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This year, we take on the Ionian Islands of Greece, exploring Corfu and the neighboring paradise islands in the Ionian. What more could you ask for? Check in in the afternoon and get settled into your rooms before taking a look around your new home for the next 8 days. If everyone arrives early enough, we will set sail for Kassiopi! Settle in and freshen up before we meet up as a group for our welcome dinner and drinks. Sit back and watch the sun go down with beers in hands and get to know your new travel buddies. Welcome to paradise. We set sail to Syvota, a smaller Ionian island renowned for being one of the most beautiful in Greece. We dock up around midday and have a little boat party! We spend the day partying under the glistening sun, kicking back with a cocktail in hand or diving into the sea until you nail that backflip. This is the summer of dreams, baby! In the evening we head out to explore and dance the night away. Oi oi land ahoy! Although Parga is still part of the mainland, the scenery is that of an island, stunning backdrops, beautiful beaches. We spend the day exploring the town. Explore at your own pace. In the evening we get ready onboard before we head out for dinner and hit up Parga Town for a few drinks! Spend the day exploring the tow. Atop the hill overlooking Parga town lies the ruins of an old Venetian Castle built in the 11th century. Plus the views are out of this world. The late afternoon is free to do as you please. Gaios port is like a painting come to life. Sit back and watch as we sail into its stunning backdrops. In the day we can either stop at Kipiadi bay or Panagia Island for a swim, both destinations are hidden gems of the Ionian Sea, and you may not see anyone else there! With fewer tourists, the waters are crystal clear, the sand is golden and deserted. We spend the day swimming in warm blue waters before heading back to Gaios port where we dock up for the night. The port is lively, fun and has some of the best cocktails around! Today we take a short sail across to Antipaxos for some swim stops. Vrika beach is one of the best for snorkeling, with a small cave to the right. Freshen up in the evening as we watch the golden sunset onboard with a beer in hand. How do you wind down a perfect day? Dinner with the captain of course! Nurse your hangover laying out on the deck, grab that last morning of tanning and let the crisp sea air re-energize you after a night of sipping one too many cocktails. After taking some snaps of these epic views we head back onboard and get ready for one last night together! Dance all night, and after one too many drinks, inevitably get all emotional and tell each other just how much you love them. Today is check out day. But all good things must come to an end. Name required. Email required. Tell Me About Yourself!!! Sign Me Up!! Share this: Twitter Facebook. Like this: Like Loading Loading Comments Email Required Name Required Website.
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También tenemos algunas babitas en stock 1x$ 2x$ Photo by Elisabet Parga in Pigüé. Después de mucho volvimos y tenemos este toallón con una babita.
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Cocaine has been used for thousands of years for its recognized medicinal properties and for its personally gratifying qualities. The first archeological finding of human use of coca leaves dates back to b. The leaves were chewed by chasquis on-foot mail carriers of the Incan empire to decrease fatigue and enhance endurance as they delivered royal messages by running from town to town. This is a preview of subscription content, log in via an institution to check access. Institutional subscriptions. Kleber HD. Cocaine abuse: historical, epidemiological, and psychological perspectives. J Clin Psychiatry. PubMed Google Scholar. Cocaine: history, social implications, and toxicity: a review. Semin Diagn Pathol. Article PubMed Google Scholar. Position statement: medical use of cocaine Medicinal use of cocaine: a shifting paradigm over 25 years. Current practices of cocaine administration by UK otorhinolaryngologists. J Laryngol Otol. DDS No. ADM 94— Google Scholar. MacDonald D. From the alcohol, drug abuse, and mental health administration. Drug abuse warning network medical examiner Annual Dataaa