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Бензидамин — Википедия

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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Benzydamine also known as Difflam or Tantum Verde is a topical anaesthetic of the indazole chemical class. It is sometimes found in small doses in over-the-counter products used to treat sore throats. In Germany and Poland, it is sold as a vaginal douching agent under the brand name Tantum Rosa. This product is also easily accessible across the world through the use of online stores such as eBay. Alternatively, benzydamine can be used as a powerful psychoactive hallucinogen for recreational purposes. In high doses, it acts as a unique deliriant and CNS stimulant. Benzydamine, or 3- 1-benzylindazolyl oxy-N,N-dimethylpropanamine, is a synthetic benzyl-indazole molecule. Benzydamine contains a benzene and pyrazole ring fused to form a bicyclic indazole group. This indazole ring is also substituted at R 3 with an ether chain consisting of the oxygen group bonded to a propyl amine chain. The terminal amine R N of this structure is substituted with two methyl groups dimethyl. Benzydamine is produced as a hydrochloride salt. Benzydamine is a locally acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties. In terms of the pharmacology behind its hallucinogenic effects, this aspect of benzydamine remains unstudied and is subject to much speculation. Benzydamine has a powerful reinforcing effect and that this effect is greatly facilitated in animals that already had substance experience, having previously self-administered heroin and cocaine , indicating cross sensitization between benzydamine and other common drugs of abuse. Benzydamine dose-dependently reduced both field excitatory post synaptic potential amplitude and paired pulse ratio, suggesting a presynaptic mechanism of action. Similarly to the in vivo paradigm, also the electrophysiological effects of benzydamine were potentiated in slices from animals that had undergone cocaine and heroin self-administration. Furthermore, benzydamine-induced Long Term Depression LTD -like responses in the prelimbic cortex-to-nucleus accumbens circuitry were significantly reduced in the presence of the CB1 receptor antagonist AM These findings provide firm evidence of the abuse liability of benzydamine and suggest a possible cannabinoidergic mechanism of action. You can help by expanding or correcting it. Anecdotal reports which describe the effects of this compound within our experience index include:. The vaginal douching agents such as Tantum Rosa and other products consistently contain large amounts of salt which, if consumed, can cause serious kidney damage. The toxicity and long-term health effects of recreational benzydamine use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because benzydamine is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried benzydamine suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly but nothing can be completely guaranteed. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. Benzydamine is usually extracted from Tantum Rosa douching agents which are available online. In order to consume the substance safely, one must first remove the dangerous levels of salt contained within the sachet. After the substance has mostly dissolved after stirring warm or just boiled water works best as the salt will dissolve more easily , wait 10 minutes. After 10 minutes has past the benzydamine should have formed a layer on the top and the salt have settled at the bottom. The benzydamine should be filtered out using filter paper but do not pour the salt that may settle at the bottom as this will simply add back most of the salt you have tried to remove. It is best to consume the remaining paste by stirring it into very strong squash and drinking it. Summary sheet: Benzydamine Benzydamine. Physical effects. Visual effects. Cognitive effects. Auditory effects. Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Community Network YouTube Good vibes. Summary sheet: Benzydamine. This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information.

Бензидамин — Википедия

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