Anti-Cancer Benefit Of Xao Tam Phan Paramignya Trimera Methanol Root Extract On Human Breast Cancer

Xao tam phan (Paramignya trimera (Oliv.) Guillaum) is often a Vietnamese traditionally medicinal plant used in the management of numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. This research aimed to investigate the effects of 5 various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The results indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the best antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (apart from total flavonoids) and antioxidant capacity, in comparison with conventional and ultrasound-assisted extractions. These data reveal that the use of methanol and microwave-assisted extraction are suggested for extraction of biologically active phytochemicals from P. trimera root for application in the nutraceutical and/or pharmaceutical industries.

Drying methods, solvents and extraction methods greatly modify the phytochemical compounds and biological activity from plant materials. The aims with this study would determine the effects of numerous drying methods, various solvents and extraction methods on the phytochemical compounds and antioxidant capacity from Xao tam phan (Paramignya trimera) root extracted from Vietnam. The outcome showed that microwave drying was a powerful method in elimination of water with regards to shortest drying time, lowest energy consumption as well as retention of phytochemical compounds and antioxidant capacity from the P. trimera root while methanol and microwave-assisted extraction were the very best solvent and way of greatest extraction from the phytochemical compounds and antioxidant capacity from your P. trimera root. The findings using this study allow retaining the best numbers of phytochemical compounds and antioxidant capacity in the P. trimera root for potential application in the nutraceutical industry.

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