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Ultra-rapid opiate detoxification using dexmedetomidine under general anesthesia

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Background: In this study, ultra-rapid detoxification using dexmedetomidine under general anesthesia GA has been evaluated in preventing the withdrawal symptoms in patients addicted to opioids. Patient satisfaction was assessed using point verbal rating scale. Results: Hemodynamic data showed that there were statistically significant increases in heart rate and systolic blood pressure during anesthesia in control group. Control group had significantly higher OOWS score on the following 3 days than the dexmedetomidine group, with no significant changes between the two groups from the fourth day till the sixth day except for muscle twitches in the control group on the sixth day Cd6. Control group had significantly higher SOWS score on the following 4 days than the dexmedetomidine group, with no significant changes between the two groups on the fifth and sixth days except for yawning, nausea, and muscle twitches in control group on the fifth and sixth days Cd5, Cd6. Patient satisfaction was significantly greater in dexmedetomidine group than in control group. Conclusions: Dexmedetomidine had shown to decrease markedly the withdrawal symptoms when used during ultra-rapid opiate detoxification under GA, and the patients in this group were more satisfied. Can J Anaesth. Reference Manual, Policy No. Medical Policy, Growing implications for primary care. Arch Intern Med. Eur J Pharmacol. Arain SR, Ebert TJ: The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation. Anesth Analg. Am J Alcohol Abuse. J Neurosci. Hensel M, Kox WJ: Safety, efficacy, and long-term results of a modified version of rapid opiate detoxification under general anaesthesia: A prospective study in methadone, heroin, codeine and morphine addicts. Acta Anaesthesiol Scand. Finkel JC, El Refai A: The use of dexmedetomidine to facilitate opioid and benzodiazepine detoxification in an infant. Drug Alcohol Depend. J Addict Dis. In Edwards G, Arif A eds. Geneva: World Health Organization, J Clin Anesth. Eur Arch Psychiatry Clin Neurosci. Shukry M, Cain J: Dexmedetomidine prevents and treats agitation, delirium, and withdrawal. Ashton H: Benzodiazepine withdrawal: Outcome in 50 patients. Br J Addict. Milne B: Alpha-2 agonists and anaesthesia. Leslie J: Advances in anesthetic pharmacology. Audio-Dig Anesthesiol. Maccioli GA: Dexmedetomidine to facilitate drug withdrawal. Omran, MD, S. Hakim, MD, and W. Mansour, MD. Journal of Opioid Management , vol. Issue Vol. Old JOM header. Subscription Login to access subscriber-only resources. Make a Submission Make a Submission. Most Read Articles The relationship between opioid and sugar intake: Review of evidence and clinical applications. Tramadol: Does it have a role in cancer pain management? Tramadol-associated mania: A case report.

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