Atopobium Vaginae 10

Atopobium Vaginae 10
This mini review describes the current scientific knowledge regarding the relevance of A. vaginae in the pathogenesis of BV and what should be considered when choosing a treatment. Role of A. vaginae in BV Atopobium vaginae is a newly discovered bacterium frequently found in women with BV [15].
May 20, 2025
Atopobium vaginae has been associated with vagina; discharge, increased vaginal pH and premature delivery [27]. The host responds to BV by producing pro-inflammatory cytokines like interleukins IL-1α, IL-1β and interferon γ-induced protein (IP-10) [32].
Role of A. vaginae in BV Atopobium vaginae is a newly discovered bacterium fre-quently found in women with BV [15]. The name Atopo-bium, meaning "strange living thing" in Greek, was pro-posed in 1992 [16] to reclassify three bacterial species formerly designated Lactobacillus minutus, Lactobacil-lus rimae and Streptococcus parvulus.
2 days ago
Atopobium is a genus of Actinomycetota, in the family Coriobacteriaceae. Atopobium species are anaerobic, Gram-positive rod-shaped or elliptical bacteria found as single elements or in pairs or short chains. Atopobium vaginae was discovered in 1999. [3] This is a facultative anaerobic bacteria, which form small colonies on blood agar at 37 °C is also positive for acid phosphatase. This ...
A. vaginae has been shown to play an important role in the pathophysiology of BV and is thought to be at least a partial cause of the known negative sequelae. The presence of A. vaginae in the BV-associated biofilms and its resistance to some antimicrobial substances has been described - this seems to have a major impact on treatment outcome.
Dec 3, 2025
Introduction In case of bacterial vaginosis (BV), lactobacilli are outnumbered by anaerobic bacteria. These bacteria have been described to form a polymicrobial biofilm ("clue cells") attached to the vaginal epithelium, possibly explaining the decreased sensitivity to antibiotic treatment and the frequent chronicity of BV. A better understanding of this biofilm may contribute to more ...
This kit detects Atopobium vaginae from DNA extracts. A 155 bp long fragment from the 16S rRNA gene is amplified with specific primers and detected with a FAM labeled hydrolysis probe (530 channel). For use on Roche LightCycler® systems.
View Atopobium vaginae Z242, titered (1 mL) 0804259 from our online collection of viruses, microorganisms, and other products for infectious disease diagnostic development.
The depletion of Lactobacillus spp. and the enrichment of anaerobes including Gardnerella vaginalis, Atopobium vaginae (Fannyhessea vaginal), Prevotella spp., Sneathia spp., and Megasphaera spp. promote the production of bioactive metabolites and bacteriocins that modulate the local immune response in a species-specific manner.
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Chao et al. [36] also noted that the presence of L. iners, Atopobium vaginae, and Gardnerella vaginalis was higher in HPV-positive women [as well as anaerobic bacteria (Bacteroides plebeius, Acinetobacter lwoffii, and Prevotella buccae)] than the HPV-negative women.
A high score of the pattern characterized by predominance of Atopobium vaginae, Gardnerella vaginalis and Lactobacillus iners with a minority of Lactobacillus crispatus had a higher CIN risk (OR 5.80, 95% CI 1.73‒19.4) and abundance of A. vaginae had a higher CIN risk (OR 6.63, 95% CI 1.61‒27.2).
Atopobium vaginae is defined as an anaerobic bacterium that is typically associated with bacterial vaginosis and is characterized by an increase in its presence alongside a decline in protective lactobacilli in the genital tract. AI generated definition based on: Microbial Biofilms, 2024
An update on the role of Atopobium vaginae in bacterial vaginosis: what to consider when choosing a treatment? A mini review July 2019 Archives of Gynecology and Obstetrics 300 (1)
Atopobium vaginae is defined as an anaerobic bacterium associated with bacterial vaginosis, which contributes to the overgrowth of microorganisms when the normal vaginal microbiota is disrupted.
PDF | Atopobium vaginae is an anaerobic Gram-positive bacterium. It is recognized as a causal agent of bacterial vaginosis onset and occasionally... | Find, read and cite all the research you need ...
