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NMN (Nicotinamide Mononucleotide),

NMN (Nicotinamide Mononucleotide),

Hemiplegia with crooked mouth is not inevitable. This new discovery may kill stroke in the cradle.

In fact, aging is an important cause of various neurological diseases. Factors related to aging may damage brain cells, and the incidence of stroke in the elderly is as high as 20% - 30%. An article in 003010 magazine analyzed the etiology according to age distribution and found that stroke is closely related to cerebrovascular aging.

At present, many researchers believe that the dysfunction of neurovascular units (composed of neurons, glial cells and blood vessels) has a significant impact on cardiovascular and cerebrovascular injury. In 2016, the research team led by Dr. Chen Jun of the University of Pittsburgh School of Medicine published an article in the Journal of thrombosis and thrombosis, pointing out that aging will increase the sensitivity of neurovascular units to stroke, prevent or treat the damage of neurovascular units, reduce the possibility of stroke, and even delay aging.

One of the effective methods is to eliminate the harmful factors related to aging in neurovascular units. Many studies have shown that the decrease of NAD with age is an important factor affecting neurovascular dysfunction (the introduction of NAD has been described in detail in our previous articles and is the core coenzyme of cellular redox reaction). Therefore, restoring nad level may effectively prevent and treat stroke.

Surprisingly, in 2019, a study by the University of Oklahoma Health Science Center found that nicotinamide mononucleotide (NMN) can rely on deacetylase to restore cell nad level, reverse vascular aging and effectively save neurovascular function. In 2020, this finding was further verified in another mouse model study.