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Description: Genz is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, .
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Here, we identified two previously described glucosylceramide (GlcCer) synthase inhibitors, DL-threoPhenylpalmitoylaminomorpholinopropanol and Genz(Genz), as enhancers of .
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DOI: /[HOST]t Abstract Environmental contamination by secondary explosive has been posing threat to human health and the ecosystem. We investigated the potential of a novel bioformulation developed from poultry waste for the bioremediation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) contaminated soils.
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