Series D1. SMA ADM National household survey on drug abuse. European Drug Report: Trends and developments. Prevalence and demographic correlates of symptoms of last year dependence on alcohol, nicotine, marijuana and cocaine in the U. Drug Alcohol Depend. Drug abuse warning network, national estimates of drug-related emergency department visits. HHS Publication No. Emergency health consequences of cocaine use in Europe. United Nations Office on Drugs and Crime. Hollander JE. The management of cocaine-associated myocardial ischemia. N Engl J Med. The cardiovascular effects of cocaine. Ann Emerg Med. Smoked cocaine: patterns of use and pulmonary consequences. J Psychoactive Drugs. Intraurethral cocaine administration. Cocaine plasma concentration: relation to physiological and subjective effects in humans. Kinetics of cocaine in humans after intravenous and intranasal administration. Biopharm Drug Dispos. Cocaine metabolism in man: identification of four previously unreported cocaine metabolites in human urine. J Anal Toxicol. Cocaine metabolism: cocaine and norcocaine hydrolysis by liver and serum esterases. Clin Pharmacol Ther. Biological effects of cocaine derivatives I: improved synthesis and pharmacological evaluation of norcocaine. J Pharm Sci. Effect of cocaine and cocaine metabolites on cerebral arteries in vitro. Life Sci. Effects of cocaine, benzoylecgonine, and cocaine metabolites in cannulated pressurized fetal sheep cerebral arteries. J Appl Physiol CAS Google Scholar. Decreased plasma cholinesterase activity enhances cocaine toxicity in mice. J Pharmacol Exp Ther. Association between life-threatening cocaine toxicity and plasma cholinesterase activity. Hemodynamic and cerebral blood flow effects of cocaine, cocaethylene and benzoylecgonine in conscious and anesthetized fetal lambs. Ambre J. The urinary excretion of cocaine and metabolites in humans: a kinetic analysis of published data. Protracted elimination of cocaine metabolites in long-term high-dose cocaine abusers. Am J Med. Jatlow PI. Drug of abuse profile: cocaine. Clin Chem. Inaba T. Cocaine: pharmacokinetics and biotransformation in man. Can J Physiol Pharmacol. Dinis-Oliveira RJ. Metabolomics of cocaine: implications in toxicity. Toxicol Mech Methods. Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine. Cocaethylene: pharmacology, physiology and behavioral effects in humans. Comparison of the effects of cocaine and its metabolites on cardiovascular function in anesthetized rats. J Cardiovasc Pharmacol. Concurrent use of cocaine and alcohol is more potent and potentially more toxic than use of either alone—a multiple-dose study. Biol Psychiatry. Cocaethylene causes dose-dependent reductions in cardiac function in anesthetized dogs. Elsworth JD. Cocaethylene is a pharmacologically active metabolite of cocaine formed after combined intake of cocaine and ethanol. Soc Neurosci Abstr. Cocaethylene, a metabolite of cocaine and ethanol, is a potent blocker of cardiac sodium channels. World Drug Report United Nations publication, Sales No. Correlation between cocaine prices and purity with trends in emergency department visits in a major metropolitan area. J Urban Health. The relationship of quality and price of the psychostimulants cocaine and amphetamine with health care outcomes. Adulterants in illicit drugs: a review of empirical evidence. Drug Test Anal. Agranulocytosis associated with cocaine use — four States, March November An analysis of cocaine powder in the Netherlands: content and health hazards due to adulterants. Levamisole-adulterated cocaine: what about in European countries? Analysis of cocaine and its adulterants in drugs for international trafficking seized by the Brazilian Federal Police. Forensic Sci Int. Levamisole exposure and hematologic indices in cocaine users. Acad Emerg Med. Levamisole tainted cocaine: an emerging health issue. Levamisole: a dangerous new cocaine adulterant. Levamisole-induced occlusive necrotizing vasculitis of the ears after use of cocaine contaminated with levamisole. J Med Toxicol. Larocque A, Hoffman RS. Levamisole in cocaine: unexpected news from an old acquaintance. Clin Toxicol. Billman GE. Mechanisms responsible for the cardiotoxic effects of cocaine. Cocaine-induced wide complex dysrhythmia. J Emerg Med. The effects of acute and chronic cocaine use on the heart. Wang RY. Am J Emerg Med. Cocaine increases extraneuronal levels of aspartate and glutamate in the nucleus accumbens. Brain Res. Cocaine: cardiovascular effects in relation to inhibition of peripheral neuronal monoamine uptake and central stimulation of the sympathoadrenal system. Arch Gen Psychiatry. Localization of dopamine receptor subtypes occupied by intra-accumbens antagonists that reverse cocaine-induced locomotion. