BPC-157 - пептид

Информация про BPC-157 с трех разных сайтов.

Examine.com & selfached & livinglibations.com
Список статей не сохраняла.

BPC-157 is a synthetic peptide that is being investigated for its regenerative effects. It shows high efficacy for rats suffering toxic or surgical trauma, but there is currently little evidence that it provides benefits for people.

What are BPC-157’s main benefits?

More research is needed to determine whether BPC-157 has any potential benefits in humans. Studies conducted in rodents and cultured cells have suggested that BPC-157 may support the healing of various tissues, including tendons, joints, nerves, the intestinal tract, the stomach, and skin.[1][2][3]

What are BPC-157’s main drawbacks?

BPC-157’s potential drawbacks are uncertain, given the lack of human evidence. No clear toxicity or negative side effects have been reported in studies conducted in rodents,[4][5][1] but this research is limited. Therefore, the biggest drawback of BPC-157 is that there is insufficient evidence of its safety.

How does BPC-157 work?

BPC-157 has various possible (potentially overlapping) mechanisms of action, including promoting nitric oxide synthesis, activating cells involved in tissue repair, stimulating the synthesis of growth factors, and inhibiting inflammation.[2][6][7]

BPC-157 can be taken orally, topically, or via injection. Oral ingestion of peptides like BPC-157 wouldn’t normally be expected to have a direct effect on tissues outside of the gastrointestinal tract (like tendons and nerves) because peptides aren’t easily absorbed into circulation. However, studies in rodents have suggested that oral ingestion can have systemic effects, meaning that the feasibility of this route of delivery can’t be ruled out.[8]

What is BPC-157?

Body Protection Compound 157 (BPC-157) is a peptide composed of 15 amino acids. Although the researchers who patented BPC-157 say that it was derived from a stomach protein, this claim isn’t well-substantiated.[9] BPC-157 is thought to improve the repair of damaged tissues, although there is currently no human evidence to support this hypothesis.[1]

What are other names for BPC-157

Note that BPC-157 is also known as:

PL 14736

PL-10

Bepecin

BPC-157 should not be confused with:

TB-500

Dosage information

Medical disclaimer

The closest possible recommended dose is based on rat studies where oral administration showed benefit, as most studies administer the supplement via injection. The oral dose that was effective in rats, 10 μg/kg, is estimated to be equivalent to 1.6 μg/kg, or:

110 μg for a 150lb person

145 μg for a 200lb person

180 μg for a 250lb person

There are currently no human pharmacokinetic studies to assess species differences.

==========

What Is BPC 157?

BPC is a protein found in stomach acid and discovered in the ‘90s. BPC 157 is a 15-amino-acid-long fragment of this protein that is synthetically produced [1].

Some studies refer to BPC as “body protection compound,” hinting at its therapeutic potential. Scientists consider it a blueprint for an entirely new class of organ-protective/healing drugs, but research is still in the early stages [2, 1, 3].

How Does BPC 157 Work?

BPC 157 likely promotes muscle and tendon healing by triggering the formation of new blood vessels – a process called angiogenesis (by increasing VEGF). This explains its regenerative potential and why it might also help heal wounds, cuts, and other types of damage in the body [4, 5].

By increasing new blood vessels, it might help with IBD, in which healing of the inflamed gut lining is slow [6].

Additionally, BPC 157 may promote wound and tendon healing by blocking the growth-inhibiting effects of a specific molecule (called 4‐hydroxynonenal) [7].

It might specifically help tendons heal by causing tendon cells to make more receptors for growth signaling molecules. This, in turn, allows the tendon cells to grow and move during injury repair, speeding up the process [8, 9].

It can also reduce inflammation, which is probably involved in its effects on wounds, ulcers, and tissue protection [10, 11].

BPC 157 can also influence the activity of neurotransmitters like serotonin and dopamine. In turn, it might help with depression, seizures, pain, and may even promote gut health. More research is needed to understand exactly how it works in the brain [12, 13, 14, 3].

