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Factors and methods to modulate DNA hybridization kinetics

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Priscilla Wilkins Stevens's research works

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DNA hybridization kinetics zippering internal displacement

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Physicochemical perspectives on DNA microarray and biosensor

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Kinetics and Dynamics of DNA Hybridization

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Kinetics and dynamics of DNA hybridization PubMed

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15 nov. 2024 · In this Account, we examine recent studies of the kinetics and dynamics of DNA hybridization, including (i) intramolecular collision of random coil, single-stranded DNA (ssDNA), (ii) nucleic acid hairpin folding, and (iii) considerations of DNA hybridization from both a global view and a detailed base-by-base view. 19 août 2024 · Graphical Abstract and Lay Summary. DNA hybridization is a key reaction in a broad range of research fields dealing with DNA oligonucleotides, such as analytical chemistry, molecular biology, nanotechnology, and drug delivery. Achieving high control and yield from this reaction is critical to ensure high-quality and reproducible results. Here, we explore DNA oligomer hybridization kinetics using a coarse-grained model. Strand association proceeds through a complex set of intermediate states, with successful binding events initiated by a few metastable base-pairing interactions, followed by zippering of the remaining bonds. But despite reasonably strong interstrand interactions.