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. J Psychopharmacol. Spivey WH, Euerle B. Neurologic complications of cocaine abuse. Pap A, Bradberry CW. Excitatory amino acid antagonists attenuate the effects of cocaine on extracellular dopamine in the nucleus accumbens. Glutamate receptor antagonists block cocaine-induced convulsions and death. Brain Res Bull. Platelet responsiveness and biosynthesis of thromboxane and prostacyclin in response to in vitro cocaine treatment. Effects of cocaine on human platelet aggregation in vitro. J Toxicol Clin Toxicol. Effects of cocaine on human platelets in healthy subjects. Am J Cardiol. Intravenous cocaine induces platelet activation in the conscious dog. Influence of intranasal cocaine on plasma constituents associated with endogenous thrombosis and thrombolysis. Cocaine-induced erythrocytosis and increase in von Willebrand factor: evidence for drug-related blood doping and prothrombotic effects. Arch Intern Med. Cocaine increases the endothelial release of immunoreactive endothelin and its concentrations in human plasma and urine: reversal by coincubation with sigma-receptor antagonists. Hematological indices of erythropoietin administration in athletes. Int J Sports Med. Effects of coca chewing on hormonal and metabolic responses during prolonged submaximal exercise. Erythrocyte reinfusion and maximal aerobic power. An examination of modifying factors. Unsuspected deep venous thrombophlebitis detected by gallium imaging. Clin Nucl Med. Cocaine-induced thrombosis of common iliac and popliteal arteries. Ann Vasc Surg. Intestinal ischemia caused by cocaine ingestion: report of two cases. Intestinal ischemia induced by cocaine abuse. Arch Surg. Wohlman RA. Renal artery thrombosis and embolization associated with intravenous cocaine injection. South Med J. Cocaine-related medical problems: consecutive series of patients. Coronary artery spasm, cardiac arrest, transient electrocardiographic Q waves and stunned myocardium in cocaine-associated acute myocardial infarction. A comparative study of the cerebrovascular complications of cocaine: alkaloidal versus hydrochloride—a review. Cocaine-induced myocardial infarction: an analysis and review of the literature. Vasospasm and thrombus formation as possible mechanisms of stroke related to alkaloidal cocaine. Sharff JA. Renal infarction associated with intravenous cocaine use. Cocaine-induced central retinal artery occlusion. Cocaine-induced psychosis and sudden death in recreational cocaine users. J Forensic Sci. Ambient temperature and mortality from unintentional cocaine overdose. Dopamine receptors in the central thermoregulatory pathways of the rat. J Physiol. Rhabdomyolysis and hyperthermia after cocaine abuse: a variant of the neuroleptic malignant syndrome? Acta Neurol Scand. Acute rhabdomyolysis associated with cocaine intoxication. Acute cocaine intoxication in the conscious dog: studies on the mechanism of lethality. Brust JC. Vasculitis owing to substance abuse. Neurol Clin. Stroke associated with cocaine abuse—? N Y State J Med. Neurovascular complications of cocaine. Epileptogenic properties of cocaine in humans. The neurovascular complications of cocaine. Surg Neurol. Cocaine induced intracerebral hemorrhage: analysis of predisposing factors and mechanisms causing hemorrhagic strokes. Hum Pathol. Migrainelike headache and cocaine use. Neurovascular complications of cocaine abuse. J Neuropsychiatry Clin Neurosci. Acute neurologic and psychiatric complications associated with cocaine abuse. Cocaine-induced aneurysmal rupture: an emergent negative factor in the natural history of intracranial aneurysms? Intracerebral hemorrhage in cocaine users. Cocaine abuse: neurovascular complications. Seizures in hospitalized cocaine users. The effect of haloperidol in cocaine and amphetamine intoxication. Cocaine-induced seizures. Earnest MP. Relation of cocaine use to seizures