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mephedrone.
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The Story of Mephedrone, the Party Drug That Boomed and Went Bust
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So where did it come from and how did it fall so out of favor? The active agent in mephedrone is a form of cathinone, a substance that occurs naturally in khat, the mildly stimulative root chewed all over the Horn of Africa. The exponentially stronger 'substituted cathinone' molecule in mephedrone was re-synthesized in by the legendary Israeli underground chemist Dr. This quantity was enough to produce around million ecstasy pills, so its seizure had huge reverberations throughout the international drugs market. In , the purity of ecstasy sold in the UK plummeted from roughly 60 percent to 22 percent. At the same time, the quality of cocaine was running at historical lows. This pretty much set the scene for mephedrone—a drug described by most users as feeling like a mixture of MDMA and coke, and which people could order cheaply and easily off the internet because it was completely legal, sold as 'plant food' on sites with names like legalchems. No surprises, then, that people went nuts for it. It made your body feel crazy and tingly, and gave you these really intense rushes of energy. And obviously made you horny as fuck. During the period Andre describes, it seemed like every club, house party, and festival in Britain was awash with the stuff. This presented an opportunity for amateur dealers. It started out as just other students in London, but soon it was guys coming in from the suburbs or Kent for a night out. It paid my rent for a year, and I went on a bunch of holidays, always paying cash. The explosion of this new legal high had various knock-on effects, most noticeably the unprecedented drop in deaths from cocaine use. Neil Woods, who worked as an undercover drugs cop for 14 years, tracked the phenomenon closely. The only year since the Misuse of Drugs Act that cocaine deaths have actually fallen is the year that mephedrone was at its most popular, ,' he says. It turned out this was a joke someone had posted on the message board of a website called mephedrone. Then came a huge outcry over the deaths of two teenagers, reportedly from mephedrone—who turned out to have actually been taking the heroin substitute methadone. The drug was banned before proper laboratory experimentation could be done, but there are obvious repercussions to your health—notably how terrible you look and feel after doing it for any period of time. Even Josh the dealer wrestled with how he saw some people reacting to his product. Some people had to drop out of uni or repeat a year because of it. That was the dark side. By April , looking to appear 'tough on drugs' before the general election, the Labour government banned mephedrone. Several members of the Advisory Council on the Misuse of Drugs resigned at this obvious knee jerk reaction to tabloid reporting. But, in fairness, the ban sort of worked—people did largely stop snorting m-cat. The ban was also great news for dealers. Josh recalls: 'It was only when it became illegal that things got really good. We were reading The Sun and all the chat online. We knew it was going to become illegal, so we stocked up. Josh is clear that he was only ever running a small operation for students. But, as Neil Woods notes, the effect on the criminal underworld was serious. With the ban, it was organized crime groups that took the benefit—a huge new market was simply gifted to them on a plate. The other effect of the mephedrone ban was a massive intensification of the cat-and-mouse game that underground scientists had been playing with the authorities for years, making minute tweaks to chemical compounds before law enforcement had a chance to ban them. This led to the explosion of new research chemicals or 'bath salts,' as the American press dubbed them , highly unpredictable chemicals marketed as legal analogues of conventional drugs: 'Gocaine,' for instance, or 'China White. The move was described by former Chief Government Drugs Advisor David Nutt as 'arguably the worst piece of legislation in living memory. Once again, control of all these newly banned substances was handed to organized criminals on a platter. Henry Fisher from the drug-policy think tank VolteFace is clear: 'The demand for legal highs has been displaced to the illegal market… into the hands of street dealers. The Psychoactive Substances Act was inevitable, but ridiculous—ban imaginary drugs, as if banning tangible ones had ever made a difference. So where does that leave mephedrone now? I ask Denholm why mephedrone in particular is so popular for chemsex. Maybe it seems like a remedy to what lots of gay men feel—a kind of unlovability, being brought up with constant background homophobia. Another chemsex partier, Danny, puts it more bluntly: 'Mephedrone? All I know is it just makes you want to fuck everything. And in that one phrase, maybe he has summed up not only the appeal and history of mephedrone, but also the response of lawmakers to the entire issue of 'legal highs'—fucking everything up while trying to be helpful. Jan 17 , pm.
