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By using our site, you agree to our collection of information through the use of cookies. To learn more, view our Privacy Policy. To browse Academia. Arterial plasma drug concentrations should be a strong predictor of resultant physiological and behavioral effects of smoked drugs. Nine healthy male volunteers, who were current users of smoked and i. Each volunteer was first tested under all dosing conditions without an arterial catheter phase I , to determine whether subjects could tolerate each cocaine dose, before testing with an arterial catheter phase II. Phase II consisted of two test days, each consisting of either four smoked-cocaine sessions sham, For the two highest doses for each route, arterial and venous blood samples were taken simultaneously before drug administration, during drug administration and frequently after drug administration. At the same time, cardiovascular Concerning any socioprofessional category, some addictive drugs like cocaine are responsible for many complications. The authors relate two case reports of young patients who suffered from cardiovascular accidents due to this drug. The first one was diagnosed with an ischemic stroke caused by carotid artery dissection and a leg distal vascular obliteration, the second one with a myocardial infarction with. Cocaine is more and more used and abused in France. Cocaine dependence is quite serious and is associated with numerous adverse health consequences. No effective pharmacotherapy for cocaine dependence is yet available. Recent advances in neurobiology, brain imaging and some clinical trials suggest that certain medications that modulate GABAergic, dopaminergic, and glutamatergic systems, as well as immunotherapy, show promise in the treatment of cocaine addiction. Pharmacological agents such as modafinil, GABAergic agents baclofen, topiramate, tiagabin, and vigabatrin , disulfiram, aripiprazole, N-acetylcysteine and cocaine vaccine seem very promising in the treatment of cocaine dependence. However, this must be confirmed in larger patient populations. A descriptive and analytical cross-sectional study was conducted to assess street drug use in an urban setting. The general aim of the study was to contribute to the fight against street drug consumption by identifying the determinants of drug use. The objectives of this paper are to describe the socio-demographic characteristics of street drug users, to determine the type of drugs purchased, and to identify the factors influencing drug purchase. Based on a sample of individuals, the study found that the use of street drugs is a widespread phenomenon, as shown by its prevalence in the surveyed population individuals out of a total of , i. The low cost of drugs was found to be the mai Background: Drug-drug interactions are a major cause and a source of iatrogenic events. Aim: To estimate the prevalence of drug-drug interactions in the cardiology department, describe and analyze them according to associated factors. Method: A prospective observational study during 5 months from February to June , at the medical cardiology department of Batna, was conducted on patients aged over 16 years who were admitted at least during 24 hours and received at least two drugs. Demographic and pharmacological data were collected using a validated and tested questionnaire. Descriptive statistics are generated and a univariate study is used to determine the associated factor International Journal of Innovation and Applied Studies, This prospective study was carried out over a period of one year at the Laboratory of Moroccan Poison Control and Pharmacovigilance Center. The plasma sample was submitted to a liquid-liquid extraction. The screening immunoassay and colorimetric tests have been applied to urine samples. The resul Aim: to estimate the prevalence of drug-drug interactions in the cardiology department, and describe and analyze them according to associated factors. Method: A prospective observational study during 5 months from February to June , at medical cardiology department of Batna was conducted in patients aged over 16 years who were admitted at least during 24 hours and received at least two drugs. Descriptive statistics is generated and a univariate study is used to determine the associated factors. The prevalence of drug-drug interactions was estimated at Age, number of comorbidities, number of medications are factors for drug-drug interactions. This difference is due to the fact that some studies were conducted in a single department while others in all departments of the hospital which may have a high level recruitment at low risk and therefore lower prevalence than those emerged in one department. Reconfiguraciones en la Argentina del siglo XXI, Log in with Facebook Log in with Google. Remember me on this computer. Enter the email address you signed up with and we'll email you a reset link. Need an account? Click here to sign up. Arterial and venous cocaine plasma concentrations in humans: relationship to route of administration, cardiovascular effects and subjective effects Edward Cone. Cocaine: From recreational use to dependence Michel Reynaud. Cocaine choice, a question of delay Ludivine Canchy. Drug-drug interactions: prospective study targeting department of cardiology Hocine Gacem. Methodology of therapeutic trials: lessons from the late evidence of the cardiovascular toxicity of some coxibs Philippe Ravaud , Florence Tubach. Drug-drug interactions: prospective study targeting department of cardiology - University Hospital of Batna Hocine Gacem. View publication stats. Direitodotrabalho Mariana Nigre. Hans J. Babpeluang Windi Sukma. Libro estadistica aplicada negocios Exchel Bouttier. Morselli, D. Morte da Arte hoje Rodrigo Duarte. Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness—ENIGMA study in individuals Martin Alda. Introduction to volume 2, fourth issue William Chao. Existence Laurent Chupin. Coupled oceanic oxygenation and metazoan diversification during the early—middle Cambrian? Thomas Algeo.
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But if carefully laid plans fall apart, you may still be able to recover. The FARC had waged its guerrilla war against the government of Colombia since , fighting for Marxist rule and agrarian reforms using conventional military operations and terrorist tactics. Peace negotiations repeatedly collapsed. An estimated , people died in the conflict, and more than five million were displaced by it, the New York Times reports. If Colombians longed for the conflict to end, many also wanted to ensure the guerrillas would be brought to justice for their crimes. Following many rounds of negotiations mediated by the Cuban government in Havana, the two sides signed a cease-fire accord in June and a peace deal on September In the agreement, the Colombian government promised to invest in rural development and aid the FARC in transforming itself into a legal political party with guaranteed representation in Congress. In return, the FARC said it would end its illegal drug trade, remove land mines, turn over its weapons to United Nations inspectors, and engage in community work and other acts of reparation. As stipulated by Santos, all that was needed was for Colombians to vote to ratify the deal in a referendum. The negotiators seemed to have little to worry about, as polls suggested that support for the agreement was high. But the polls were wrong. As it turned out, many voters agreed with Uribe that the deal was too soft on the guerrillas, according to the Times. Though shaken by the loss, the two sides quickly got back to the bargaining table, determined to make adjustments to win over critics of the deal. On October 7, they were emboldened by the news that Santos had been awarded the Nobel Peace Prize in support of his efforts to end the conflict. And after Donald J. Trump was elected president in the United States on November 8, Santos was particularly keen to have an agreement ratified while President Barack Obama, a supporter of the deal, was still in office. Negotiating around the clock, the government shuttled between conservative political leaders who had opposed the deal and FARC negotiators. In the end, the parties reached a deal that incorporates about 50 new changes designed to broaden its appeal. The revised agreement gives judges greater latitude in prosecuting drug trafficking by rebels and clearer protections for landowners in the countryside. However, it does not allow for tough prison sentences for rebels— an issue that the government believed to be a nonstarter for the rebels—nor does it completely bar those involved in war crimes from participating in politics, the Times reports. On November 30, the Congress voted to ratify the deal, even as its remaining opponents walked out of the chamber in protest. Click here to cancel reply. Your email address will not be published. Save my name, email, and website in this browser for the next time I comment. Preparing for Negotiation Understanding how to arrange the meeting space is a key aspect of preparing for negotiation. This discussion was held at the 3 day executive education workshop for senior executives at the Program on Negotiation at Harvard Law School. Remember Me This setting should only be used on your home or work computer. Lost your password? Create a new password of your choice. All rights reserved. Daily Blog. Program on Negotiation Harvard Law School. Leave a Reply Cancel reply Your email address will not be published. Stay Connected to PON. Preparing for Negotiation. Crisis Negotiation Lessons: The U.
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