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Drug consumption is a global issue with wide-ranging impacts on public health, social well-being, and economic stability. While alcohol and cannabis are among the most commonly used substances worldwide, illicit drug use remains a significant concern in many countries, as reports show on the website of the World Population Review organization. The United States leads in drug consumption, with a significant proportion of its population engaging in illicit drug use. Various factors contribute to high rates of illicit drug use in certain countries. The allure of forbidden substances, stringent drug laws, socioeconomic disparities, and geographic proximity to drug-producing regions all play a role. Additionally, stressors such as economic instability, political unrest, and public health crises like the COVID pandemic exacerbate drug consumption trends. The United States holds the title of being the foremost consumer of drugs globally, while Afghanistan stands out as the primary producer. Similarly, the bulk of coca cultivation, and consequently cocaine production, is concentrated in Colombia, Bolivia, and Peru. Afghanistan's dominance in opium production may face challenges in the future. The Taliban, in power, has expressed strong opposition to the opium trade and has enforced a ban on poppy cultivation. However, eradicating the industry entirely presents significant obstacles. Despite efforts, Afghanistan's poppy cultivation has been increasing steadily, reachin g , hectares , acres in —enough to yield tons of heroin. However, the press release lacks precise statistics to support this assertion and instead references data from earlier years. In , just 2. This data exclusively pertains to opiates and does not encompass information on opioids. In the global ranking of drug consumption, Kazakhstan secured the 8th position, while Uzbekistan ranked 95th. The rankings for other Central Asian countries are as follows:. This shift in ranking may be attributed to the Taliban's extensive efforts to provide mass treatment for drug addicts and enforce the prohibition of drug cultivation. Follow Daryo's official Instagram and Twitter pages to keep current on world news. Send Cancel. Thank you. We have received your message and will fix the error as soon as possible. Sign in Latest news Top headlines Most read Columnists. Latest news Top headlines Most read Columnists. USD Google play App Store Telegram. Telegram Youtube Facebook Instagram Twitter. Kazakhstan ranks among top 10 nations in drug consumption. As per to the United Nations' World Drug Report, cannabis is the most widely cultivated possibly illicit drug globally, followed by opium and cocaine. Cannabis cultivation spans countries and territories, highlighting its prevalence despite legal restrictions. Disability-Adjusted Life Years DALYs , a measure of the impact of drug use on public health, reveal significant health burdens associated with illicit drug consumption. Khadicha Abdurashidova. On this topic. Uzbekistan's Ministry of Health sets to regulate pharmaceutical ads on TV and radio 25 January, Marriage and divorce rates for CIS countries: divorces increase, marriages decrease 18 February, Ramzan Kadyrov's son becomes youth minister in Chechen Republic 18 February, G7 commits to maintain freeze on Russia's assets 18 February, Comments 0 Sign in. Leave A Reply Cancel. What are we going to search for? Welcome Back! Login below or Register Now. Facebook Google. Remember me. Register Now Already registered? Found an error in the text? Keep going.

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Official websites use. Share sensitive information only on official, secure websites. Corresponding author: Don C. Preventing HCV infection among people who inject drugs is a difficult public health challenge. We examined the potential role of intranasal drug use in reducing HCV acquisition. Subjects were recruited from IDUs entering the Beth Israel drug detoxification program from — A structured interview was administered and serum samples were collected for HCV testing. Encouraging intranasal use as an alternative to injection among persons currently injecting drugs may be a viable strategy for reducing HCV transmission. Hepatitis C virus HCV infection in people who inject drugs or injecting drug users IDUs 1 again present a very difficult challenge to public health systems. Treatment for HCV infection is costly, and IDUs are less likely to receive care and treatment of the infection than other patients Grebely et al. There have been a moderate number of studies of HCV prevention among IDUs, both at the population level and at the individual level. Interventions to reduce HIV transmission, most notably syringe exchange programs, were implemented in many high-income countries in the early to mids. A meta-analysis of pre versus post HCV prevalence studies in high income countries did find statistically significantly lower prevalence among IDUs in the post studies. Hagan and colleagues Hagan et al. This meta-analysis included 26 eligible studies of behavioral interventions, substance use treatment, syringe access, syringe disinfection, and multi-component interventions in which the intervention group subject simultaneously participated in more than one intervention. Only the combined intervention category showed a statistically significant pooled effect size. However, there were only two studies in this category, so that additional studies are needed to more fully examine the effectiveness of combined interventions. HCV is sufficiently easy to transmit that it can be transmitted through sharing of injection preparation equipment filters, cookers, rinse water in addition to sharing needles and syringes Hagan et al. Gillies and colleagues Gillies et al. We report here that intranasal drug use among persons who are also injecting drugs may have a substantial and persistent protective effect against HCV infection. The data reported here are derived from data collected from drug users entering the Beth Israel Medical Center drug detoxification program in New York City. The Beth Israel detoxification program serves the city as a whole, and approximately half of its patients live in Manhattan, one quarter in Brooklyn, one fifth in the Bronx, and the remainder i. Patients enter the program