Advantan merhem, %0,1, 15 g
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Topikal kortikosteroidlerle tedaviye duyarlı inflamatuar cilt hastalıkları: atopik dermatit, nörodermatit, çocukluk çağı egzaması; gerçek egzama; mikrobiyal egzama; mesleki egzama; dishidrotik egzema; basit kontakt dermatit; alerjik (kontak) dermatit. ilacın uygulama alanında tüberküloz veya sifilitik süreçler; ilacın uygulandığı bölgedeki viral hastalıklar (örneğin su çiçeği, herpes zoster); ilacın uygulama alanında rosacea, perioral dermatit; aşılamaya reaksiyon belirtileri olan cilt bölgeleri; 4 aya kadar çocuklar; ilacın bileşenlerine aşırı duyarlılık. 1 g metilprednizolon aseponat 1 mg Yardımcı maddeler: beyaz yumuşak parafin - 350 mg, sıvı parafin - 239 mg, beyaz balmumu - 40 mg, emülgatör Dehimuls E - 70 mg, arıtılmış su - 300 mg. Harici kullanım için merhem beyaz veya hafif sarımsı, homojen, opaktır. Emilim Perkütanöz emilimin derecesi derinin durumuna, dozaj formuna ve uygulama yoluna (tıkayıcı pansumanla veya pansumansız) bağlıdır. Bir merhem, krem veya yağlı merhem kullanıldığında, atopik dermatit (nörodermatit) ve sedef hastalığı olan çocuklarda ve yetişkinlerde perkütanöz emilim %2,5'ten fazla değildi; bu oran, sağlıklı gönüllülerle karşılaştırıldığında yalnızca biraz daha yüksektir (%0,5-1,5). emülsiyon formundaki ilaç Yapay iltihaplı deri yoluyla emilim oranı çok düşüktü (%0,27), bu oran sağlıklı deriden (%0,17) yalnızca biraz daha yüksektir. Tüm vücudun tedavisi durumunda (örneğin güneş yanığı durumunda), sistemik doz yaklaşık 4 mcg/kg vücut ağırlığı/gündür; bu, sistemik etkileri hariç tutar. Metilprednizolon aseponat, epidermis ve dermiste hidrolize edilir. Ana ve en aktif metabolit, cildin glukokortikoid reseptörleri için önemli ölçüde daha yüksek bir afiniteye sahip olan 6a-metilprednizolon-17-propiyonattır; bu, sistemik dolaşıma girdikten sonra ciltte biyoaktivasyonunun varlığını gösterir. -propiyonat glukuronik asit ile hızlı bir şekilde konjuge olur ve böylece 6a-metilprednizolon-17-propiyonat glukuronid formunda inaktive edilir. Metilprednizolon aseponatın metabolitleri esas olarak böbrekler tarafından elimine edilir, T1/2 yaklaşık 16 saattir. vücutta birikmez. Hamilelik ve emzirme döneminde Advantan ilacının kullanılması gerekiyorsa, fetusa yönelik potansiyel riski ve tedavinin anne için beklenen faydalarını dikkatlice tartmalısınız. Bu dönemlerde kullanılması tavsiye edilmez.
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