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Death may occur when Acetylfentanyl is combined with depressants such as opiates , benzodiazepines , barbiturates , gabapentinoids , thienodiazepines or other GABAergic substances. It is strongly discouraged to combine either heavy or moderate dosages of these substances together. WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Acetylfentanyl is a synthetic opioid substance of the piperidine chemical class that produces analgesic , anxiety suppressing , and euphoric effects when administered. It is a structural analog of fentanyl. Studies have estimated acetylfentanyl to be between five to fifteen times more potent than heroin , eighty times more potent than morphine , and fifteen times less potent than its parent compound, fentanyl. This compound has never been licensed for medical use and has only been sold as a designer drug. Acetylfentanyl was discovered at the same time as fentanyl and was rarely encountered on the illicit market in the late s as it was never commonly used. However, recently in , Canadian police discovered a group distributing over 3 kilograms and 12, pills of acetylfentanyl equal to , doses. The side effects of fentanyl analogs are similar to those of fentanyl itself, which include itchiness , nausea and potentially fatal respiratory depression. On the street market, it and its analogs are often misrepresented as traditional opioids like heroin due to its increased potency and substantially lower production costs. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early s. It is highly advised to use harm reduction practices such as volumetric dosing if choosing to use this substance. Acetylfentanyl is a member of the phenylpiperdine class of synthetic opioids. Its structure features a piperidine ring bound at its nitrogen constituent R N to a phenyl ring through an ethyl chain. The opposite carbon of the piperidine ring is bonded to the nitrogen member of a acetamide group, a two carbon chain with a nitrogen constituent adjacent to a carbon bonded to a ketone oxygen. This acetamide group is also substituted with an additional phenyl ring at R N. Acetylfentanyl is a structural homologue to fentanyl, with one less carbon on its amide chain. The way in which opioids structurally mimic these natural endorphins results in their physical euphoria , pain relief and anxiolytic effects. This is because endorphins are responsible for reducing pain, causing sleepiness, and feelings of pleasure. They can be released in response to pain, strenuous exercise, orgasm, or general excitement. Because of this, it can more easily penetrate the central nervous system in comparison to other opioids. Disclaimer: The effects listed below are cited from the Subjective Effect Index SEI , which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early s, and novel derivatives continue to appear. The United States Drug Enforcement Administration reported in July of that at least 52 confirmed fatalities involving acetylfentanyl in the United States had occurred between Ten fatalities attributed to acetylfentanyl overdose were reported during March of alone in Rhode Island. Fentanyl is potentially fatal at heavy dosages and even those with opiate tolerances are at high risk for overdoses. Because of the extremely high strength of pure acetylfentanyl powder, it is very difficult to dilute appropriately, and often the resulting mixture may be far too strong and, therefore, very dangerous. It is also potentially lethal when mixed with depressants like alcohol or benzodiazepines. Like most opioids, unadulterated acetylfentanyl at appropriate dosages does not cause many long-term complications other than extreme physical dependence and constipation. Outside of physical and psychological addiction , the harmful aspects of opioid usage are associated with not taking the necessary precautions in regards to its administration, overdosing on the substance and using impure products within the substance. It is important to consider that particular care must be taken with acetylfentanyl due to its extreme potency and ability to be absorbed through the skin. Heavy dosages of acetylfentanyl can result in respiratory depression , leading onto fatal or dangerous levels of anoxia oxygen deprivation. Acetylfentanyl can also cause nausea and vomiting; a significant number of deaths attributed to opioid overdose are caused by aspiration of vomit by an unconscious victim. This is when an unconscious or semi-conscious user who is lying on their back vomits into their mouth and unknowingly suffocates. It can be prevented by ensuring that one is lying on their side with their head tilted downwards so that the airways cannot be blocked in the event of vomiting while unconscious also known as the recovery position. In case of overdose, it is advised to administer a dose of naloxone intravenously or intramuscularly to reverse the effects of opioid agonism. It is strongly recommended that one use harm reduction practices when using this substance. As with other opioids , the chronic use of acetylfentanyl can be considered extremely addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal symptoms may occur if a person suddenly stops their usage. Tolerance to many of the effects of acetylfentanyl develops with prolonged and repeated use. The rate at which this occurs develops at different rates for different effects, with tolerance to the constipation-inducing effects developing particularly slowly for instance. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. Acetylfentanyl presents cross-tolerance with all other opioids , meaning that after the consumption of acetylfentanyl all opioids will have a reduced effect. The risk of fatal opioid overdoses rise sharply after a period of cessation and relapse, largely because of reduced tolerance. It has also been found that the environment one is in can play a role in opioid tolerance. In one scientific study, rats with the same history of heroin administration were significantly more likely to die after receiving their dose in an environment not associated with the drug in contrast to a familiar environment. Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations although it cannot be guaranteed to include all of them. Independent research e. Google , DuckDuckGo should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit. Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated. As such, it may contain incomplete or wrong information. You can help by expanding it. Physical effects. Cognitive effects. Visual effects. Janssen and C. Burger, Ed. Highly potent and on the rise in Europe'. International Journal of Drug Policy. PMID May—June Journal of Analytical Toxicology. ISSN Highly potent and on the rise in Europe PubMed. Science, , — Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95 4 , Retrieved December 29, Retrieved December 18, Bundesgesetzblatt Jahrgang Teil I Nr. Bundesanzeiger Verlag. June 20, Resmi Gazete. Retrieved January 15, Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Community Network YouTube Good vibes. Summary sheet: Acetylfentanyl. This legality section is a stub.