and epilepsy. Cocaine-related symptoms in patients presenting to an urban emergency department. Anxiety and substance use disorders: co-occurrence and clinical issues. Curr Psychiatry Rep. Prevalence and risk factors of psychotic symptoms in cocaine-dependent patients. Actas Esp Psiquiatr. Cocaine use and risk of stroke: a systematic review. In-hospital outcomes of aneurysmal subarachnoid hemorrhage associated with cocaine use in the USA. J Clin Neurosci. The incidence of acute cocaine or methamphetamine intoxication in deaths due to ruptured cerebral berry aneurysms. Intracranial hemorrhage associated with cocaine abuse: a prospective autopsy study. Cocaine-induced cerebral vasoconstriction detected in humans with magnetic resonance angiography. Impact of acute cocaine use on aneurysmal subarachnoid hemorrhage. A systematic review of evidence on the association between cocaine use and seizures. Seizures induced by the cocaine metabolite benzoylecgonine in rats. Cerebral atrophy in habitual cocaine abusers: a planimetric CT study. Myocardial ischemia and infarction related to recreational cocaine use. West J Med. Prospective multicenter evaluation of cocaine-associated chest pain. Acute myocardial infarction and chest pain syndromes after cocaine use. Cocaine and chest pain: clinical features and outcome of patients hospitalized to rule out myocardial infarction. Ann Intern Med. An evaluation of cocaine-induced chest pain. Acute cardiac ischemia in patients with cocaine-associated complaints: results of a multicenter trial. Cocaine-associated myocardial infarction. Mortality and complications. Myocardial ischemia during cocaine withdrawal. Del Aguila C, Rosman H. Myocardial infarction during cocaine withdrawal. Chronic type A aortic dissection: an unusual complication of cocaine inhalation. Ann Thorac Surg. Rupture of the ascending aorta during cocaine intoxication. Intermittent cocaine use associated with recurrent dissection of the thoracic and abdominal aorta. Acute aortic dissection associated with cocaine abuse. Clin Cardiol. Transesophageal echocardiographic diagnosis of acute aortic dissection complicating cocaine abuse. Am Heart J. Analysis of cocaine-positive fatalities. Dissection of the aorta and coronary arteries associated with acute cocaine intoxication. Arch Pathol Lab Med. Cocaine-induced coronary-artery dissection. Effect of cocaine on coronary artery dimensions in atherosclerotic coronary artery disease: enhanced vasoconstriction at sites of significant stenoses. J Am Coll Cardiol. Potentiation of cocaine-induced coronary vasoconstriction by beta-adrenergic blockade. Cocaine-induced coronary-artery vasoconstriction. Frequency of coronary artery disease and left ventricle dysfunction in cocaine users. Acute myocardial infarction temporally related to cocaine use. Clinical, angiographic, and pathophysiologic observations. Quantitative analysis of amounts of coronary arterial narrowing in cocaine addicts. An angiographic and histologic study of cocaine-induced chest pain. Cocaine-associated chest pain. Arteriosclerotic toxicity of cocaine. Cocaine: an independent risk factor for aortic sudanophilia. A preliminary report. Presence and extent of coronary artery disease by cardiac computed tomography and risk for acute coronary syndrome in cocaine users among patients with chest pain. Effect of cocaine use on coronary calcium among black adults in Baltimore, Maryland. Reversible cardiomyopathy associated with cocaine intoxication. Dilated cardiomyopathy and cocaine abuse. Report of two cases. Effects of the intracoronary infusion of cocaine on left ventricular systolic and diastolic function in humans. Molecular characteristics of cocaine-induced cardiomyopathy in rats. Eur J Pharmacol. The pathology and etiology of cocaine-induced heart disease. Cardiovascular effects of cocaine: an autopsy study of 40 patients. Cocaine-induced torsades de pointes in a patient with the idiopathic long QT syndrome. Clinical safety of lidocaine in patients with cocaine-associated myocardial infarction. Monticciolo R, Sirop P. Atrial fibrillation after the use of intranasal cocaine. Hosp Physician. Electrocardiographic and hemodynamic effects of intravenous cocaine in awake and anesthetized dogs. J Electrocardiol. Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias. Fatal case of delayed repolarization due to cocaine abuse and global ischemia. Rev Cardiovasc Med. Cocaine-induced channelopathies: emerging evidence on the multiple mechanisms of sudden death. J Cardiovasc Pharmacol Ther. Cocaine-induced torsades de pointes in idiopathic long Q-T syndrome. Am J Ther. Management of cocaine-induced cardiac arrhythmias due to cardiac ion channel dysfunction. Cocaine-related aortic dissection: lessons from the International Registry of Acute Aortic Dissection. Pulmonary status of habitual cocaine smokers. Am Rev Respir Dis. Pulmonary histopathology in cocaine abusers. Diffuse alveolar hemorrhage temporally related to cocaine smoking. Delaney K, Hoffman RS. Pulmonary infarction associated with crack cocaine use in a previously healthy year-old woman. J Rheumatol. Rubin RB, Neugarten J. Cocaine-associated asthma. Airway complications from free-basing cocaine. Pulmonary artery medial hypertrophy in cocaine users without foreign particle microembolization. Crack lung: pulmonary disease caused by cocaine abuse. Crack abuse and asthma: a fatal combination. Thadani PV. Clinical manifestations and pathophysiology. Allred RJ, Ewer S. Spontaneous pneumomediastinum after cocaine inhalation. Spontaneous pneumomediastinum as a consequence of cocaine use. Birrer RB, Calderon J. Pneumomediastinum induced by inhalation of alkaloidal cocaine. Spontaneous pneumomediastinum: clinical and natural history. Pneumomediastinum and pneumothorax after inhaling alkaloidal cocaine. Torre M, Barberis M. Spontaneous pneumothorax in cocaine sniffers. Does detoxification reverse the acute lung injury of crack smokers? Nucl Med Commun. Subtype specific regulation of human vascular alpha 1 -adrenergic receptors by vessel bed and age. Ann R Coll Surg Engl. Ischaemic colitis induced by cocaine abuse. Br J Surg. Bowel ischemia and perforation after cocaine use. Am Surg. Acute gastroduodenal perforations associated with use of crack. Ann Surg. Crack-related perforated gastropyloric ulcer. J Clin Gastroenterol. Splenic infarction after cocaine use. Assessment of splanchnic blood flow in alcohol and drug abuse using radionuclide angiography. J Subst Abuse. Cocaine administration induces human splenic constriction and altered hematologic parameters. Lam M, Ballou SP. Reversible scleroderma renal crisis after cocaine use. Cocaine-induced scleroderma and scleroderma renal crisis. Schoenlein-Henoch purpura with necrotizing vasculitis after cocaine snorting. Clin Nephrol. Am J Med Sci. Cocaine intoxication presenting as preeclampsia and eclampsia. Obstet Gynecol. Acute interstitial nephritis induced by crack cocaine binge. Nephrol Dial Transplant. Antiglomerular basement membrane antibody-mediated glomerulonephritis after intranasal cocaine use. Cocaine-associated acute myoglobinuric renal failure. Cocaine-induced rhabdomyolysis masquerading as myocardial ischemia. Incidence of cocaine-associated rhabdomyolysis. Predicting the severity of cocaine-associated rhabdomyolysis. Hemodynamic effects of intravenous cocaine on the pregnant ewe and fetus. Am J Obstet Gynecol. Effect of cocaine on uterine blood flow and fetal oxygenation. Abruptio placentae associated with cocaine use. Temporal patterns of cocaine use in pregnancy. Perinatal outcome. Cocaine use in pregnancy. Dose—response effect of fetal cocaine exposure on newborn neurologic function. Level of in utero cocaine exposure and neonatal ultrasound findings. Cocaine use in women from a defined population: prevalence at delivery and effects on growth in infants. Cocaine: its effects on maternal and child health. Effects of maternal marijuana and cocaine use on fetal growth. Maternal and neonatal effects of moderate cocaine use during pregnancy. Neurotoxicol Teratol. Prenatal drug use in Minneapolis-St Paul, Minn. A 4-year trend. Arch Fam Med. Cocaine and its major metabolites in plasma and urine samples from patients in an urban emergency medicine setting. Urine testing for cocaine abuse: metabolic and excretion patterns following different routes of administration and methods for detection of false-negative results. Urine drug screening: practical guide for clinicians. Mayo Clin Proc. American College of Medical T. Interpretation of urine analysis for cocaine metabolites. Article Google Scholar. Clinical interpretation of urine cocaine and metabolites in emergency department