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The use of psychotropic substances among students: The prevalence, factor association, and abuse
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An increase in polydrug abuse is a major problem worldwide. A previous study showed that coadministration of methamphetamine and morphine induced lethality in rodents and humans. However, the underlying mechanisms by which the lethality is increased by the coadministration of methamphetamine and morphine have not been fully understood. Therefore, the present study was designed to determine the mechanism of increased lethality induced by methamphetamine and morphine. Furthermore, the lethal effect induced by methamphetamine and morphine was completely attenuated by immediate cooling after the coadministration of methamphetamine and morphine. It has been reported that methamphetamine-induced neurotoxicity can be blocked by lowering the temperature, and this effect might be mediated by a reduction of release of free radicals. These results suggest that activation of NMDA receptors and PARP play an important role in the increased lethality induced by methamphetamine and morphine. The Japanese Journal of Pharmacology. Already have an account? Sign in here. Journal of Pharmacological Sciences. Journal home All issues About the journal. Corresponding author. Keywords: methamphetamine , morphine , toxicity , oxidative stress. View 'Advance Publication' version October 6, Article overview. References Related articles 0. Figures 0. Content from these authors. Supplementary material 0. Result List. Previous article Next article. Related articles. Share this page. Register Already have an account?
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