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It is banned in many countries as a stimulant. The results of animal experiments conducted with this drug suggest that it has an abuse liability similar to cocaine and amphetamine. Vehicle or 4-methylaminorex doses were substituted for cocaine. One of the two different doses of 4-methylaminorex maintained self-administration behavior above vehicle control levels. Alternate synthesis routes generally involve more steps, such as replacing cyanogen bromide with sodium or potassium cyanate to form an intermediate and then reacting it with concentrated hydrochloric acid. A method reported in microgram replaced the need for a separate addition of hydrochloric acid by starting with the hydrochloride salt of the dl-phenylpropanolamine but side-products are noted. The cyanate reaction proceeds differently from the cyanogen bromide and transforms norephedrine into transmethylaminorex instead, as noted in the DEA micrograph. The cyanogen bromide, by comparison, transformed norephedrine into the cis isomer and norpseudoephedrine into the trans isomers of the final product. As an anorectic , the ED50 is 8. In the s McNeil Laboratories , Inc. They mention also LD There is a patent about the use of 4-methylaminorex 'as a nasal decongestant which, when administered orally, does not produce adverse central nervous system stimulant effects as experienced with other decongestants and anorexiants. It produces long-lasting effects, generally up to 16 hours in duration if taken orally and up to 12 hours if smoked or insufflated. Large doses have been reported anecdotally to last up to 36 hours. The effects are stimulant in nature, producing euphoria , an increase in attention, and increased cognition. Anecdotally, it has been reported to produce effects similar to nootropics , however, there is no research to support the claim that it is any different or more effective than other psychostimulants in this respect. Moreover, 4-methylaminorex does not have the established safety profile of widely used clinical psychostimulants such as methylphenidate and dextroamphetamine. There has been one reported death due to 4-methylaminorex and diazepam. Concentrations of 4-methylaminorex were: Diazepam concentration in blood was 0. Also another study has studied pharmacokinetics and tissue distribution of the stereoisomers of 4-methylaminorex in rats. A similar compound, 4-methylaminorex was discovered on the property of three individuals with diagnoses of pulmonary hypertension. There have been three studies studying possible neurotoxicity of 4-methylaminorex. It was reported that although multiple doses of 4-methylaminorex caused long-term 7 days declines in striatal tryptophan hydroxylase activity in SD rats, no changes were found in 5-HT and 5-HIAA levels Hanson et al. That first study \\\\\\\\\\\\\\\\\[11\\\\\\\\\\\\\\\\\] also suggested reduced dopamine DA levels a possible marker for dopamine neurotoxicity , but citing study: In Australia , 4-Methylaminorex is listed as Schedule 9, making it legal only for scientific and medical research. In the Netherlands , aminorex 4-methylaminorex is a designer drug is a List I drug of the Opium Law. To clarify the situation, the US Drug Enforcement Administration published a paper in its DEA Microgram Journal , regarding interpretation of the relevant statutory law as it relates to the status of trans methylaminorex. In summary, according to this non-legally binding decision, trans methylaminorex is not currently a controlled substance, but a potential analogue. In fact, the report explicitly states:. However, the opinion does say that the agency considers the substance a potential controlled substance analogue , making the substance identical to a Schedule I substance if intended for human consumption, according to the Federal Analogue Act. The report gives an account of a successful conviction under the Federal Analogue Act of an offense involving the trans isomer. From Wikipedia, the free encyclopedia. D Evidence of risk. Anlage I Authorized scientific use only UK: Archived from the original on Archived from the original on 27 August Adapromine Amantadine Bromantane Memantine Rimantadine. Oxiracetam Phenylpiracetam Phenylpiracetam hydrazide. SoRI Adrenergic release blockers: Retrieved from ' https: Stimulants Euphoriants Amines Designer drugs Serotonin-norepinephrine-dopamine releasing agents Oxazolines. Views Read Edit View history. This page was last edited on 8 May , at By using this site, you agree to the Terms of Use and Privacy Policy. Oral , Vaporized , Insufflated , Injected.

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