can be quite bad and weed can certainly help this. I smoked one joint as the nausea started to come on, about an hour after drinking, and felt immediately relieved. The nausea came back again a couple hours later — I smoked another small joint, and that was the end of the nausea for the entire trip! Another option would be to camp out in nature. There are plenty of guides and facilitators around the town of Pisac offering Wachuma hikes and different types of ceremony. There are all kinds of events — from hikes in nature to ceremonies with mantras and sacred songs. If you find shamanic or new age ceremonial type things to be a bit cringe or just not to your tastes, a hike would surely be preferable, or…. Another option is finding some others and organising your own ceremony. This is more easy than it sounds. The day after my own experience I was invited by an Argentinian to join a ceremony she was organising with her friends a few days later. Some others were also organising trips to Machu Picchu with a San Pedro stop en route. Needless to say you should feel comfortable with everyone who you plan on doing this with. However, if you do decide to you may well be in for an ineffably beautiful and potentially life-changing experience. I am still awed at what I experienced, and would absolutely drink again when the right opportunity arises. Safe travels! Peyote contains psychoactive alkaloids, and like the San Pedro cactus, the principal one is \\\\\\\[…\\\\\\\]. First Name. Feel ready and prepared before your journey. Cover bases of preparation at a glance. Walk through with friend or group beforehand. Head to Calle San Pedro. Head to Seccion Hierbas Medicinales. Three bagged doses — 33g in each. Related posts:. Explorer's Guide: Picking Peyote. Sign up to receive your.