See morepin 14heart 4Nutrition HealingDiet NutritionNutrition ArticlesHealth ArticlesHealth TipsSaving BenefitsHealthy StudentSynthetic VitaminsHealthy IdeasForwardThis is a detailed article about Vitamin K2, an incredibly important nutrient that may have life-saving benefits for a lot of people. /vitamin-k2/See morepin 1Nutrient VitaminHigh VitaminVitamin K2Foods With Vitamin KSoluble NutrientVitamin InfoFat SolubleEssential NutritionNutrition BasicsForwardTen Foods Loaded with Vitamin K2See morepin 8D3 180180 McgCapsules SuppliesSupplies 5K2 CapsulesK2 30Mercola Vitamins000 Iu5 000ForwardDr Mercola Vitamins D and K2 - 30 Capsules - Supplies 5,000 IU Of Vitamin D3 and 180 mcg Of Vitamin K2 A MK-7 - Vitamin K2 Produced From Chickpeas - Supports Heart Health and Vascular System ** Want additional info? Click on the image.See morepin 17heart 14Fat Soluble VitaminVitamin OilVitamin ButterHigh VitaminHealth DetoxHealth HealingHealth NutritionHealth And WellnessHealth BeautyForwardVitamin K2 is a little known but extremely important fat-soluble vitamin.
We classically think of Vitamin K for it's role in blood clotting,See moreI call Vitamin K2 the "Cradle to Grave" nutrient as we ALL need it every day of our lives. We don't store Vitamin K2 like we do the other fat soluble vitamins so we have to have it daily. Listen in to find out 10 ways Vitamin K2 can change your life! // @ondietandhealthpin 2heart 1Single VitaminVitamin K2Find ReliableVibrationsDeservesMeantResourceAttentionReasonForwardIf there’s a single vitamin you need to know more about, it’s vitamin K2. The first reason is you’re probably not getting enough. The second is that it doesn’t get the attention it deserves, and it’s really hard to find reliable and easy-to-use information about it. This resource is meant to change that. See morepin 21heart 2Unrecognized VitaminHealth ReducedReduced RiskVit K2Health And Wellness ArticlesHealth WellnessHealth BoneVitamin K2Health BenefitsForwardHealth benefits of the unrecognized vitamin K2See moreControls RemovalK2 ControlsVitamins Minerals AntioxidantsMedicine TopicHippocratic CookingDaily NourishmentRemedies FoodNatural RemediesD3 VitaminForwardvitamin k2 controls removal of calcium from arteries and deposition of calcium into bones... at The Truth in Medicine
, topic 1709580See moreBelow you can find the latest 25 reviews. To access the full list please click here This is the first time i have bought this, so i need to wait and see. Just feel alone better when I take it Well it is hard to know how well the vitamins etc are working! Very pleased, have been taking this product along with Calcium and Vit D for a long time. Great value excellent product Excellent product delivered on time. Thank you for your review. from start to finish all good Thank you for taking the time to leave a review. Strong compact packaging and good price We aim to provide the highest standard of products without compromising on quality. Value for money and conveniently packaged I simply cannot rate the product (yet) because it will take months to see results in blood tests. Very quick reviews of changes in supplementation seem quite suspect to me. So I can only give one star as in all conscience I cannot give the product a positive review YET - but I'm unable to "escape" from giving the review of Healthspan's service (very good) without rating the product as well.
We would recommend this product be taken for a minimum of 6 to 8 weeks, however maximum benefits may not be obtained until at least 3 to 4 months of continuous usage. good product astray all are Thank you for your review - We appreciate your comments. use all the time. A good support to my chondromax. Recommended by my PMR support group. Thank you for your feedback. Healthspan is a great company with excellent products. It is great to hear we are doing a good job. Take along with prescribed calcium. Very good product happy with this Good for bone care and blood condition. It's great to hear you are pleased with the products - Nicola God strength at good price good complement to calcium and vit d that I get on prescription The vitamin required for blood klotting Molecule of the Month May 2016Also available: JSMol version. You�ve spelled �clotting� incorrectly! Actually it was deliberate. Unlike the other vitamins, A, B, C, etc., which were named alphabetically in the order in which they were discovered, vitamin K was called �K� for a reason.
In 1929, Danish scientist Henrik Dam was studying the role of cholesterol in diet. He did this by feeding chickens a cholesterol-depleted diet, and seeing what this did to the chickens. After a few weeks the chickens started bleeding profusely. However, it wasn�t the missing cholesterol that was causing the problem. In the chemical process to remove the cholesterol from the feedstock, another compound had also been inadvertently removed. When this compound was added back to the feedstock, the chickens became normal. Dam realised that the mystery compound was necessary for blood clotting, and so called it the �coagulation vitamin�. The new discovery was then reported in a German Journal, where it was called Koagulationsvitamin, and thereafter renamed in English as Vitamin K. Dam worked with American scientist Edward Doisy to work out the biological effects of Vitamin K as well as its structure. They both shared a Nobel Prize in Medicine for this work. Actually, �vitamin K� is the name given to a group of similar molecules that all act in the same way.
