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Crack cocaine is an illicit drug derived from cocaine. It can produce some damages to the lungs and oral cavity. Objective: The aim of this study was to analyze the frequency of micronuclei and some nuclear alterations in epithelial cells of crack cocaine users. Methods: Oral smears were collected from clinically normal-appearing buccal mucosa exfoliative cytology of 30 individuals 15 crack cocaine users and 15 controls. Results: Crack cocaine users consumed about 3. The prevalence of micronuclei, binucleated cells, broken egg cells, budding cells, picnosis, karyolysis, and karyorrhexis was determined. The frequencies of micronuclei for case and control groups were, respectively, 2. No statistical difference was observed for binucleated cells, broken egg cells, budding cells, picnosis, and karyolysis. The frequency of karyorrhexis was significantly increased on crack cocaine users than controls Conclusion: Smoke crack might have a cytotoxic and genotoxic effects to the oral mucosa due to increased frequency of micronuclei and karyorrhexis. Thus, individuals who used crack cocaine in the long term need to be frequently examined in order to prevent neoplastic transformation. J Dent Indones. To view the content in your browser, please download Adobe Reader or, alternately, you may Download the file to your hard drive. Advanced Search. Privacy Copyright. Skip to main content. Abstract Crack cocaine is an illicit drug derived from cocaine. Recommended Citation de Lima, R. Select an issue: All Issues Vol. Digital Commons.

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Main content 1 Search 2 Footer 3. Home Search Salivary protein candidates for biomarkers of oral disorders in people with a crack cocain Salivary protein candidates for biomarkers of oral disorders in people with a crack cocaine use disorder. Faculdade de Odontologia de Bauru. Responsible library: BR1. Biomarkers ; Crack cocaine ; Proteomics ; Salivary proteins and peptide. Add to My VHL. Search on Google. Your name Your email Send to. This page Selected references 0.

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