In utero exposure to poisons and drugs e. The major protein interacting with these compounds is butyrylcholinesterase BuChE , which attenuates the effects of such xenobiotics by their hydrolysis or sequestration. Therefore, we studied BuChE expression during placental development. However, cytochemical staining detected primarily BuChE activity in first-trimester placenta but AChE activity in term placenta. However, BuChE in the serum of a heterozygote and a homozygous normal were similar in their drug affinities. Therefore, heterozygous serum or placenta can protect the fetus from drug or poison exposure, unlike homozygous atypical serum or placenta. Genotype analyses revealed that heterozygous carriers of atypical BuChE were threefold less frequent among 49 patients with placental malfunction than among 76 controls or the entire Israeli population. These observations exclude heterozygote carriers of atypical BuChE from being at high risk for placental malfunction under exposure to anticholinesterases. This is a preview of subscription content, log in via an institution to check access. Rent this article via DeepDyve. Institutional subscriptions. Balasubramanian, A. Have cholinesterases more than one function? Trends Neurosci. Google Scholar. Booth, A. An improved method for the preparation of human placental syncytiotrophoblast. Placenta 1: — Chasnoff, I. Cocaine use in pregnancy. Chatonnet, A. Comparison of butyrylcholinesterase and acetylcholinesterase. Time to pregnancy and occupational exposure to pesticides in fruit growers in The Netherlands. Ehrlich, G. Genomics — Gatley, S. Activities of the enantiomers of cocaine and some related compounds as substrates and inhibitors of plasma butyrylcholinesterase. Guller, S. Steroid metabolizing enzymes associated with the microvillar membrane of human placenta. Steroid Biochem. Hahn, T. Location and activities of acetylcholinesterase and butyrylcholinesterase in the rat and human placenta. Jbilo, O. Tissue distribution of human acetylcholinesterase and butyrylcholinesterase messenger RNA. Toxicon — Jeong, T. Role of metabolism by esterase and cytochrome P in cocasine-induced suppression of the antibody response. Jones, C. Ultrastructure of the normal human placenta. Electron Microsc. Karnovsky, M. A direct coloring thiocholine method for cholinesterases. Karpel, R. Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins. Cell Res. Khalfoun, B. Characterization of the human syncytiotrophoblast plasma membrane associated components. Layer, L. Novel functions of cholinesterases in development, physiology and disease. LeDuc, B. Cocaine toxicity in cultured chicken hepatocytes: Role of cytochrome P Lev-Lehman, E. Antisense inhibition of acetylcholinesterase gene expression causes transient hematopoietic alterations in vivo. Gene Ther. Levene, C. Genetic polymorphisms among Bukharan and Georgian Jews in Israel. Liao, J. Monoclonal antibodies against brain acetylcholinesterase which recognize the subunits bearing the hydrophobic anchor. Lockridge, O. Genetic variants of serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. Part 1: Genetic variant of human acetylcholinesterase. Shafferman and B. Velan, Eds. Loewenstein, Y. Molecular dissection of the cholinesterase domains responsible for carbamate toxicity. Loewenstein-Lichtenstein, Y. Nature Med. MacGregor, S. Cocaine use during pregnancy: Adverse prenatal outcome. Molecular and cellular biology of the cholinesterases. May, D. Genetic differences in drug disposition. McGuire, M. Identification of the structural mutation responsible for the dibucaine-resistant atypical variant form of human serum cholinesterase. USA — Neville, L. Anionic site interactions in human butyrylcholinesterase disrupted by two adjacent single point mutations. Intramolecular relationships in cholinesterases revealed by oocyte expression of site-directed and natural variants of human BCHE. EMBO J. Peretti, F. Cocaine fatality: An unexplained blood concentration in a fatal overdose. Prody, C. Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues. Rachmilewitz, J. H19 expression and tumorigenicity of choriocarcinoma derived cell lines. Oncogene — Rakonczay, Z. Biochemistry and pathophysiology of the molecular forms of cholinesterases. In Subcellular Biochemistry J. Harris, Ed. Rama Sastry, B. Cholinergic systems in non-nervous tissues. Ratner, D. Chronic dietary anticholinesterase poisoning. Roe, D. Metabolism of cocaine by human placentas: Implications for fetal exposure. Schwarz, M. Engineering of human cholinesterases explains and predicts diverse consequences of administration of various drugs and poisons. Successive organophosphate inhibition and oxime reactivation reveals distinct responses of recombinant human cholinesterase variants. Brain Res. Seidman, S. Cell Biol. Sherman, J. Chlorphyrifos dursban associated birth defects report of four cases. Health Int. Simone, C. Acetylcholinesterase and butyrylcholinesterase activity in the human term placenta: Implications for fetal cocaine exposure. Soreq, H. Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G, C-rich attenuating structure. Szeinberg, A. High frequency of atypical pseudocholinesterase among Iraqi and Iranian Jews. Tabacova, S. Environmental pollutants in relation to complications of pregnancy. Health Perspect. Valentino, R. Prediction of drug sensitivity in individuals with atypical serum cholinesterase based on in vitro biochemical studies. Volpe, J. Effect of cocaine use on the fetus. Whittaker, M. Cholinesterases , Karger, Basel. Whyte, A. Biochemistry of the human syncytiotrophoblast plasma membrane. In Biology of Trophoblast Y. Loke and A. Whyte, Eds. Wu, D. Choline acetyltransferase: Celebrating its fiftieth year. Zakut, H. Chorionic villi cDNA library displays expression of butyrylcholinesterase: Putative genetic disposition for ecological danger. Download references. You can also search for this author in PubMed Google Scholar. Reprints and permissions. Sternfeld, M. Cell Mol Neurobiol 17 , — Download citation. Issue Date : June Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Cellular and Molecular Neurobiology Aims and scope Submit manuscript. Abstract 1. Access this article Log in via an institution. Efflux transporters in rat placenta and developing brain: transcriptomic and functional response to paracetamol Article Open access 06 October Characterization of a human placental clearance system to regulate serotonin levels in the fetoplacental unit Article Open access 23 August Developmental expression of catecholamine system in the human placenta and rat fetoplacental unit Article Open access 23 March Google Scholar Booth, A. Google Scholar Chasnoff, I. Google Scholar Chatonnet, A. Google Scholar de-Cock, J. Google Scholar Ehrlich, G. Google Scholar Gatley, S. Google Scholar Guller, S. Google Scholar Hahn, T. Google Scholar Jbilo, O. Google Scholar Jeong, T. Google Scholar Jones, C. Google Scholar Karnovsky, M. Google Scholar Karpel, R. Google Scholar Khalfoun, B. Google Scholar Layer, L. Google Scholar LeDuc, B. Google Scholar Lev-Lehman, E. Google Scholar Levene, C. Google Scholar Liao, J. Google Scholar Lockridge, O. Google Scholar Loewenstein, Y. Google Scholar Loewenstein-Lichtenstein, Y. Google Scholar MacGregor, S. Google Scholar May, D. Google Scholar McGuire, M. Google Scholar Neville, L. Google Scholar Peretti, F. Google Scholar Prody, C. Google Scholar Rachmilewitz, J. Google Scholar Rakonczay, Z. Google Scholar Rama Sastry, B. Google Scholar Ratner, D. Google Scholar Roe, D. Google Scholar Schwarz, M. Google Scholar Seidman, S. Google Scholar Sherman, J. Google Scholar Soreq, H. Google Scholar Szeinberg, A. Google Scholar Tabacova, S. Google Scholar Valentino, R. Google Scholar Volpe, J. Google Scholar Whittaker, M. Google Scholar Whyte, A. Google Scholar Wu, D. Google Scholar Zakut, H. Google Scholar Download references. View author publications. Rights and permissions Reprints and permissions. About this article Cite this article Sternfeld, M. Copy to clipboard. Search Search by keyword or author Search. Navigation Find a journal Publish with us Track your research.

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In utero exposure to poisons and drugs (e.g., anticholinesterases, cocaine) is frequently associated with spontaneous abortion and placental malfunction.

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