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Symptoms of Being High on Mephedrone
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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Mephedrone belongs to a group known as the substituted cathinone , which are derivatives of the active ingredient in the khat plant Catha edulluis. Mephedrone was first synthesized in , but did not become widely known until it was rediscovered in By , it was reported to be available for sale on the internet, by law enforcement agencies had become aware of the compound, and by it had been reported in most of Europe, becoming particularly prevalent in the United Kingdom. It comes in the form of tablets or a powder, which users can swallow, snort, inject or insert rectally, producing effects which are somewhat similar to those of MDMA , amphetamine , and cocaine. It is reported to produce a mixture of classic stimulant and entactogenic effects effects reminiscent of cocaine and MDMA. Mephedrone, or 4-methylmethcathinone, is a synthetic molecule of the cathinone family. Amphetamines and cathinones are alpha-methylated phenethylamines, cathinones contain an additional carbonyl group at R 1. Given its chemical structure, mephedrone is likely to act as a releasing agent and a reuptake inhibitor for monoamine neurotransmitters such as dopamine , serotonin and noradrenaline. Several articles published near the end of examined the effects of mephedrone in the brains of rats, as well as examining the reinforcing potential of mephedrone. Dopamine and serotonin were collected using microdialysis, and increases in dopamine and serotonin were measured. They reached their peak concentrations at 40 minutes and 20 minutes and returned to baseline by minutes after injection. Analysis of the ratio for dopamine and serotonin indicated mephedrone was preferentially a serotonin releaser , with a ratio of 1. Additionally, half-lives for the decrease in dopamine and serotonin were calculated and found to have decay rates of These findings show mephedrone induces a massive increase in both dopamine and serotonin , combined with rapid clearance. This increase in neurotransmitters provides an explanation for the euphoric and stimulating subjective effects induced by this experience. The rapid rise and subsequent fall of dopamine levels could also explain some of the addictive properties of mephedrone display in some users. Disclaimer: The effects listed below are cited from the Subjective Effect Index SEI , which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:. Almost nothing is known about the long-term effects of mephedrone due to its short history of its use. In , unconfirmed reports speculated about the role mephedrone has played in the deaths of several young people in the UK. By July , mephedrone had been alleged to be involved in 52 fatalities in the UK, but detected in only 38 of these cases. Of the nine that coroners had finished investigating, two were caused directly by mephedrone. Despite similarities to known neurotoxins such as methamphetamine and other cathinone derivatives, mephedrone does not appear to produce neurotoxic effects in the dopamine system of mice. It is strongly recommended that one use harm reduction practices when using this drug. As with other stimulants , the chronic use of mephedrone can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Tolerance to many of the effects of mephedrone develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. Mephedrone presents cross-tolerance with all dopaminergic stimulants , meaning that after the consumption of mephedrone all stimulants will have a reduced effect. Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations although it cannot be guaranteed to include all of them. Independent research e. Google , DuckDuckGo should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit. Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated. Summary sheet: Mephedrone Mephedrone. Physical effects. Cognitive effects. After effects. July Archived from the original PDF on Retrieved BBC News. Forensic Science International 1 : e62—e PMID Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5 2 , Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95 4 , Die Presse. August 22, Retrieved December 27, State Food and Drug Administration. Archived from the original on 15 August Croatian Ministry of Health and Social Welfare. Estonian Ministry of Social Affairs. Archived from the original on September 21, City Magazine. Retrieved December 10, Bundesanzeiger Verlag. April 13, Isle of Man Today. February 25, Archived from the original on February 28, Irish Department of Health and Children. Archived from the original on February 21, Ministero della Salute. BBC Newsbeat. Retrieved December 26, United Nations Office on Drugs and Crime. Archived from the original on February 10, Archived from the original PDF on February 10, Misuse of Drugs Act S. London: The Stationery Office Limited. Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Community Network YouTube Good vibes. Summary sheet: Mephedrone.
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