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John Luque, Ph. Studies in the U. This pilot mixed-methods study was with adult medical marijuana patients. In phase 1 the researchers used an adapted version of a previously validated patient survey in medical marijuana treatment centers to explore the therapeutic benefits of medical marijuana for pain alleviation, overall well-being and other beneficial effects in a diverse patient population. Findings from phase 2 interviews revealed participants would cease using several prescription drugs for pain, anxiety and medical problems after becoming medical marijuana patients. Secondly, 13 diverse participants 7 Whites, 3 Blacks, 2 Hispanic and 1 Asian ranging in age from , with the average age of 38 were interviewed in person or over the phone. The study consisted of a mixed-methods approach including an online statewide survey and qualitative open-ended interviews of a small sample of diverse patients to: 1 determine the social, economic, and health-related factors impacting the use of medical marijuana by patients; and 2 evaluate perceived therapeutic benefits of medical marijuana by minority patients, as well as the preference for medical marijuana administration e. Statistically significant differences were found by ethnicity. In terms of perceived benefits or preference for administration, the researchers did not identify any differences based on race and ethnicity of the patients. Most patients preferred vaping for administration. All patients commented on how expensive it is to obtain medical marijuana. Impact on MMERI MMERI may wish to educate shareholders on the need to understand patient's attitudes toward the use of medical marijuana, as well as vaping as a preferred method, and the potential barrier of cost. Contact Us Forum Registration Here. Call Us Contact Us. Click here to learn more. MLK, Jr. Methodology The study consisted of a mixed-methods approach including an online statewide survey and qualitative open-ended interviews of a small sample of diverse patients to: 1 determine the social, economic, and health-related factors impacting the use of medical marijuana by patients; and 2 evaluate perceived therapeutic benefits of medical marijuana by minority patients, as well as the preference for medical marijuana administration e. Findings and Implications Results Statistically significant differences were found by ethnicity. Applied Research Impact on MMERI MMERI may wish to educate shareholders on the need to understand patient's attitudes toward the use of medical marijuana, as well as vaping as a preferred method, and the potential barrier of cost. Educate Take the free online Educational Module Course. Learn Get the latest information. Talk Join Conversations on Cannabis each month.

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CUD, which affects one in five people who use cannabis, leads to problems such as withdrawal symptoms and cravings when not using cannabis, difficulty reducing cannabis use and a need to consume more of the drug to experience the same effects. THC metabolism, the process by which this active component gets broken down in your body into psychoactive and inactive components, can be influenced by genetic differences in enzymes. About one in four people have a gene that causes these enzymes to break down THC less effectively than others, which can increase the strength and duration of the effects of cannabis. Differences in metabolism have been linked to an increased risk for substance use disorder for other drugs but not yet cannabis. For their study, the researchers recruited 38 young adults ages with CUD and 16 with a non-CUD substance use disorder. This age group was chosen as they are three times more likely to have CUD than teens or adults over 26 who use cannabis. Blood samples were collected from study participants, and gene variants for THC-metabolizing enzymes were tested. Participants also completed a questionnaire designed to measure their reported positive and negative effects from cannabis use. Based on their gene variant, participants were categorized as either normal or slow THC metabolizers. The researchers then correlated metabolism with the subjective effects reported by the participants. Notably, the study showed that young females with CUD were more likely to be slow metabolizers of THC compared to young females with other non-CUD substance use disorders. This suggests that young females who metabolize cannabis more slowly may be at higher risk for developing CUD. When looking at young adult males, the researchers found that those who had a gene variant contributing to slower THC metabolism reported more negative effects during initial cannabis use, like drowsiness, laziness and difficulty concentrating. Overall, participants of both sexes who were categorized as slow metabolizers of THC experienced more negative effects during recent cannabis use. Although the study recruited young adults, the most important implications of its findings may be for teens. Many young adults who develop CUD start using cannabis in their teens. As the social acceptance of cannabis grows and its perceived risk diminishes, teens may use cannabis more if they are not aware of potential harms. The study highlights that not all young people who use cannabis experience the drug the same way, and that how people metabolize THC may be one factor that could contribute to risk for CUD. Although slower THC metabolizers experience more negative effects, the experience of simultaneous positive effects may lead them to continue cannabis use regardless of bad outcomes. Tomko and Davis believe it is important to educate teens about the differences in how people experience cannabis. For example, educational programs targeted to adolescents can improve their understanding of risk factors for CUD. The initial findings from this research may be particularly important in the context of the continual rise in cannabis potency that has been observed over the past couple of decades, as well as the availability of high-potency cannabis products in legal markets. With a lack of regulation of cannabis products, combined with an increase in acceptance of cannabis use, additional research to identify risk factors for CUD will be necessary to advise vulnerable groups, like adolescents. Evidence for sex differences in the impact of cytochrome P genotypes on early subjective effects of cannabis. Addict Behav. Epub Feb Categories: Research. A genetic difference in THC metabolism may explain why some young adults have negative experiences with cannabis Anna Tsyrulnikov. Young woman in tracksuit rolling a marijuana joint. Licensed from istockphoto. Christal Davis THC metabolism, the process by which this active component gets broken down in your body into psychoactive and inactive components, can be influenced by genetic differences in enzymes. Davis was surprised by the sex differences evident in the data. Rachel Tomko Although the study recruited young adults, the most important implications of its findings may be for teens.

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