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Last Update Posted : February 22, 2019
National Institute on Deafness and Other Communication Disorders (NIDCD)
Information provided by (Responsible Party):
Margaretha L. Casselbrant, University of Pittsburgh
This study is to measure over time (from 3 years until 13 years of age) Eustachian tube function (the way the Eustachian tube works) and facial growth in groups of children with two types of middle-ear disease and with little past middle-ear disease. These measures will be used to determine if facial growth is related to improved Eustachian tube function, to see if the better function explains why young children who have middle-ear disease outgrow it as they get older, and to determine if these measures are different for the children in the three groups defined by disease history.
The existing literature documents an important role for the Eustachian tube (ET) in the pathogenesis and/or persistence of otitis media (OM). Cross-sectional studies report a lower prevalence of OM in older children, a better ET pressure-regulating function in older children and age-related differences in ET form, length and width, and the vector orientation of the paratubal musculature. These growth-related changes in ET structural relationships are demonstrably predictive of increasingly more efficient ET function (ETF) and, because the ET and paratubal musculature are intimately related to the cranial base, the vector orientation of the ET system can be reconstructed from osteological or radiographic data. Together, these observations suggest that measurable, age-related changes in ET-paratubal muscle vector relationships are reflected in more efficient ETF and, by consequence, a decreased OM risk. The overall goal of the proposed longitudinal study is to evaluate the validity of this hypothesis.
MedlinePlus related topics:
Ear Infections
history of chronic effusion (3 months if both ears, 6 months if one ear, or 3 episodes of effusion each lasting for 2 months or longer)
recurrent acute otitis media (3 episodes in 6 months or 4 episodes in 1 year)
no history of significant otitis media (i.e., does not meet criteria for chronic OME or recurrent AOM)
Eustachian tube function is tested yearly from age 3 years through age 7 years
cross-correlations of anthropometric variables obtained by facial measurements, with growth over 5 years
measurements obtained on cephalometric x-rays
Eustachian tube function tested yearly through 13 years of age
cells obtained from buccal brushing
National Institute on Deafness and Other Communication Disorders (NIDCD)
Keywords provided by Margaretha L. Casselbrant, University of Pittsburgh:
For Patients and Families
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00422929
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ClinicalTrials.gov Identifier: NCT00422929
Eustachian Tube Growth and Development: Anatomy/Function
ENT Research Center, Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15224
Margaretha L. Casselbrant, Professor, Otolaryngology, University of Pittsburgh
NCT00422929
History of Changes
#0605009
5P50DC007667-06 ( U.S. NIH Grant/Contract )
January 17, 2007
Key Record Dates
Individual Participant Data (IPD) Sharing Statement:
otitis media
ear
acute otitis
middle ear
Eustachian tube
recurrent acute otitis media
chronic otitis media with effusion
no significant history of otitis media
Otitis
Otitis Media
Ear Diseases
Otorhinolaryngologic Diseases
https://support.google.com/youtube/answer/3159776?hl=en
https://clinicaltrials.gov/ct2/show/NCT00422929
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