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We use cookies on our website to help us understand how you use the site and to make improvements. These may be used to track your visit to our website or to enable us to personalise your browsing experience, and they may be shared with Google Analytics so that your data can be processed. Privacy and cookies policy. The time has now come f or unify in g these two separate w or lds and The Lancet family of journals can play a unique role in sett in g the research—and policy—agenda. The Global Nutrition Rep or t published in September tracks progress towards eight in dicat or s of nutrition status that have been end or sed by the W or ld Health Assembly: four relat in g to undernutrition and four to overweight, obesity, and diabetes. The good news is that there has been progress in reduc in g malnutrition in all its In dicat or def in itions: While all in dicat or s were def in ed as they appear in global guidel in es, delv in g in to various sources f or district-level data and compar in g them with each other meant that some of these def in itions had to be altered slightly to the data available. Vitam in A supplementation, f or in stance, used data f or month children in one official rep or t and data f or month children in another Privacy and cookies policy We use cookies on our website to help us understand how you use the site and to make improvements. The challenge to nutrition researchers everywhere: identify a set of actions that reduce malnutrition in all its f or ms Tak in g the nutrition conversation to the district-level in In dia: Data challenges are likely to constra in multisect or al action f or nutrition Previous 5 of 5.

Safety and immunogenicity of the anti-cocaine vaccine UFMG-VAC-V4N2 in a non-human primate model

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A promising strategy for cocaine addiction treatment is the anti-drug vaccine. These vaccines induce the production of anticocaine antibodies, capable of linking to cocaine, and decrease the passage of cocaine throughout the blood-brain barrier, decreasing drug activity in the brain. This study assessed the safety and immunogenicity of the anti-cocaine vaccine UFMG-VAC-V4N2 in a non-human primate toxicity study using single and multiple vaccine doses. The UFMG-VAC-V4N2 yielded only mild effects in the injection site and did not influence the general health, feeding behavior, or hematological, renal, hepatic, or metabolic parameters in the vaccinated marmosets. This preclinical UFMG-VAC-V4N2 study responds to the criteria required by international regulatory agencies contributing to future anticocaine clinical trials of this anti-cocaine vaccine. Keywords: Anti-drug vaccine; Anticocaine vaccine; Cocaine use disorder; Preclinical study; Safety study. Abstract A promising strategy for cocaine addiction treatment is the anti-drug vaccine. Publication types Research Support, Non-U. Substances Antibodies Cocaine Vaccines.

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Safety and immunogenicity of the anti-cocaine vaccine UFMG-VAC-V4N2 in a non-human primate model

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