MultiCode® Atopobium vaginae Primers - 00840487101384 Nucleic acid sequences, which, through specific binding or chemical reaction with substances in a specimen, are intended for use in a diagnostic application for identification and quantification of an individual chemical substance or ligand in biological specimens
Objectives Bacterial vaginosis (BV) is characterised by a change in the microbial composition of the vagina. The BV-associated organisms outnumber the health-associated Lactobacillus species and form a polymicrobial biofilm on the vaginal epithelium, possibly explaining the difficulties with antibiotic treatment. A better understanding of vaginal biofilm with emphasis on Atopobium vaginae and ...
Atopobium vaginae is defined as an organism that contributes to vaginal dysbiosis and has been previously under detected and underappreciated in the context of vaginal microbiota.
Role of A. vaginae in BV Atopobium vaginae is a newly discovered bacterium frequently found in women with BV [15]. The name Atopobium, meaning "strange living thing" in Greek, was proposed in 1992 [16] to reclassify three bacterial species formerly designated Lactobacillus minutus, Lactobacillus rimae and Streptococcus parvulus.
Background Previous studies have indicated that a recently described anaerobic bacterium, Atopobium vaginae is associated with bacterial vaginosis (BV). Thus far the four isolates of this fastidious micro-organism were found to be highly resistant to metronidazole and susceptible for clindamycin, two antibiotics preferred for the treatment of BV. Methods Nine strains of Atopobium vaginae, four ...
Summary Atopobium vaginae is an anaerobic Gram-positive bacterium. occasionally recognized associated as a causal to gynaecologic-obstetric agent of bacterial vaginosis complications onset and (including pelvic an inflammatory disease, endometritis, tubo-ovari-Additionally, abscesses and preterm reported. Th e s bacteraemia delivery cientific and technological invasive infections neonatal ...
Atopobium vaginae: Discover its history, role in bacterial vaginosis, diagnostic methods, treatment options, and impact on women's health.
One of the species often found incorporated in Gardnerella mediated biofilms is Atopobium vaginae. Interestingly, A. vaginae is very rarely found without the presence of Gardnerella. However, not much is known regarding the interactions between A. vaginae and Gardnerella species.
It is a bacterium that belongs to the genus Atopobium of the family Coriobacteriaceae. It is a facultative anaerobic cocobacillus, gram-positive, rod-shaped or elliptical bacteria found as individual elements, in pairs or short chains. It is usually isolated in 80% of women with bacterial vaginosis and is implicated in treatment failures.
Atopobium vaginae Updated : October 26, 2023 Epidemiology Structure and Classification Antigenic Types Pathogenesis Host Defenses Clinical Manifestations Diagnosis Control References The epidemiology of Atopobium vaginae is the study of the distribution and determinants of this bacterium in human populations.
Test Details
The unknown bacterium was readily distinguished from other Atopobium species by biochemical tests and electrophoretic analysis of whole-cell proteins. Based on phylogenetic and phenotypic evidence, it is proposed that the unknown bacterium be classified as Atopobium vaginae sp. nov. The type strain of Atopobium vaginae is CCUG 38953T.
Discover Atopobium vaginae, a Gram-positive bacterium linked to bacterial vaginosis (BV), affecting treatment and associated with complications.
Abstract Objective: The purpose of this study was to test the correlation of the amount of Atopobium vaginae with the most commonly used markers for bacterial vaginosis (BV). Materials and methods: We enrolled 103 nonpregnant and premenopausal women that were positive for BV by Amsel criteria and with a Nugent score higher than 3.
Material and Methods Literature research to the importance of Atopobium vaginae in BV and treatment options. Results Atopobium (A.) vaginae is an important component of the complex abnormal ...
ella vaginalis, Atopobium vaginae, and Mycoplasmahominis in vaginal fluid samples from women admitted for spontaneous preterm labor with intact membranes from July 2007 through July 2008. The primary outcome measure was the relationship between bacterial concentration at admission and preterm delivery, before 37 weeks of gestation. Sensitivity and specificity of molecular cutoff values and 95% ...