patients. Ann Pharmacother. Heat stroke. Myocardial perfusion imaging with technetium m sestamibi in patients with cocaine-associated chest pain. Frequency and type of electrocardiographic abnormalities in cocaine abusers electrocardiogram in cocaine abuse. Cardiac troponin I and T concentrations in patients with cocaine-associated chest pain. Ann Clin Biochem. Utility of troponin I in patients with cocaine-associated chest pain. Impact of an abbreviated cardiac enzyme protocol to aid rapid discharge of patients with cocaine-associated chest pain in the clinical decision unit. West J Emerg Med. Effect of recent cocaine use on the specificity of cardiac markers for diagnosis of acute myocardial infarction. Validation of a brief observation period for patients with cocaine-associated chest pain. Cocaine-using patients with a normal or nondiagnostic electrocardiogram: single-photon emission computed tomography myocardial perfusion imaging and outcome. Coronary angiographic findings in patients with cocaine-associated chest pain. Characteristics, management, and outcomes of cocaine-positive patients with acute coronary syndrome from the National Cardiovascular Data Registry. Cocaine-associated chest pain in a chest pain center. The limited utility of routine cardiac stress testing in emergency department chest pain patients younger than 40 years. Stress testing in young low-risk patients with potential acute coronary syndromes. Stress testing in patients with cocaine-associated chest pain. Relationship between cocaine use and coronary artery disease in patients with symptoms consistent with an acute coronary syndrome. Assessment of myocardial infarction by CT angiography and cardiovascular MRI in patients with cocaine-associated chest pain: a pilot study. Br J Radiol. Atherosclerotic plaque burden in cocaine users with acute chest pain: analysis by coronary computed tomography angiography. Cocaine-associated chest pain: one-year follow-up. Factors associated with positive D-dimer results in patients evaluated for pulmonary embolism. Treatment of cocaine cardiovascular toxicity: a systematic review. Ice water submersion for rapid cooling in severe drug-induced hyperthermia. Otten EJ. Cooling it after drug induced hyperthermia. Lethal effects of cocaine are reduced by the dopamine-1 receptor antagonist SCH but not by haloperidol. Comparison of labetalol, diazepam, and haloperidol for the treatment of cocaine toxicity in a swine model. Ketamine use for acute agitation in the emergency department. The Journal of Emergency Medicine. The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance. Am J Drug Alcohol Abuse. Discriminative stimulus, subject-rated and cardiovascular effects of cocaine alone and in combination with aripiprazole in humans. A retrospective review of the use and safety of droperidol in a large, high-risk, inner-city emergency department patient population. The circulatory abnormalities of heat stroke. Dantrolene sodium for treatment of heatstroke victims: lack of efficacy in a canine model. Ineffectiveness of dantrolene sodium in the treatment of heatstroke. Crit Care Med. Fox AW. More on rhabdomyolysis associated with cocaine intoxication. Diazepam in the prevention of seizures and death in cocaine-intoxicated rats. Antagonism of intravenous cocaine lethality in nonhuman primates. Randomized, double-blind, placebo-controlled trial of diazepam, nitroglycerin, or both for treatment of patients with potential cocaine-associated acute coronary syndromes. Status epilepticus. A prospective, randomized, controlled trial of benzodiazepines and nitroglycerine or nitroglycerine alone in the treatment of cocaine-associated acute coronary syndromes. Alleviation of cocaine-induced coronary vasoconstriction by nitroglycerin. Nitroglycerin in the treatment of cocaine associated chest pain—clinical safety and efficacy. Influence of labetalol on cocaine-induced coronary vasoconstriction in humans. Experience with esmolol for the treatment of cocaine-associated cardiovascular complications. Death temporally related to the use of a Beta adrenergic receptor antagonist in cocaine associated myocardial infarction. Beta-blockers are associated with reduced risk of myocardial infarction after cocaine use. Beta-blockers for chest pain associated with recent cocaine use. Safety of beta-blockers