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Фентанил - аналоги и производные препарата

Acetylfentanyl acetyl fentanyl is an opioid analgesic drug that is an analog of fentanyl. Acetylfentanyl was discovered at the same time as fentanyl itself and had only rarely been encountered on the illicit market in the late s. However, in , Canadian police seized 3 kilograms of acetylfentanyl. Common side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching , nausea and potentially serious respiratory depression , which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early s, and novel derivatives continue to appear. Acetylfentanyl has been analytically confirmed in 32 fatalities in four European member states between and August , Germany 2 , Poland 1 , Sweden 27 and the United Kingdom 2. Twelve deaths have been associated with acetylfentanyl in Russia since The Centers for Disease Control and Prevention CDC issued a health alert to report that between March and May , 14 overdose deaths related to injected acetylfentanyl had occurred among intravenous drug users ages between 19 and 57 years in Rhode Island. After confirming five overdoses in one county, including a fatality, Pennsylvania asked coroners and medical examiners across the state to screen for acetylfentanyl. As a result of this investigation, Pennsylvania confirmed at least one acetylfentanyl overdose death and attributed at least 50 fatalities to either fentanyl or acetylfentanyl during the first half of As an analog of fentanyl, acetylfentanyl is a Schedule I controlled drug. As of October, acetylfentanyl is a controlled substance in China. Acetylfentanyl is a Schedule I controlled substance as of May Acetylfentanyl is illegal in Switzerland as of December Acetylfentanyl was made a class A drug as an analogue of fentanyl in Acetylfentanyl overdosage has been reported to closely resemble heroin overdosage clinically. Additionally, while naloxone Narcan is effective in treating acetylfentanyl overdose, larger than normal doses of the antidote may be required. Acetylfentanyl may be quantitated in blood, plasma or urine by liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalized patients or to provide evidence in a medicolegal death investigation. From Wikipedia, the free encyclopedia. IUPAC name. Interactive image. US Department of Justice. June Clinical Toxicology. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues'. Forensic Toxicology. Archived from the original PDF on Retrieved CBS News. Highly potent and on the rise in Europe'. The International Journal on Drug Policy. Journal of Analytical Toxicology. Journal of Analytical Chemistry. Morbidity and Mortality Weekly Report. Journal of Medical Toxicology. Forensic Science International. China Food and Drug Administration. Retrieved 1 October Retrieved 30 June Der Bundesrat. UK Home Office. February Analytical Chemistry. Disposition of toxic drugs and chemicals in man. Seal Beach, Ca. General anesthetics N01A. Fospropofol Propofol. Hexobarbital Methohexital Narcobarbital Thiopental Thiotetrabarbital. Alfadolone Alfaxalone Hydroxydione. See also: Recreational drug use. Analgesics N02A , N02B. Meloxicam Piroxicam. Meclofenamic acid Mefenamic acid. Cannabidiol Cannabis Nabilone Nabiximols Tetrahydrocannabinol dronabinol. Carbamazepine Lacosamide Local anesthetics e. Opioid receptor modulators. Namespaces Article Talk. Views Read Edit View history. By using this site, you agree to the Terms of Use and Privacy Policy. Phenols Fospropofol Propofol.

Acetylfentanyl

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Фентанил - аналоги и производные препарата

Acetylfentanyl

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