In a clinical study, LabCorp found excellent correlation of three BV markers (Atopobium vaginae, Bacterial vaginosis-associated bacterium [BVAB]-2, Megasphaera-1) to Nugent Gram stain score and Amsel clinical diagnosis.
However, BV is always associated with the presence of high loads of Atopobium vaginae and/or Gardnerella vaginalis [8, 9]. Our team previously showed that high vaginal concentrations of A. vaginae and/or G. vaginalis were associated with a significantly decreased interval between preterm labor and delivery in high-risk pregnancies [10, 11].
Notes: Atopobium vaginae is the correct name instead if this species is regarded as a separate species (i.e., if its nomenclatural type is not assigned to another species whose name is validly published, legitimate and not rejected and has priority) within a separate genus Atopobium. Atopobiumvaginae is the correct name instead if this species is regarded as a separate species (i.e., if its ...
is the official journal of the Italian Association of Clinical Microbiologists (AMCLI) and it is published by PAGEPress®, Pavia, Italy. All credits and honors to PKPfor their OJS.
Treatment of Atopobium vaginae (Bacterial Vaginosis) For bacterial vaginosis associated with Atopobium vaginae, metronidazole 500 mg orally twice daily for 7 days is the recommended first-line treatment, with clindamycin cream 2% intravaginally at bedtime for 7 days as an effective alternative, especially for metronidazole-resistant cases. 1, 2
After multivariate analysis, A. vaginae levels ≥10 (8) copies/mL remained significantly associated with delivery before 22 weeks of gestation (adjusted HR, 4.7; 95% CI, .2-17.6; P = .014). Conclusions: High vaginal loads of A. vaginae and G. vaginalis are associated with late miscarriage and prematurity in high-risk pregnancies.
Atopobium vaginae is a type of bacterium that lives in the vaginal microbiome. It doesn't always cause problems but can lead to bacterial vaginosis (BV).
Abstract. BackgroundWe investigated associations between Atopobium vaginae and bacterial vaginosis (BV) and the role that A. vaginae plays in recurrent BV
The scientific and technological progress allowed an accurate and rapid identification of Atopobium vaginae supporting diagnosis and clinic interventions. In this article, literature has been deeply examined to report the state-of-the-art on Atopobium vaginae, which might be useful in clinical scenarios.
Fannyhessea vaginae is a species of bacteria in the family Atopobiaceae, and the only species in the genus Fannyhessea. [4] It is a facultative anaerobic, Gram-positive rod-shaped or elliptical coccobacillus found as single elements or in pairs or short chains. [5] It is typically isolated from 80% of women with bacterial vaginosis and it is implicated in treatment failures. [6][7] Invasive ...
The molecular quantification of A. vaginae (DNA level, ⩾10 8 copies/mL) and G. vaginalis (DNA level, ⩾10 9 copies/mL) had the highest predictive value for the diagnosis of BV, with excellent sensitivity (95%), specificity (99%), and positive (95%) and negative (99%) predictive values; 25 (57%) of the samples demonstrating intermediate flora ...
Previous studies have indicated that a recently described anaerobic bacterium, Atopobium vaginae is associated with bacterial vaginosis (BV). Thus far the four isolates of this fastidious micro-organism were found to be highly resistant to ...
The BV test utilizes semiquantitative PCR analysis of the three most predictive marker organisms (Atopobium vaginae, BVAB-2, and Megasphaera -1) to generate a total score that correlates directly with the presence or absence of BV.
Moreover, there are specific associations between various vaginal microbes linked to BV (Mycoplasma hominis, Gardnerella vaginalis and Atopobium vaginae, alone or together) and preterm birth [49-52].
The genus Lactobacillus predominated in 7 out of the 10 women and Atopobium vaginae and Gardnerella vaginalis predominated in two others. Six of 10 women exhibited a significantly different profile of vulvar microbiota during menstruation.
Bacterial vaginosis (BV) is associated with a highly structured polymicrobial biofilm on the vaginal epithelium where Gardnerella species presumably play a pivotal role. Gardnerella vaginalis, Atopobium vaginae, and Prevotella bivia are vaginal ...