in the acute management of cocaine-associated chest pain. Management of cocaine-associated chest pain and myocardial infarction: a scientific statement from the American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology. Use of phentolamine for cocaine-induced myocardial ischemia. Cocaine-induced ventricular fibrillation: protection afforded by the calcium antagonist verapamil. Effect of calcium channel antagonists on cocaine-induced malignant arrhythmias: protection against ventricular fibrillation. Potentiation of cocaine toxicity with calcium channel blockers. Cocaine toxicity and the calcium channel blockers nifedipine and nimodipine in rats. Nifedipine protects the heart from the acute deleterious effects of cocaine if administered before but not after cocaine. Calcium channel antagonists reduce the cocaine-induced decrease in cardiac output in a subset of rats. A calcium-channel blocker as antidote to the cardiac effects of cocaine intoxication. Alleviation of cocaine-induced coronary vasoconstriction with intravenous verapamil. Trouve R, Nahas GG. Antidotes to lethal cocaine toxicity in the rat. Arch Int Pharmacodyn Ther. Percutaneous interventions in patients with cocaine-associated myocardial infarction: a case series and review. Catheter Cardiovasc Interv. Clinical safety of thrombolytic therapy. Bush HS. A word of caution about thrombolytic therapy. LoVecchio F, Nelson L. Intraventricular bleeding after the use of thrombolytics in a cocaine user. Hemodynamic and electrophysiological actions of cocaine. Effects of sodium bicarbonate as an antidote in dogs. Reversal of the electrocardiographic effects of cocaine by lidocaine. Part 2. Concentration-effect relationships. Part 1. Comparison with sodium bicarbonate and quinidine. Lidocaine potentiation of cocaine toxicity. The effects of lidocaine pretreatment on cocaine neurotoxicity and lethality in mice. Usefulness of intravenous lipid emulsion for cardiac toxicity from cocaine overdose. Treatment of cocaine overdose with lipid emulsion. Cave G, Harvey MG. Should we consider the infusion of lipid emulsion in the resuscitation of poisoned patients? Crit Care London, England. Experimental treatments for cocaine toxicity: a difficult transition to the bedside. Intravenous tissue plasminogen activator in patients with cocaine-associated acute ischemic stroke. Download references. Ronald O. You can also search for this author in PubMed Google Scholar. Evidence obtained from well-designed cohort or case—control analytic studies, preferably from more than one center or research group. Evidence obtained from multiple time series with or without the intervention. Dramatic results in uncontrolled experiments such as the results of the introduction of penicillin treatment in the s could also be regarded as this type of evidence. Opinions of respected authorities, based on clinical experience, descriptive studies and case reports, or reports of expert committees. Reprints and permissions. Olmedo, R. In: Brent, J. Springer, Cham. Received : 08 August Accepted : 08 August Published : 23 September Publisher Name : Springer, Cham. Online ISBN : Policies and ethics. Skip to main content. Critical Care Toxicology. Abstract Cocaine has been used for thousands of years for its recognized medicinal properties and for its personally gratifying qualities. Access this chapter Log in via an institution. Farming Amphetamines: Khat Catha edulis Forsk. References Kleber HD. Google Scholar MacDonald D. Google Scholar Emergency health consequences of cocaine use in Europe. Google Scholar Hollander JE. View author publications. II-1 Evidence obtained from well-designed controlled trials without randomization. II-2 Evidence obtained from well-designed cohort or case—control analytic studies, preferably from more than one center or research group. II-3 Evidence obtained from multiple time series with or without the intervention. III Opinions of respected authorities, based on clinical experience, descriptive studies and case reports, or reports of expert committees. Rights and permissions Reprints and permissions. About this entry Cite this entry Olmedo, R. Publish with us Policies and ethics. Search Search by keyword or author Search. Navigation Find a journal Publish with us Track your research.
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