Adult I

Adult I
























































Adult I
Chemical structure of N -acetyllactosamine, the base unit in I and i antigens The Ii antigen system is a human blood group system based upon a gene on chromosome 6 and consisting of the I antigen and the i antigen. [1] The I antigen is normally present on the cell membrane of red blood cells in all adults, while the i antigen is present in fetuses and newborns. [2]
The adult i phenotype should provide a means of demonstrating the gene responsible for blood group I antigen expression. Similar investigations have been of great value in confirming the identities of several blood group genes—among them Lewis, 21 Secretor, 22 and Pk, 23 —as those responsible for controlling their respective blood group antigen expression. Like fetal RBCs and cord cells ...
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Adult i results from GCNT2 mutations. Although most cold agglutinins are Ii antibodies, many other specificities detect determinants on carbohydrate structures of membrane glycoproteins and glycolipids.
Adult human RBCs predominantly express I antigen, whereas fetal and neonatal RBCs predominantly express i antigen. After birth, I antigen levels increase gradually as i antigen levels fall, with the normal Ii status of adult RBCs reached after about 13 to 20 months.
Molecular genetic studies of 3 adult i pedigrees are reported here. The results obtained on mutation detection within the 2 I-branching enzyme encoding genes, segregation analyses, and enzyme function assays identify molecular changes associated with the adult i phenotype.
Molecular genetic analysis of the adult i phenotype may provide a means of identifying the blood group I gene, but it also may facilitate progress in uncovering the basis for the association of the adult i phenotype with a frequent occurrence of congenital cataracts in Asians.
Adult RBCs vary in the amount of I antigen expressed. The Ii antigens are found on the surface of most cells and on soluble glycoproteins in saliva, plasma and other fluids, and therefore they are known as histo-blood group antigens.
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