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Hulking bodyguards loom over tables filled with wealthy Chinese merchants and the children of government officials. Stunning young prostitutes work the crowd, dancing lasciviously to deafening pop music. Sometimes their boyfriends pay; other times the girls get discounts on the drug, which they say loosens their inhibitions. I take these pills to make me happy. A world away in the U. They sent the three kids away, locked the doors and hid the car so no one would bug them. A friend recommended that they take ecstasy, except he called it MDMA and said therapists used it 20 years ago to get people to discuss difficult topics. So we know that ecstasy is versatile. The ready availability of ecstasy, from Phnom Penh to Grand Rapids, is a newer phenomenon. In the U. After being outlawed in the States in , it remained common only on the margins of societyin clubland, in gay America, in lower Manhattanwhile emerging as an integral part of rave culture in Europe. But in the past year or so, ecstasy has achieved a worldwide prominence unmatched by nearly any other drug. In Hong Kong and Singapore, where overall rates of drug abuse have been declining, ecstasy use has been rising precipitously. In Japan, police and customs agents seized 68, ecstasy pills in the first nine months of this yearfour times the number confiscated in all of In June, Hong Kong police hauled in , tablets in one raid. On May 12, U. Huge factories in China do a brisk trade in the chemicals necessary to produce ecstasy, which are shipped in bulk to Europe. For the moment, ecstasy is still a niche drug, even in the U. In most parts of Asia, heroin and amphetamines still dominate the lists of preferred drugs, and in many countriesincluding Vietnam, India and South Koreae has made few inroads into the local population. The biggest bust in Goa, famous for its full-moon beach raves, netted only 17 pills earlier this year. In the Loft, a Beijing club where old Cultural Revolution movies unspool on giant screens, pricey e tablets represent much more than status symbols. As long as you have money, you can be so happy in just a couple of minutes, says year-old Wang Aibing. In Thailand, which has been devastated by amphetamines known as yaa baa the way certain U. But yaa e fits right in with our whole lifestyle, the music, the fashions. Indeed, much of the ecstasy takingand the law enforcement under way to end ithas been accompanied by a breathlessness that sometimes misses the point. In censorious Malaysia, newspapers warn of ecstasy tablets mixed with ground glass and tell tales of young, scantily clad girls on e disappearing into vans in the wee hours of the morning. In the Philippines, commentators gleefully retell the story of a schoolgirl, supposedly aroused by ecstasy, lying down invitingly in the middle of a school fair. Ecstasy is popular because it appears to have few negative consequences. Why not enjoy it? That nonchalance could be dangerously naive. These are not just benign, fun drugs, says Alan Leshner, director of the U. National Institute on Drug Abuse. They carry serious short-term and long-term dangers. But one reason ecstasy is so fascinating, and thus dangerous to antidrug crusaders, is that it appears to be a safer drug than heroin and cocaine, at least in the short run, and appears to have more potentially therapeutic benefits. About half an hour after you swallow a hit of e, you begin to feel peaceful, empathetic and energeticnot edgy, just clear. Pot relaxes but sometimes confuses; LSD stupefies; cocaine wires. Ecstasy has none of those immediate downsides. Jack, 29, an American living in Indiana who has taken ecstasy about 40 times, says the only time he felt as good as he does on e was when he found out he had won a prestigious scholarship. E allows the mind to wander, but not into hallucinations. Users retain control. Jack can allow his social defenses to crumble on ecstasy. Qu, high on e at a Beijing club called Banana, wantonly drapes herself over her embarrassed boyfriend. We Chinese sometimes feel uncomfortable touching each other, she says, but with ecstasy, you feel like you can hug everybody without being worried. All this marveling should raise suspicions, however. And even as they help open the mind to new experiences, drugs also can distort the reality to which users ineluctably return. Is ecstasy snake oil? And how harmful is it? It is also unlike pretty much every other illicit drug. Ecstasy pills are or at least are supposed to be made of a compound called methylenedioxymethamphetamine, or MDMA. Instead, its chemists simply thought it could be a promising intermediary substance that might be used to help develop more advanced therapeutic drugs. Yet MDMA all but disappeared until The cold war was on, and for years its combatants had been researching substances as potential weapons. The Michigan study found that none of the compounds under review was particularly toxic. Broadly speaking, there are two dangers: first, a pill you assume to be MDMA could actually contain something else. Anecdotal evidence suggests that most serious short-term medical problems that arise from ecstasy are actually caused by pills adulterated with other, more harmful substances. In Indonesia pills are cut with anything from flour to laxatives to insect repellent. In Malaysia officials claim tablets are mixed with rat poison. Second, and more controversially, MDMA itself might do harm. MDMA causes these cells to disgorge their contents and flood the brain with serotonin. But forcibly catapulting serotonin levels could be risky. Of course, millions of people manipulate serotonin when they take Prozac. But ecstasy actually shoves serotonin from its storage sites, according to Dr. Prozac just prevents the serotonin that has already been naturally secreted from being taken back up into brain cells. Normally, serotonin levels are exquisitely maintained, which is crucial because the chemical helps manage not only mood but also body temperature. At such extremes, the blood