Autosomal Dominant

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Autosomal dominant is one of many ways that a trait or disorder can be passed down through families.
In an autosomal dominant disease, if you get the abnormal gene from only one parent, you can get the disease. Often, one of the parents may also have the disease.
Inheriting a disease, condition, or trait depends on the type of chromosome affected (nonsex or sex chromosome). It also depends on whether the trait is dominant or recessive.
A single abnormal gene on one of the first 22 nonsex (autosomal) chromosomes from either parent can cause an autosomal disorder.
Dominant inheritance means an abnormal gene from one parent can cause disease. This happens even when the matching gene from the other parent is normal. The abnormal gene dominates.
This disease can also occur as a new condition in a child when neither parent has the abnormal gene.
A parent with an autosomal dominant condition has a 50% chance of having a child with the condition. This is true for each pregnancy.
It means that each child's risk for the disease does not depend on whether their sibling has the disease.
Children who do not inherit the abnormal gene will not develop or pass on the disease.
If someone is diagnosed with an autosomal dominant disease, their parents should also be tested for the abnormal gene.
Examples of autosomal dominant disorders include Marfan syndrome and neurofibromatosis type 1.
Inheritance - autosomal dominant; Genetics - autosomal dominant
Nussbaum RL, McInnes RR, Willard HF. Patterns of single-gene inheritance. In: Nussbaum RL, McInnes RR, Willard HF, eds. Thompson & Thompson Genetics in Medicine. 8th ed. Philadelphia, PA: Elsevier; 2016:chap 7.
Scott DA, Lee B. Patterns of genetic transmission. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed..Philadelphia, PA: Elsevier; 2020:chap 97.
Updated by: Anna C. Edens Hurst, MD, MS, Assistant Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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Autosomal Dominant. Autosomal Dominant. =. Autosomal dominance is a pattern of inheritance characteristic of some genetic diseases. "Autosomal" means that the gene in question is located on one of the numbered, or non-sex, chromosomes. "Dominant" means that a single copy of the disease-associated mutation is enough to cause the disease.
Autosomal Dominant. Autosomal dominance is a pattern of inheritance characteristic of some genetic diseases. "Autosomal" means that the gene in question is located on one of the numbered, or non-sex, chromosomes. "Dominant" means that a single copy of the disease-associated mutation is enough to cause the disease.
www.genome.gov/genetics-glossary/Autoso…
Where is the dominant gene located in autosomal dominant disorder?
Where is the dominant gene located in autosomal dominant disorder?
In an autosomal dominant disorder, the mutated gene is a dominant gene located on one of the nonsex chromosomes (autosomes).
www.mayoclinic.org/autosomal-dominant-in…
Is an abnormal gene dominant or recessive?
Is an abnormal gene dominant or recessive?
It also depends on whether the trait is dominant or recessive. A single abnormal gene on one of the first 22 nonsex (autosomal) chromosomes from either parent can cause an autosomal disorder. Dominant inheritance means an abnormal gene from one parent can cause disease.
medlineplus.gov/ency/article/002049.htm
Can you get autosomal dominant disease from only one parent?
Can you get autosomal dominant disease from only one parent?
In an autosomal dominant disease, if you get the abnormal gene from only one parent, you can get the disease. Often, one of the parents may also have the disease. Inheriting a disease, condition, or trait depends on the type of chromosome affected (nonsex or sex chromosome). It also depends on whether the trait is dominant or recessive.
medlineplus.gov/ency/article/002049.htm
https://www.genome.gov/genetics-glossary/Autosomal-Dominant
Перевести · Autosomal Dominant. Autosomal dominance is a pattern of inheritance characteristic of some genetic diseases. "Autosomal" means that the gene in question is …
https://medlineplus.gov/ency/article/002049.htm
Перевести · Autosomal dominant. Autosomal dominant is one of many ways that a trait or disorder can be passed down through families. In an autosomal dominant disease, if you get …
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Autosomal Dominant