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4-Methylmethamphetamine

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Stimulants is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects. Stimulants are widely used throughout the world as prescription medicines as well as without a prescription as performance-enhancing or recreational drugs. The most frequently prescribed stimulants as of were lisdexamfetamine, methylphenidate, and amphetamine. It is estimated that the percentage of the population that has abused amphetamine-type stimulants and cocaine combined is between 0. A drug is any substance that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a physiological change in the body. Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents. The compounds in this class span a variety of pharmacological subclasses, including stimulants, empathogens, and hallucinogens, among others. Examples of substituted amphetamines are amphetamine itself , methamphetamine, ephedrine, cathinone, phentermine, mephentermine, bupropion, methoxyphenamine, selegiline, amfepramone, pyrovalerone, MDMA ecstasy , and DOM STP. It is an agonist of human TAAR1. It has been reported to be sold as a designer drug, but little is known about its pharmacology or toxicology. It was first detected from legal highs sold in Japan in and became illegal to sell or to possess for the purpose of distribution in Japan in It was initially reported to be contained as an ingredient in some of the range of party pills sold internationally by the Israeli company Neorganics from around onwards, but this was later shown to be incorrect and this ingredient was eventually identified as the closely related compound 2-fluoromethamphetamine. Empathogens or entactogens are a class of psychoactive drugs that produce experiences of emotional communion, oneness, relatedness, emotional openness—that is, empathy or sympathy—as particularly observed and reported for experiences with 3,4- Methylenedioxymethamphetamine MDMA. This class of drug is distinguished from the classes of hallucinogen or psychedelic, and amphetamine or stimulant. Entactogens are sometimes incorrectly referred to as hallucinogens or stimulants, although many entactogens such as ecstasy exhibit psychedelic or stimulant properties as well. Methylone is an empathogen and stimulant psychoactive drug. It is a member of the substituted amphetamine, substituted cathinone and substituted methylenedioxyphenethylamine classes. Ethylone , also known as 3,4-methylenedioxy- N -ethylcathinone , is a recreational designer drug classified as an entactogen, stimulant, and psychedelic of the phenethylamine, amphetamine, and cathinone chemical classes. Ethylone has only a short history of human use and is reported to be less potent than its relative methylone. In the United States, it began to be found in cathinone products in late PMMA is the 4-methoxy analog of methamphetamine. Little is known about the pharmacological properties, metabolism, and toxicity of PMMA; because of its structural similarity to PMA, which has known toxicity in humans, it is thought to have considerable potential to cause harmful side effects or death in overdose. Methedrone is a recreational drug of the cathinone chemical class. Chemically, methedrone is closely related to para -methoxymethamphetamine PMMA , methylone and mephedrone. Methedrone received media attention in after the death of two young Swedish men. In both cases toxicology analysis showed methedrone was the only drug present in both men during the time of their overdose and subsequent deaths. Mephedrone , also known as 4-methyl methcathinone 4-MMC or 4-methyl ephedrone , is a synthetic stimulant drug of the amphetamine and cathinone classes. It is chemically similar to the cathinone compounds found in the khat plant of eastern Africa. It comes in the form of tablets or a powder, which users can swallow, snort or inject, producing similar effects to MDMA, amphetamines and cocaine. Ethcathinone , also known as ethylpropion or ETH-CAT , is a stimulant drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is an active metabolite of the prodrug diethylcathinone and is fully responsible for its effects. Ethcathinone has been identified as an ingredient in both quasi-legal 'party pills', and, along with mephedrone, has also been reported as having been sold as 'ecstasy' in the Australian city of Cairns. Nichols at Purdue University. It acts as a non-neurotoxic and highly selective serotonin releasing agent SSRA in vitro and produces entactogen effects in humans. It was first synthesized in and was encountered as a street drug in Italy in the same decade. MMA was largely forgotten until being reassayed by David E. Nichols as a non-neurotoxic MDMA analogue in , and has subsequently been sold as a designer drug on the internet since the late s decade. A norepinephrine releasing agent NRA , also known as an adrenergic releasing agent , is a catecholaminergic type of drug which induces the release of norepinephrine noradrenaline and epinephrine adrenaline from the pre-synaptic neuron into the synapse. This in turn leads to increased extracellular concentrations of norepinephrine and epinephrine therefore an increase in adrenergic neurotransmission. Ortetamine INN , also known as 2-methylamphetamine , is a stimulant drug of the amphetamine class. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through the blood—brain barrier, as is desirable in central nervous system pharmaceutical agents, is a common practice due to the corresponding increase in lipophilicity granted by the substitute. It has similar effects in animal drug discrimination tests to the more widely known derivative 4-methoxyamphetamine PMA , although with a slightly different ratio of monoamine release, being a combined serotonin, dopamine, and norepinephrine releasing agent rather than a fairly selective serotonin releaser like PMA. It produces gepefrine, a cardiac stimulant, as one of its major metabolites. It is a structural isomer of flephedrone. It is purported to possess little recreational value because less euphoria is produced than other amphetamines. It is said to be a functional stimulant with properties similar to Adderall. Due to its similarity to mephedrone, it is thought to be a stimulant and entactogen drug of the phenethylamine, amphetamine, and cathinone chemical classes. It has been marketed alone or in mixtures with other substituted cathinones under the name ' NRG-2 ', although other blends such as 'NRG-1' may have been more ambiguous with their ingredients. The name derives from instances in which the drugs were disguised as bath salts. The white powder, granules, or crystals often resemble bath salts such as Epsom salts, but differ chemically. Recreational drugs have also been disguised as plant food, hookah cleaner and other products. However, 3-MMC has still appeared on the recreational drug market as an alternative to mephedrone, and was first identified being sold in Sweden in Unlike other legal highs 3-MMC was tested and characterized in large mammals, providing much more knowledge about it than is known about other synthetic cathinones. It is a metabolite of the better known drug mephedrone 4-methylmethcathinone. IUPAC name. Interactive image. Analytical and Bioanalytical Chemistry. Substituted amphetamine Sub. PEA Sub. Adapromine Amantadine Bromantane Memantine Rimantadine. Oxiracetam Phenylpiracetam Phenylpiracetam hydrazide. ATC code : N06B. Monoamine releasing agents. Oxazolines: 4-Methylaminorex Aminorex Clominorex Fluminorex. Others: Indeloxazine Viqualine. Images, videos and audio are available under their respective licenses.

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