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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are often described as focusing on practical aspects of study design that include the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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Pragmatic, a software company provides a variety of casino games on online gambling platforms. Pragmatic's iGaming software is used by the top operators and land based casinos. The company offers front-end website design tools, analysis tools and promotions, marketing security payment systems, customer service, and bug reporting. The company also provides security, high-quality graphics, games and security.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and participants from different geographical regions. This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity and also reduces the chance of bias in the results. However excessive heterogeneity could cause problems with the design of the trial.
Pragmatic Play Pragmatic Play, a major player on the live casino market offers various classic table games like Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic gambling experience, as well as a broad selection of virtual betting options. The company also has created numerous interactive game shows that make online gambling fun. Some of these shows have live hosts, whereas others are hosted by celebrities from the industry.
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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are usually commissioned by practitioners and policy makers to guide their decision-making. They also provide a useful way to identify the cause-effect relationship between an intervention and its outcomes. They should, however, not, be used to replace explanation studies.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials, which guide policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study that includes the recruitment, design, and delivery of the intervention, and follow-up.
There is an encouraging trend in the number of pragmatic trials published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority were conducted in primary-care settings.