voluntarily. Research staff visited the general admission wards of the program in a preset order and examined all intake records of a specific ward to construct lists of patients admitted within the prior 3 days. All of the patients on the list for the specific ward were then asked to participate in the study. After all of the patients admitted to a specific ward in the three-day period had been asked to participate and interviews had been conducted among those who agreed to participate, the interviewer moved to the next ward in the preset order. Because there was no relationship between assigning patients to wards and the order that the staff rotated through the wards, these procedures would yield an unbiased sample of persons entering the detoxification program. A structured questionnaire covering demographics, drug use, sexual risk behavior, and use of HIV prevention services was administered by a trained interviewer. Most drug use and HIV risk behavior questions referred to the 6 months prior to the interview. Subjects were queried about using different drugs by different routes of administration, so that it was possible to determine if the same drug was being used through different routes of administration. Questions included the frequency of the use of different drugs and different routes of administration in the previous 6 months. Subjects were also asked if they had ever been in methadone maintenance, had ever been tested for HIV prior to the test administered in this study , and had ever been tested for HCV again prior to test administered in this study. The questionnaire included date of birth and age when illicit drugs were first injected to determine the number of years of injecting. Serial cross-sectional data have been collected in the project since We did permit individuals to participate in the study in different years. For the analyses reported here, however, we used only the first interview from persons who participated more than once. Both injecting and non-injecting drug users were recruited into the study, but only data from injecting users subjects who reported injecting in the month prior to entry into the detoxification program are analyzed in this report. Univariate predictors of being HCV seropositive were first identified, and multivariate logistic regression was then used to develop a theoretically informed model of factors independently associated with being HCV seropositive. Seven hundred and twenty-six active injecting drug users participated in the study between and Demographic characteristics, drug use behaviors and HCV serostatus are presented in Table 1. There was considerable variety in the patterns of drug use. HCV serostatus was not associated with recent intranasal cocaine use or recent smoking of crack cocaine. Four classes of variables length of injecting career, demographic characteristics, use of prevention services, and recent drug use behaviors were associated with HCV serostatus in the univariate analyses. As presented in the methods section, we used multiple logistic regression to develop a theoretically informed model of statistically independent factors associated with HCV serostatus in this sample. Potential predictors were entered by the four classes noted above, and by the strength of their univariate associations within each class. If a factor added to the model was not significantly associated with HCV serostatus it was not retained. As years injecting is typically the strongest predictor of HCV serostatus among IDUs, we first entered years injecting as a continuous variable into the model. As age was highly correlated with years injecting, we did not add it to the model to avoid multi-collinearity problems. Use of HIV prevention services may be associated with HCV serostatus through either a protective effect protecting against HCV infection or through a self-selection effect highest risk persons self-selecting to use the services and the services from Table 2 were added to the model in order of the strength of their associations with HCV serostatus. Finally, we added the drug use behaviors in the 6 months prior to the interview Table 2 , again in the order of the strength of their association with HCV serostatus. The final model is shown in Table 4. This model had the lowest Akaike Information Criterion value of all the models examined. For the variables that were retained in the multivariate model, the univariate ORs and the adjusted ORs were quite similar. Figure 1 shows HCV seroprevalence by each years-of-injecting category and for subjects who did and did not report recent intranasal heroin use within each years of injecting category. For 4 of the 5 injecting-years categories, HCV prevalence is lower among subjects who reported recent intranasal heroin use. The difference in HCV prevalence by recent intranasal heroin use was significant in both univariate analyses Table 2 and multivariate analysis Table 4. The data reported here should be considered in the context of other studies of route of drug administration and transmission of blood-borne viruses. There are reports of injecting drug users who ceased injecting but continued using drugs through non-injecting routes of administration in New York Des Jarlais et al. Des Jarlais, Casriel and colleagues Des Jarlais et al. The intervention consisted of four 2-hour group sessions over a 1-month period led by trained drug counselors. The intervention group did have a significantly lower rate of transition to injecting during the 9 month follow-up period Des Jarlais et al. Dolan and colleagues Dolan et al. The intervention consisted of five 1-hour sessions of individual therapy with a registered psychologist. At the 6 month follow-up, half of the subjects reported non-injecting drug use, but follow-up data were available for only 10 of the 30 subjects who began the program, and with services provided by a registered psychologist on a one-to-one basis, cost would clearly be an important factor. An initial evaluation showed positive attitude changes, and the program has been replicated in several countries USAID, , but has not yet been rigorously evaluated. This is consistent with data from other areas showing that very high-risk injectors are particularly likely to self-select into HIV prevention services Hagan et al. Several limitations of the present study should be