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Amphetamine is a powerful stimulator of the central nervous system. It is used to treat some medical conditions, but it is also highly addictive, with a history of abuse. Stimulants such as amphetamine Adderall and methylphenidate Ritalin and Concerta are used to treat attention deficit hyperactivity disorder ADHD. Used under prescription, stimulants can be safe and effective. Amphetamine sulphate, or speed, is also used for recreational and non-medical purposes. It can lead to euphoria, and it suppresses the appetite, which can lead to weight loss. Used outside the medical context, stimulants can have severe adverse effects. Amphetamine activates receptors in the brain and increases the activity of a number of neurotransmitters, especially norepinephrine and dopamine. Dopamine is associated with pleasure, movement, and attention. Amphetamine has been trialed for a wide variety of conditions. Now, it is mainly used to treat ADHD, and, rarely, depression. In the past, it has been used to treat narcolepsy and to help with weight loss, but this is less common now. ADHD is characterized by hyperactivity, irritability, mood instability, attention difficulties, lack of organization, and impulsive behaviors. Amphetamines reverse some of these symptoms and have been shown to improve brain development and nerve growth in children with ADHD. Long-term treatment with amphetamine-based medication in children appears to prevent unwanted changes in brain function and structure. Scientists carrying out a review of 20 studies concluded that stimulants are probably helpful for people with ADHD. They found that the brain structures of people who took stimulants for ADHD were more likely to resemble the brain structures of people without the condition than to resemble those with ADHD who did not use the drugs. A review published in Cochrane in suggested that adults with ADHD might benefit from short-term use of amphetamines, but that they were unlikely to persist with the treatment because of adverse effects. Those who use mixed amphetamine salts, however, were more likely to continue with the treatment. A person with narcolepsy will experience excessive daytime sleepiness and irresistible sleep episodes, called 'sleep attacks. In a person with this condition, strong emotions can trigger a sudden loss of muscle tone, or cataplexy, which causes a person to collapse and possibly fall down. It also involves frequent and unexpected bouts of sleep. Due to concerns over their side effects, however, amphetamines are increasingly being replaced by modafinil, a medication that promotes wakefulness. Under the name Benzedrine, amphetamines were first used to treat obesity in the s, due to their appetite-suppressing capabilities. In the s, reports of malnutrition , psychosis, and depression on withdrawal caused doctors to stop prescribing amphetamines for weight loss. Currently, medical professionals do not recommend using amphetamines and their derivatives to help reduce obesity. They proposed a 6-month use of the drug to help people who have not responded to other treatment to improve their diet and increase exercise levels. This, they say, could help curb obesity and related complications, such as diabetes and cardiovascular disease. From the s, amphetamine was used to treat affective disorders, obsessive-compulsive disorder OCD , and schizophrenia. However, in the s and s, amid growing concern about its adverse effects, it was replaced by newly available antidepressants. In rare cases, amphetamines are used alongside standard antidepressants to treat some types of depression that do not respond to other treatments, especially in people who also experience fatigue and apathy. In a study that followed 65 patients taking amphetamines alongside normal medication, 38 'showed significant improvement, in particular with respect to energy, mood, and psychomotor activity. Physical side effects include :. People who follow the prescribed, therapeutic dose are unlikely to experience severe adverse effects. There have been fears that long-term use of amphetamines for ADHD could affect brain development, prevent physical growth, and increase the risk of drug abuse later in life. However, animal studies have suggested that this is unlikely. There is evidence that amphetamine use to treat ADHD could slow growth in children. Minor effects on the cardiovascular system, including a rise in heart rate and blood pressure , may have long-term effects. However, some studies show that any reduction in growth speed may be caught up by a 'growth rebound' once the drug has stopped being taken. Amphetamine is used as a recreational drug. People take it to boost libido, increase wakefulness, improve cognitive control, enhance sociability, and induce euphoria. When amphetamines are used at higher doses and through routes that are not prescribed by a doctor, they can have severe adverse effects. Dopamine levels in the brain can rise quickly, and to a great extent. People who crush and inject a tablet may have blockages in their small blood vessels, as some of the components do not break down. Other street drugs that are based on the structure of amphetamine include methamphetamine, cathinone, ephedrine, MDMA ecstasy , and 2,5-Dimethoxymethylamphetamine DOM. These drugs can have a wide variety of overlapping effects that broadly fit into three categories:. These drugs are made illegally, and there is no control over their contents. For this reason, a person can easily consume something they do not expect to consume. This can be hazardous, and, in some cases, fatal. Contraindications for amphetamines include :. Children and teenagers who