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Given that the techniques used to test drug abuse liability are not free from criticism, a series of oral free-choice experimental procedures was adopted. Even if behavioural effects were evident and exhibited tolerance and dependence, no preference was shown. However, it was possible to select a group of etonitazene preferring rats. When etonitazene was offered in a free-choice only 1 day over 3, rats exhibited preference versus etonitazene even if evident behavioural effects were absent. This is a preview of subscription content, log in via an institution to check access. Institutional subscriptions. Unable to display preview. Download preview PDF. Siegel R K. Google Scholar. Assessment of drugs for dependence potential and abuse liability: an overview. Self-administration of psychoactive substances by the monkey. Psychopharmacologia —48, Reinforcing effects of nicotine in humans and experimental animals responding under intermittent schedules of IV drug injection. Pharmacol Biochem Behav —, Falk J L. Production of polydipsia in normal rats by intermittent food schedule. Science —, Schedule-induced oral narcotic self-administration acute and chronic effects. J Pharmacol Exp Ther —, Tang M, Falk J L. Ethanol dependence as a determinant of fluid preference. Oral self-administration of cocaine: chronic excessive intake by schedule induction. Schedule induction of drug intake: differential responsiveness to agents with abuse potential. Pharmacol Exp Ther —, CAS Google Scholar. Effect of some self-selection conditions on the voluntary alcohol intake of rats. Quart J Stud Alc —, A spontaneous opiate addiction in rhesus monkeys. How rats can become dependent on morphine in the course of relieving another need. In: Scientific basis of drug dependence, edited by Steinberg H. Churchill Ltd. Voluntary morphine ingestion, morphine dependence, and recovery from withdrawal signs. Article Google Scholar. Age and lack of handling as factors in the consumption of an etonitazene solution by naive rats. Arch Int Pharmacodyn —, Possibility of spontaneous drug abuse tested in rat. Pharmacol Res 28 1 —34, Myers R D. Alcohol choice in Wistar and G-4 rats as a function of environmental temperature and alcohol concentration. J Comp Physiol Psychol —, La polidipsia da condizionamento aggiuntivo o da angiotensina centralmente somministrata quale modello di dipendenza da oppiacei. A method for determining loss of pain sensation. J Pharmacol Exp Ther —79, Involvement of the caudatus nucleus, amygdala or reticular formation in neuroleptic and narcotic catalepsy. Effect of various central biogenic amine-modifiers and ambient temperature on the naloxone-induced jumping in morphine-dependent mice. Raven Press, New York, , pp — Factors regulating oral consumption of an opioid etonitazene by morphine-addicted rats. Psychopharmacologia —76, Grant S, Redmond D E. Clonidine suppresses methylxanthine induced quasi-morphine withdrawal syndrome. Ronnback L. Morphine preference in individual rats after morphine ingestion. Psychopharmacology —, Self-administration of barbiturates and benzodiazepines: a review. Schedule-induced cocaine drinking: choice between cocaine and vehicle. George F R. Genetic approaches to studying drug abuse: correlates of drug self-administration. Alcohol —, Download references. Sala, D. Braida, M. Colombo, M. You can also search for this author in PubMed Google Scholar. Alessandro Tagliamonte M. Professor of Pharmacology Professor of Pharmacology. Icro Maremmani M. Reprints and permissions. Sala, M. In: Tagliamonte, A. Springer, Vienna. Publisher Name : Springer, Vienna. Print ISBN : Online ISBN : Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Policies and ethics. Skip to main content. Drug Addiction and Related Clinical Problems. Summary Given that the techniques used to test drug abuse liability are not free from criticism, a series of oral free-choice experimental procedures was adopted. Access this chapter Log in via an institution. Chapter EUR Softcover Book EUR Tax calculation will be finalised at checkout Purchases are for personal use only. Preview Unable to display preview. Aversion-resistant fentanyl self-administration in mice Article 23 November Effects of imidazoline agents in a rat conditioned place preference model of addiction Article Open access 08 January References Siegel R K. Gori Authors M. Sala View author publications. View author publications. Rights and permissions Reprints and permissions. About this paper Cite this paper Sala, M. Copy to clipboard. Publish with us Policies and ethics. Search Search by keyword or author Search. Navigation Find a journal Publish with us Track your research.