This case describes a 77-year-old woman with dysregulated type II diabetes, presenting with a prosthetic joint infection and bacteremia. Computed tomography (CT) of the pelvis and sacrum revealed manifest periprosthetic collections, suggestive of a septic arthritis with loosening of the hip prosthesis. Synovial fluid grew Fannyhessea vaginae, identified by matrix-assisted laser desorption ...
Gardnerella vaginalis, Atopobium vaginae, and Prevotella bivia are vaginal pathogens detected during the early stages of incident BV. Herein, we aimed to analyze the impact of A. vaginae and P. bivia on a pre-established G. vaginalis biofilm using a novel in vitro triple-species biofilm model.
Characterization of a novel Atopobium isolate from the human vagina: Description of Atopobium vaginae sp. nov.
Atopobium vaginae The discovery of A. vaginae 16S rDNA in vaginal fluid from women with BV perked interest in this species, which belongs to the Coriobacteriaceae family but had previously been classified as Lactobacillus [49,50].
Methods: Molecular methods were used to prospectively quantify Lactobacillus species, Gardnerella vaginalis, Atopobium vaginae, and Mycoplasma hominis in vaginal fluid samples from women admitted for spontaneous preterm labor with intact membranes from July 2007 through July 2008.
Here, we describe a rare case of bacteremia caused by F. vaginae in a pregnant woman with bacterial vaginosis and hypothesize that an ascending infection of F. vaginae in the vagina caused this woman's bacteremia. We also provide a review of previously published cases related to F. vaginae infections.
The Nugent score is derived from estimating the relative proportions of bacterial morphotypes to give a score between 0 and 10. A score of less than 4 is normal, 4 to 6 is intermediate, and greater than 6 is bacterial vaginosis.
It is a polymicrobial syndrome (dysbiosis) characterised by a profound change in the vaginal microbiota from a lactobacilli dominant state to one with high diversity and quantities of anaerobic bacteria including Gardnerella vaginalis, Atopobium vaginae, Mobiluncus spp, Prevotella spp, and other BV-associated bacteria (BVAB).
ABSTRACT We sequenced 16S rRNA genes from the vaginal swab contents of a postmenopausal woman with asymptomatic bacterial vaginosis (BV). Sequences from Atopobium vaginae were the most commonly detected. In a survey of 35 other postmenopausal women, this ...
High vaginal loads of A. vaginae and G. vaginalis are associated with late miscarriage and prematurity in high-risk pregnancies. A high vaginal load of A. vaginae (DNA level ≥10 8 copies/mL) identifies a population at high risk of preterm birth. Further studies that both screen for and then treat A. vaginae are needed. Clinical Trials ...
The BV test utilizes semiquantitative PCR analysis of the three most predictive marker organisms (Atopobium vaginae, BVAB-2, and Megasphaera -1) to generate a total score that correlates directly with the presence or absence of BV.
Atopobium vaginae is an anaerobic gram-positive organism associated with genitourinary infections. Bacteraemia is rare, with only two cases reported in the literature. This case describes an 18-year-old type 1 diabetic, presenting with sepsis and haemoptysis, ...
Bacterial Vaginosis (BV) is usually caused by Gardnerella vaginalis, Atopobium vaginae (a gram positive rod; facultative anaerobe), Mycoplasma hominis, Ureaplasma urealyticum and various anaerobic bacteria including Mobiluncus sp., and Prevotella sp., Prevotella sp., Porphyromonas sp., Bacteroides sp., Peptostreptococcus sp., and Fusobacterium sp.
Vaginal microbiome studies provide information which may change the way we define vaginal flora. Normal flora appears dominated by one or two species of Lactobacillus. Significant numbers of healthy women lack appreciable numbers of vaginal ...
High vaginal concentrations of Atopobium vaginae and Gardnerella vaginalis in women undergoing preterm labor.
Sneathia spp., Atopobium vaginae, BVAB1 and Ureaplasma urealyticum were measured in 250 women from the PID Evaluation and Clinical Health (PEACH) study. Relative risk (RR) and 95% confidence intervals (CI) were calculated adjusting for chlamydia and gonorrhea. Principal component analysis was used to adjust for population stratification.
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