Lastly, it can increase the production of nitric oxide (NO), which lowers blood pressure and helps to reduce the effects of high potassium levels [15, 16].

Snapshot of BPC 157

Proponents

May promote healing and tissue regeneration

May reduce inflammation

May protect organs from toxins and damage

Skeptics

No published, peer-reviewed studies in humans

Unknown safety profile

May interact with other drugs and medications

Potential conflicts of interest for scientists doing the research

Benefits & Potential Uses of BPC 157

Animal and Cell Research (Lack of Evidence)

No clinical evidence supports the use of BPC 157 for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed should not be interpreted as supportive of any health benefit.

Peptides Side Effects

Peptides used to increase muscle mass come with numerous unwanted effects. While there are no data to say for sure whether BPC 157 will cause the same, some of the side effects associated with using peptides include [48, 49, 50, 51, 52]:

Kidney and liver toxicity

Unusual hunger and weight gain

Feeling hot or cold

Blood pressure changes (increase or decrease, depending on the peptide)

Heart problems like abnormal rhythms

Cancer

Fatigue and dizziness

Toxicity to fetuses

Additionally, many peptides are known to interact with medications. As such, it’s always best to ask a doctor before taking any peptide [48+].

Cancer Risk

Growing new blood vessels is useful when it comes to injury repair, but it can be dangerous when it comes to cancer. While no studies suggest that BPC 157 increases the risk of cancer, its ability to increase blood vessel growth may feed existing tumors and cause them to spread [53].

On the other hand, BPC 157 may actually be beneficial for reducing muscle wasting in cancer patients. Research is currently underway [54].

==========

BPC-157

BPC-157 seals and heals tissues, gums, and guts. BPC is a complex composition of 15 amino acids found in human gastric juice. It plays a significant role in healing various wounds, and researchers think it may help cure periodontitis. When it was administered to rats with periodontitis, their oral health improved enough to have scientists conclude that “BPC 157 may represent a new peptide candidate in the treatment of periodontal disease.” [xxv] It works on multiple pathways in the nucleus of the cell directing the silencing of genes that continue inflammation and promoting the genes that direct blood vessel, connective tissue, fascia, and nerve repair.

Leading edge biological dentists are having success with this very specific, revolutionary peptide protocol with BPC-157 for receding gums. Inform your holistic dentist about this protocol in advance. Dentists can reach out to the International Peptide Society for more information.

Here is the protocol:

• Dilute BPC-157 (5mg vial of peptide powder) with 1ml NaCI 0.9 (do not dilute with regular bacteriostatic water as that is too painful for gum injections). Note: NaCI will cause a suspension effect and you will see suspensions of particles with this reconstitution.

• Apply a drop of organic Peppermint essential oil to the gum/injection site to clean and provide a subtle anesthetization.

• Inject 0.25 ml in the receding gum area (4 injections total: two in upper gum tissues, two in the low area) using smaller dental needles.

• Repeat protocol in 3 weeks.

• Monitor. Repeat a third time if needed.

• Measure gum pockets before and after.

• Effect may be visible in 10 days.

BPC is also available in powder form (which is rare for a peptide), and this powder can be added to baking soda to make pastes (see below) and tooth-masks. It is also awesome added to oil pulling.

MAKE YOUR OWN ALKALINIZING TOOTHPASTE

Liquefy coconut oil in a double boiler and add in the other ingredients.

Mix together, pour into jars (a different jar for each person in the family),

and pop in the fridge to solidify.

Once solidified, it can be keep out of the fridge.

• 30 ml Coconut Oil

• 20 ml Baking Soda

• 20 drops Peppermint

• 10 drops Frankincense

• 10 drops Sweet Thyme

Fun and Effective Options:

5ml activated charcoal, or

6 capsules powdered BPC 157 peptide, or

4 capsules of powdered probiotics