noted. First, and perhaps most importantly, the design is cross-sectional, so that causal inferences between intranasal drug use and a lower likelihood of being HCV cannot be determined from these data. There are several potential causal explanations for the association observed here. At an event level, substituting an occasion of intranasal use for an occasion of injecting use would certainly reduce the chances of HCV transmission. See Mateu-Gelabert et al. At a social network level, persons who use heroin through both injecting and intranasal use may preferentially associate with others who have the same combined drug use patterns. As HCV prevalence is generally lower among persons with the combined drug use pattern, this would lead to a smaller likelihood of exposure to HCV if drug injection equipment were shared within these social networks. Social networks that contained peers who used drugs both through injection and non-injecting routes of administration might also provide support to each other to avoid exclusively injecting. Thus, differential networks might also be a contributing cause to the association between non-injecting drug use and the lower likelihood of being HCV seropositive. Longitudinal research would be needed to assess these different potential causal pathways. The different potential pathways are not mutually exclusive; indeed, they may be complementary. Randomized clinical trials of an intervention that effectively increased the frequency of intranasal drug use among already injecting drugs might be needed to rigorously evaluate the underlying causal pathways. A second limitation is that some HCV seropositives and some HCV seronegatives may leave the active drug injecting population over time, so that interpretation of the relationships between years injecting and HCV seroprevalence must be made with caution. However, the positive association between years injecting and HCV seropositive status observed here is similar to that observed in many other studies Hagan et al. Third, intranasal drug use was assessed for the 6 months prior to the interview, and exposure to HCV undoubtedly occurred prior to the 6-month period for the great majority of HCV seropositive subjects. There may have been variation over time in intranasal drug use. Individual subjects may have had periods of injecting and intranasal drug use, periods of only injecting, periods of only intranasal use, as well as periods with no drug use. The observed relationships thus indicate the existence of some consistent, long-term factors that would link recent routes of drug administration with HCV serostatus. Fourth, we did not ask why the subjects also used drugs through non-injecting routes of administration in addition to injecting. In a previous study of persons who had ceased injecting but continued to use drugs through non-injecting routes of administration including intranasal heroin , we found a considerable variety of reasons for ceasing to inject, including concerns about AIDS, other health problems associated with injecting, the belief that it is easier to control drug use through non-injecting routes of administration, that non-injecting use is more socially acceptable, and the belief that it is easier to conceal non-injecting use from others Des Jarlais et al. We would therefore assume that there would also be a considerable variety of reasons why the subjects in this study would have combined non-injecting drug use with injecting drug use. Fifth, the research was conducted at a single site in a single city, so that replication in other locations is needed. Patterns of non-injecting drug use may vary greatly with local conditions, such as the availability and price of heroin and presence of social networks of intranasal users. These environmental factors may greatly influence the numbers of IDUs who are able to substitute non-injecting drug use for injecting drug use. Despite these limitations, the present study makes several contributions to the possibility of non-injecting drug use as a viable strategy for reducing blood-borne viral infections among persons who inject drugs. Second, the inverse association was measured with a biological outcome HCV prevalence rather than simply with self-reported risk behaviors. Third, the inverse association was observed in persons who were currently injecting drugs, implying that it may not be necessary to completely cease injecting to reduce the likelihood of HCV infection. Given the many difficulties in preventing HCV infection among persons who inject drugs and the high morbidity and mortality associated with HCV infection, these findings suggest much more attention should be paid to substituting intranasal drug use for injecting drug use. Reaching injectors before they became infected with HCV would be most effective at preventing new HCV infections, though reducing HCV transmission behavior among persons who were chronically infected should also have an effect to reduce population-level transmission. However, this paper addresses official classification of HIV transmission routes, so that we will use the current standard terms injecting drug use and injecting drug users and the abbreviation IDU. We do want to emphasize that HIV prevention for persons who inject drugs should be based on full consideration of their human rights. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. As a library, NLM provides access to scientific literature. Drug Alcohol Depend. Published in final edited form as: Drug Alcohol Depend. Find articles by Don C Des Jarlais. Find articles by Holly Hagan. Find articles by Kamyar Arasteh. Find articles by Courtney McKnight. Find articles by Salaam Semaan. Find articles by David C Perlman. Issue date Dec PMC Copyright notice. The publisher's version of this article is available at Drug Alcohol Depend. Open in a new tab. White 0. White 1. Similar articles. Add to Collections. Create a new collection. Add to an existing collection. Choose a collection Unable to load your collection due to an error Please try again. Add Cancel. Average years of injecting sd. Ever in Methadone Maintenance Treatment Program. Last 6 month use of Syringe Exchange.

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Can Intranasal Drug Use Reduce HCV Infection among Injecting Drug Users?

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