starts to coagulate. In the past two decades, dozens of users around the world have died this way. There are long-term dangers, too. By forcing serotonin out, MDMA resculpts the brain cells that release the chemical. The changes to these cells could be permanent. Johns Hopkins neurotoxicologist George Ricaurte has shown that serotonin levels are significantly lower in animals that have been given about the same amount of MDMA as you would find in one ecstasy pill. Late last year, Ricaurte recorded for the first time the effects of ecstasy on the human brain. He gave memory tests to people who said they had last used ecstasy two weeks before, and he compared their results with those of a control group of people who said they had never taken e. The ecstasy users fared worse on the tests. Computer images that give detailed snapshots of brain activity also showed that e users have fewer serotonin receptors in their brains than nonusers, even two weeks after their last exposure. On the strength of these studies as well as a large number of animal studies, Ricaurte has hypothesized that the damage is irreversible. The major problem is that his research subjects had used all kinds of drugs, not just ecstasy. And there was no way to tell that the ecstasy they had taken was pure MDMA. And critics say that even if MDMA does cause the changes to the brain that Ricaurte has documented, those changes may carry no functional consequences. His findings should not be dismissed, but they may simply mean that we have a whole lot of plasticitythat we can do without serotonin and be O. He believes that the compound has a special ability to help people make sense of themselves and the world, that taking MDMA can lead people to inner truths. At that time, MDMA had a small following among avant-garde psychotherapists, who gave it to blindfolded patients in quiet offices and then asked them to discuss traumas. According to Shulgin who is often wrongly credited with discovering MDMA , another therapist to whom he gave the drug in turn named it Adam and introduced it to more than 4, people. One who was based in Texas hired a chemist, opened an MDMA lab and promptly renamed the drug ecstasy, a more marketable term than Adam or empathy his first choice, since it better describes the effects. Manufacturers at the time flaunted the legality of the drug, promoting it as lacking the hallucinatory effects of LSD and the addictive properties of coke and heroin. The U. Drug Enforcement Administration was caught by surprise by the new drug not long after it had been embarrassed by the spread of crack. The administration quickly used new discretionary powers to outlaw MDMA, pointing to the private labs and club use as evidence of abuse. DEA officials also cited rudimentary studies showing that ecstasy users had vomited and experienced blood-pressure fluctuations. Most therapeutic use quickly stopped. She believes e helped Shane find the right attitude to fight his illness, and she works with Doblin to advocate for limited legal use. Soon his association will help fund the first approved study of MDMA in psychotherapy, involving 30 victims of rape in Spain diagnosed with post-traumatic stress disorder. The first time Koon-hung, a Hong Kong toy salesman, took ecstasy, he says he lost his memory for about two minutes. The first time Ferry, a year-old computer programmer in Jakarta, tried the drug, his foot began to swell, his right hand went numb, he had trouble breathing and he ended up in the emergency room. The two most common short-term side effects of MDMAboth of which remain rare in the aggregateare overheating and something even harder to quantify, psychological trauma. A few users have mentally broken down on ecstasy, unprepared for its powerful psychological effects. You know the black mood is chemical, related to the serotonin, says Adrienne, 26, an American fashion-company executive who has used ecstasy almost weekly for the past five years. But the world still seems bleak. Some users, especially kids trying to avoid the pressures of growing up, begin to use ecstasy too oftenevery day in rare cases. Another downside: because users feel empathetic, ecstasy can lower sexual inhibitions. Men generally cannot get erections when high on e, but they are often ferociously randy when its effects begin to fade. Still, the majority of people who end up in the emergency room after taking ecstasy are almost certainly not taking MDMA but something masquerading under its name. The most common adulterants in such pills are aspirin, caffeine and other over-the-counters. Contrary to lore, fake e almost never contains heroin. But the most insidious adulterant is DXM dextromethorphan , a cheap cough suppressant that causes hallucinations in the mg dose usually found in fake e 13 times the amount in a dose of Robitussin. Because DXM inhibits sweating, it easily causes heatstroke. Another dangerous adulterant is PMA paramethoxyamphetamine , an illegal drug that in May killed two Chicago-area teenagers who took it thinking they were dropping e. As writer Joshua Wolf Shenk has pointed out, we tend to have opposing views about drugs: they can kill or cure; the addiction will enslave you, or the new perceptions will free you. Aldous Huxley typified this duality with his two most famous books, Brave New Worldabout a people in thrall to a drug called somaand The Doors of Perception, an autobiographical work in which Huxley begins to see the world in a brilliant new light after taking mescaline. Ecstasy can occasionally enslave and occasionally offer transcendence. Usually, it does neither. For Adrienne, the Midwesterner, ecstasy is a key part of life. E makes shirtless, disgusting men, a club with broken bathrooms, a deejay that plays crap and vomiting into a trash can the best night of your life, she says with a laugh. That is a versatile drug indeed. Contact us at letters time. Join Us. Customer Care. Reach Out. Connect with Us. Is Adrenal Fatigue Real? Home U. All Rights Reserved. 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