Амантадин — Википедия

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Amantadine trade name Symmetrel , by Endo Pharmaceuticals is a drug that has U. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug. It is the organic compound 1-adamantylamine or 1-aminoadamantane , meaning it consists of an adamantane backbone that has an amino group substituted at one of the four methyne positions. Rimantadine is a closely related derivative of adamantane with similar biological properties. Apart from medical uses, this compound is useful as a building block in organic synthesis, allowing the insertion of an adamantyl group. According to the U. Additionally, its effectiveness as an antiparkinsonian drug is undetermined, with a Cochrane Review concluding that there was insufficient evidence in support of or against its efficacy and safety. An extended release formulation is used to treat dyskinesia , a side effect of levodopa which is taken by people who have Parkinsons. Amantadine is no longer recommended for treatment of influenza A infection. Amantadine also seems to have moderate effects on multiple sclerosis MS related fatigue. The usefulness of amantadine as an anti-parkinsonian drug is somewhat limited by the need to screen patients for a history of seizures and psychiatric symptoms. Rare cases of severe skin rashes, such as Stevens-Johnson syndrome , \\\\\\\\\\\\\\[10\\\\\\\\\\\\\\] and of suicidal ideation have also been reported in patients treated with amantadine. Acidification of the interior results in disassociation of ribonucleoproteins, and the initiation of viral replication. Amantadine and rimantadine function in a mechanistically identical fashion in entering the barrel of the tetrameric M2 channel, and blocking pore function i. Resistance to the drug class is a consequence of mutations to the pore-lining residues of the channel, leading to the inability of the sterically bulky adamantane ring that both amantadine and rimantadine share, in entering in their usual way, into the channel. Influenza B strains possess a structurally distinct M2 channels with channel-facing side chains that fully obstruct the channel vis-a-vis binding of adamantine-class channel inhibitors, while still allowing proton flow and channel function to occur; this constriction in the channels is responsible for the ineffectiveness of this drug and rimantadine towards all circulating Influenza B strains. Amantadine is a weak antagonist of the NMDA-type glutamate receptor , increases dopamine release , and blocks dopamine reuptake. It appears to be a weak NMDA receptor antagonist \\\\\\\\\\\\\\[18\\\\\\\\\\\\\\] \\\\\\\\\\\\\\[19\\\\\\\\\\\\\\] as well as an anticholinergic , specifically a nicotinic alpha-7 antagonist like the similar pharmaceutical memantine. Amantadine was approved by the U. Food and Drug Administration in October as a prophylactic agent against Asian influenza, and eventually received approval for the treatment of influenzavirus A \\\\\\\\\\\\\\[21\\\\\\\\\\\\\\] \\\\\\\\\\\\\\[22\\\\\\\\\\\\\\] \\\\\\\\\\\\\\[23\\\\\\\\\\\\\\] \\\\\\\\\\\\\\[24\\\\\\\\\\\\\\] in adults. In , the U. In , Chinese poultry farmers were reported to have used amantadine to protect birds against avian influenza. Chickens in China have received an estimated 2. If amantadine-resistant strains of the virus spread, the drugs of choice in an avian flu outbreak will probably be restricted to the scarcer and costlier oseltamivir and zanamivir , which work by a different mechanism and are less likely to trigger resistance. On September 23, , the US Food and Drug Administration announced the recall of Dingo Chip Twists 'Chicken in the Middle' dog treats because the product has the potential to be contaminated with amantadine. From Wikipedia, the free encyclopedia. C Risk not ruled out. S4 Prescription only CA: This section relies too much on references to primary sources. Please improve this section by adding secondary or tertiary sources. June Learn how and when to remove this template message. Retrieved 24 February Clarke, Carl E, ed. Cochrane Database of Systematic Reviews. Centers for Disease Control and Prevention. Archived from the original on 3 May Journal of Infectious Diseases. The Cochrane database of systematic reviews. Canadian Journal of Psychiatry. Austria-Codex in German 62nd ed. European Journal of Neuroscience. Science and Corporate Strategy: The New York Times. Retrieved May 19, Amantadine Budipine Methylxanthines e. Genetic structure Transmission and infection Global spread Vaccine clinical trials Human mortality Social impact Pandemic preparation. Live attenuated influenza vaccine Fluzone Pandemrix. Canine Feline Equine Australian outbreak Swine. Interferon alfa 2b Peginterferon alfa-2a. Adapromine Amantadine Bromantane Memantine Rimantadine. Oxiracetam Phenylpiracetam Phenylpiracetam hydrazide. Ionotropic glutamate receptor modulators. Neomycin Spermidine Spermine ; Other positive allosteric modulators: Selective norepinephrine reuptake inhibitors: Amoxapine Maprotiline Mianserin Oxaprotiline Setiptiline. Selective serotonin reuptake inhibitors: A Amoxapine Antihistamines e. Nicotinic acetylcholine receptor modulators. Retrieved from ' https: CS1 German-language sources de Template: Views Read Edit View history. In other projects Wikimedia Commons. This page was last edited on 15 November , at By using this site, you agree to the Terms of Use and Privacy Policy. Minimal mostly to acetyl metabolites \\\\\\\\\\\\\\[1\\\\\\\\\\\\\\]. DA precursors Levodopa Melevodopa. Pandemics 'Spanish flu' 'swine flu'. Interferon Interferon alfa 2b Peginterferon alfa-2a.

Амантадин — Википедия

АМАНТАДИН, действующее вещество

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Amantadine

Амантадин (Amantadine)

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Амантадин (Amantadine)

Amantadine

Амантадин (Amantadine)

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Амантадин (Amantadine)

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Амантадин (Amantadine)

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