Als Scans
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Als Scans
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Understanding ALS
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Ask the Doc: Q & A with Edward Kasarskis, M.D., Ph.D.
If a person has muscle twitches a lot, or even daily, could it be the beginning of ALS? What do fasciculations or muscle twitching mean?
Ask the Doc: Q & A with Edward Kasarskis, M.D., Ph.D.
How long does a diagnosis take? Should I go to my general practitioner? What tests are needed to make the diagnosis?
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ALS is a disease that typically involves a gradual onset. The initial symptoms of ALS can be quite varied. One person may have trouble grasping a pen or lifting a coffee cup, while another may experience a change in vocal pitch when speaking.
The progression rate of ALS can be quite variable, as well. Although the mean survival time with ALS is three to five years, some people live five years, 10 years or even longer.
Symptoms can begin in the muscles that control speech and swallowing or in the hands, arms, legs or feet. Not all people with ALS experience the same symptoms or the same sequences or patterns of progression. However, progressive muscle weakness and paralysis are universally experienced.
A gradual onset of progressive muscle weakness – which is generally painless – is the most common initial symptom in ALS. Other early symptoms vary but can include tripping, dropping things, abnormal fatigue of the arms and/or legs, slurred speech, muscle cramps and twitches and uncontrollable periods of laughing or crying.
When the breathing muscles become affected, people with the disease will ultimately need permanent ventilatory support to assist with breathing.
Since ALS attacks only motor neurons, the senses of sight, touch, hearing, taste and smell aren’t affected. For many people, muscles of the eyes and bladder generally are generally not affected.
ALS is a difficult disease to diagnose. There is no one test or procedure to ultimately establish the diagnosis of ALS. It’s only through a clinical examination and series of diagnostic tests, often ruling out other diseases that mimic ALS, that a diagnosis can be established.
A comprehensive diagnostic workup includes most, if not all, of the following procedures:
These tests are done at the discretion of the physician, usually based on the results of other diagnostic tests and the physical examination. Several diseases have some of the same symptoms as ALS, and most of those conditions are treatable. Our ThinkALS tool was designed to help physicians diagnose the disease as early as possible.
The ALS Association recommends that a person diagnosed with ALS seek a second opinion from an ALS expert – someone who diagnoses and treats many ALS patients and has training in this medical specialty.
The ALS Association maintains a list of recognized experts in the field of ALS. See The ALS Association Certified Centers and ALS Clinics page for more information and/or contact your local ALS Association chapter or the National Office.
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Home » Blog » Understanding ALS » MRI Scans and Diagnosing ALS
Magnetic resonance imaging (MRI) is used to identify and diagnose a wide range of health conditions. Taking images of the internal body structure using a series of magnets and radio waves, it is often used in the diagnosis of ALS to help medical professionals exclude the possibility of other potential conditions . However, research has suggested that MRI scans may well be used as a more focused diagnostic tool in the near future.
Diagnosing a disease such as ALS is generally not just a simple case of listing the symptoms. This may well be a starting point for doctors, but further investigation will be needed before a full and accurate diagnosis is made.
If a physician suspects a condition such as ALS , the first thing that needs to be done is to have the individual assessed by a neurologist. They will start with a physical exam, which will look at any symptoms that are present. They will also examine the patient’s personal and family medical history.
Initial symptoms of ALS might include slurred speech, muscle twitching, muscle weakness and issues such as difficulty walking or problems with balance. During the diagnosis, a number of tests can be carried out. Many of these are used to exclude other potential conditions and are not signifiers of ALS being present in itself.
One test that is routinely carried out in the diagnostic process for ALS is an MRI scan. Here we take a closer look at this particular process, what it involves and how MRI scans may have a greater role to play in the future.
Magnetic resonance imaging uses a combination of radio waves and a magnetic field to produce detailed pictures of the internal body.
MRI scans are used to exclude the possibility of other conditions being the cause of the patient’s symptoms.
However, there are studies that suggest it can be used to diagnose ALS by identifying specific biomarkers that are related to the disease.
The evidence so far is limited and more research is needed, but the initial findings offer the potential for an exciting new development in the process of diagnosing ALS.
There are a number of different types of
MRI scan that may be used to help with the detection and diagnosis of ALS. The
main ones used include:
Whilst MRI equipment can look quite frightening, it’s a non-invasive technique that is performed safely on individuals every day in hospitals or radiology centers across the USA and throughout the world. .
MRI scans are useful for excluding the potential of other diseases but cannot be used to definitively diagnose ALS. Not yet anyway.
There have been few studies undertaken in this area and more research needs to be done, but the presence of certain biomarkers may allow physicians in the future to make a quicker and more authoritative diagnosis.
In the research that has been carried out to date, the low number of subjects and differences in presentation of the disease for individuals has led to variable results.
Larger numbers of participants and more longitudinal studies are needed if we are to fully understand what MRI scans are detecting and whether they can be used to more directly diagnose amyotrophic lateral sclerosis.
What is the ALS Functional Rating Scale (ALSFRS)?
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