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Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Anecdotal reports have described the subjective effects of 4-FA as having a moderate MDMA-like entactogenic onset for the initial few hours of the experience that then gradually transitions into traditional amphetamine-type stimulation for a total duration of around 6 to 8 hours with residual effects that can last a few hours afterward. Due to its strong psychostimulant effects, likely habit-forming properties as well as poorly understood toxicity profile, it is strongly recommended that one use proper harm reduction practices if choosing to use this substance. Amphetamines are alpha-methylated phenethylamines. The mechanism of action of 4-FA effectively boosts the levels of the norepinephrine, dopamine, and serotonin neurotransmitters in higher doses in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine, norepinephrine, and serotonin to accumulate within the brain, resulting in stimulating, euphoric and entactogenic effects. It is commonly reported that the first three to four hours of 4-FA present distinct entactogenic effects that have been reported as feeling somewhat similar to MDMA although not quite as powerful. This is thought to correlate with the duration in which it is promoting the release of serotonin in addition to dopamine and norepinephrine. After this first phase of the experience, the effect then shifts towards something which feels like classic amphetamine stimulation which can persist for an extended period. Do not use 4-FA if you have a history of heart-related issues or experience a severe headache after its use. In addition to the common amphetamine-like effects agitation, anxiety, tachycardia, hypertension, chest pain et al. Although a causal relationship has not been confirmed, when presented with a severe headache and lateralization after 4-FA usage, a medical evaluation at an emergency department should be conducted immediately. The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects should be taken with a grain of salt and will rarely if ever occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include injury or death. Anecdotal reports which describe the effects of this compound within our experience index include:. The toxicity and long-term effects of recreational 4-FA use have only scarcely been studied because 4-FA has very little history of human usage. Anecdotal evidence, as well as several case reports, suggest there is a small to moderate individual health risk associated with the use of 4-FA. Among these, it appears there is an especially a high risk for acute cardiovascular toxicity. Some people in the Netherlands, only using a moderate dose, have died due to cardiac arrest or suffered severe brain damage due to a stroke. The mechanism of this acute toxicity is not yet known, but it seems as though the stroke starts off as an intense headache or even a migraine attack, that slowly worsens. The LD 50 mouse; i. It is also worth noting that 4-FA is particularly caustic in comparison to other compounds and can, therefore, cause chemical burns within the nasal passage and throat if it is insufflated. This method of administration is discouraged. It is strongly recommended that one use harm reduction practices when using this substance. As with other stimulants , the chronic use of 4-FA can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Tolerance to many of the effects of 4-FA develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. This is how long it takes to reduce the tolerance for the stimulating effects. Tolerance for the entactogenic effects may take a longer period to reduce. Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. Combinations in the list below may increase the amount of neurotransmitters such as serotonin and dopamine to dangerous or even fatal levels. As such, it may contain incomplete or wrong information. You can help by expanding it. Amphetamines and Related Compounds. Treatment for amphetamine psychosis. A Handbook on Drug and Alcohol Abuse: The Biomedical Aspects 2nd ed. Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95 4 , Retrieved from ' https: All articles with unsourced statements Articles with unsourced statements Psychoactive substance Research chemical Stimulant Entactogen Amphetamine. Navigation menu Personal tools English Create account Log in. Views Read View source View history. Community Network Youtube Good vibes. This legality section is a stub.

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