have a heart problem may be at risk of sudden death if they use amphetamines. Anyone who is taking supplements should make sure their doctor knows about this, if they may be prescribed amphetamines. The herbal supplement, St. Methylphenidate is a stimulant drug that doctors prescribe to treat attention deficit hyperactivity disorder ADHD and narcolepsy. Learn about how it…. Both drugs are similar, but there are some differences in how they…. Uses and risks of amphetamine Medically reviewed by Alan Carter, Pharm. Medical uses Risks As a narcotic Contraindications Amphetamine is a powerful stimulator of the central nervous system. Fast facts about amphetamines Amphetamines are central nervous system CNS stimulants. They are used to treat ADHD and narcolepsy. Adverse effects include restlessness, acne , and blurred vision. Rarer side effects include seizures, heart problems, and psychosis. Amphetamines are used for recreational purposes. They are addictive. Medical uses. Share on Pinterest Amphetamines come in different forms. They are used to treat ADHD and as a recreational drug. As a narcotic. Medically reviewed by Alan Carter, Pharm. Latest news High protein foods may put heart health at risk. Why do some primates live in pairs? How your morning alarm may set the tone of your day. How menopause affects blood vessel health. What to know about executive function disorder. Vyvanse vs. Adderall: What to know. Concerta vs. Vyvanse for ADHD. Related Coverage. Everything you need to know about methylphenidate Methylphenidate is a stimulant drug that doctors prescribe to treat attention deficit hyperactivity disorder ADHD and narcolepsy. How are Dexedrine and Adderall different?
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Amphetamine is a central nervous system stimulant that affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control. Evekeo is sometimes used to treat obesity in people who have not lost weight with diets or other treatments. Amphetamine may be habit-forming, and this medicine is a drug of abuse. Tell your doctor if you have had problems with drug or alcohol abuse. Stimulants have caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect. Do not use amphetamine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Amphetamine may cause new or worsening psychosis unusual thoughts or behavior , especially if you have a history of depression, mental illness, or bipolar disorder. You may have blood circulation problems that can cause numbness, pain, or discoloration in your fingers or toes. Call your doctor right away if you have: signs of heart problems --chest pain, feeling light-headed or short of breath; signs of psychosis --paranoia, aggression, new behavior problems, seeing or hearing things that are not real; signs of circulation problems --unexplained wounds on your fingers or toes. Do not use amphetamine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Some medicines can interact with amphetamine and cause a serious condition called serotonin syndrome. Ask your doctor before making any changes in how or when you take your medications. Stimulants have caused stroke, heart attack, and sudden death in certain people. Tell your doctor if you have:. To make sure amphetamine is safe for you, tell your doctor if you or anyone in your family has ever had:. Taking this medicine during pregnancy can cause premature birth, low birth weight, or withdrawal symptoms in the newborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea. Amphetamine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Avoid drinking fruit juices or taking vitamin C at the same time you take amphetamine. These can make your body absorb less of the medicine. Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Ask your doctor before using a stomach acid medicine including Alka-Seltzer or sodium bicarbonate. Some of these medicines can change the way your body absorbs amphetamine, and may increase side effects. Many drugs can affect amphetamine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Amphetamine may be habit-forming. Never share amphetamine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law. If your doctor changes your brand, strength, or type of stimulant medicine, your dosage needs may change. Use only the brand of this medicine your doctor has prescribed. Shake the oral suspension liquid before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen spoon. While using this medicine, your doctor will need to check your progress at regular visits. Tell any doctor who treats you that you are using this medicine. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. Keep track of your medicine. Amphetamine is a drug of abuse and you should be aware if anyone is using it improperly or without a prescription. Seek emergency medical attention or call the Poison Help line at An overdose of amphetamine could be fatal. Overdose symptoms may include restlessness, tremor, muscle twitches, rapid breathing, hostility, violence, panic, muscle pain or weakness, and dark colored urine. These symptoms may be followed by depression and tiredness. Overdose may also cause seizure or coma. Take the missed dose as soon as you remember, but not late in the day. Skip the missed dose if it is almost evening. Do not take two doses at one time. Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Neither Everyday Health nor its licensors endorse drugs, diagnose patients or recommend therapy. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. What Is Amphetamine? Amphetamine Side Effects. Amphetamine Interactions. Amphetamine Dosage. Copyright Cerner Multum, Inc. Read Next Amphetamine Reviews.
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