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Affinity and potency of novel synthetic cannabinoids in producing delta9-tetrahydrocannabinol-like effects in mice. Diversion of synthetic cannabinoids for abuse began in the early s. Despite legislation banning compounds currently on the drug market, illicit manufacturers continue to release new compounds for recreational use. Cannabinoids were examined in vitro for binding and activation of CB1 receptors, and in vivo for pharmacological effects in mice and in Delta9-THC discrimination. Preliminary analysis of urinary metabolites of the compounds revealed the expected hydroxylation. Further studies on these chemicals is likely to include research on understanding cannabinoid receptors and other components of the endocannabinoid system that underlie the abuse of synthetic cannabinoids. To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request. RTI uses cookies to offer you the best experience online. By continuing to use our website, you agree to the use of cookies. If you would like to know more about cookies and how to manage them please view our Privacy Policy. Learn More. Wiley, J. The Journal of Pharmacology and Experimental Therapeutics , 3 , Abstract Diversion of synthetic cannabinoids for abuse began in the early s. Publications Info To contact an RTI author, request a report, or for additional information about publications by our experts, send us your request. Recent Publications. Got it!

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