They are essential vitamins that the body needs in order to make the proteins for blood clotting. There are 5 types of vitamin K, denoted K1-K5, although only K1 and K2 are naturally occurring; the other three are man-made and are used sometimes as dietary supplements. The K vitamins are all based on derivatives of 2-methyl-1,4-naphthoquinone. The most important source of these is K1, which has a long sidechain (called a phytyl group) attached to the quinone, giving it the chemical name phylloquinone. It�s found in high concentrations in green leafy plants, such as curly kale, spinach, broccoli, and cabbage. Well, obviously not for clotting blood! Plants actually use vitamin K1 for another role, as an electron acceptor during photosynthesis. In this process, sunlight is captured by chlorophyll molecules, which causes an electron to be excited to a higher energy level. As the electron relaxes back down to its normal level, the excess energy is transferred to nearby molecules (one of which is vitamin K1) allowing them to be either oxidised (lose electrons) or reduced (gain electrons).
The electrons are passed along a chain of molecules in a sequence of oxidation-reduction steps, until they are eventually used to drive the reaction turning CO2 and water into sugars and O2.After we eat foods containing vitamin K1, around 75% of the K1 will be converted in our bodies to vitamin K2, which is the real workhorse when it comes to blood clotting. In fact, there are many different sub-types of vitamin K2, depending on the length of the sidechain. The first step in the conversion is to replace the phytyl chain with one containing an unsaturated geranylgeranyl group (4 isoprene units in a line). This new compound is called menaquinone, or MK-4. The �M� stands for menaquinone, the �K� for vitamin K, and the �4� for the four isoprene units (CH2=C(CH3)CH=CH2) in the sidechain. Other types of Vitamin K2 exist with different sidechain lengths, such as MK-7, MK-9, etc.; these are not synthesised by animals, but by bacteria in our guts. They undoubtedly assist MK-4 with the bloodclotting process, but by how much, and what their exact role is, is still unclear.
The key chemistry is that the quinone group can be easily reduced and reoxidised, via an epoxide intermediate, using various enzymes. The actual biochemical pathway, called the Vitamin K cycle, is complex, but the net effect is that a COOH group can be added to a nearby protein (such as prothrombin). The proteins involved in blood coagulation, such as prothrombin, have at their amino terminus, typically 9 to 12 glutamic acid sidechains. The vitamin K cycle adds a second COOH group to the end of the chain, to make a so-called gamma-carboxy-glutamic acid. The two adjacent COOH groups now make the protein extra �sticky�, especially to calcium ions, which can now chelate (bond) to them directly. The trapped calcium ion is now able to form an ionic bond to the phosphate head-groups of phospholipid membrane surfaces. Once the protein (prothrombin) is stuck to the lipid wall, another enzyme can convert it to thrombin, whose key role is to cut up fibrinogen, an inactive circulating plasma protein, into soluble fibrin monomers.
These reactive monomers then spontaneously aggregate to form a spaghetti-like network, clotting the blood. The other useful effect that results from the binding of Ca2+ ions is that these ions are removed from the bloodstream (where they might eventually clump together and form calcified blockages of arteries), and can be donated to proteins that can do something useful with them, such as make bones. Indeed, one of the symptoms of vitamin K deficiency is weak bones, while one of the treatments for osteoporosis is to take vitamin K supplements. Ah, these are the man-made analogues called vitamin K3, K3 and K3. Because these are not found in nature, strictly speaking they are not true vitamins, but due to their similarity in structure and effect to vitamins K1 and K2 they have co-opted the name. They are synthesised mainly for use as nutritional supplements for use by people with illnesses or ailments that cause vitamin K deficiency. A healthy adult with a normal diet can normally get all the vitamin K needed from eating a few green vegetables regularly.
But newborn babies are relatively deficient in vitamin K because they have low vitamin K stores at birth. This is because the levels of vitamin K in breast-milk are low, and what little there is does not pass easily through the placenta. Also, a baby�s gut bacteria have not yet been developed so they cannot synthesise their own vitamin K2. This puts newborns at risk of �Haemorrhagic disease of the newborn� (excessive or uncontrolled bleeding), so to prevent this many newborns are given a vitamin K supplement at birth. If a person has damage to the liver or gut where vitamin K2 is synthesised, then they may have a deficiency also, and become susceptible to uncontrolled bleeding. Patients that take warfarin are also at risk. It�s a drug that�s used to prevent blood clotting in patients where excessive clotting is dangerous, especially in areas of slowly running blood such as in veins and the pooled blood behind artificial and natural heart valves. Commonly, warfarin is used to treat ailments such as atrial fibrillation, deep-vein thrombosis, and pulmonary embolism.
It works by inhibiting vitamin K epoxide reductase (VKOR), the enzyme that converts vitamin KO back to vitamin K in the vitamin K cycle, above. This means the vitamin K is not regenerated, and as it is used up so its concentration falls, and the blood-clotting mechanism slows. People who are on warfarin treatment are usually advised to be very careful about how many green leafy vegetables they eat, as their high vitamin K content can negate the effect of the warfarin � or make it difficult for the body to regulate how much vitamin K is present at any one time. Yes, because it prevents rats� blood from clotting too. This means that after eating warfarin-laced food bait, any slight scratch, scrape or injury that the rat might experience causes it to bleed to death. Nowadays, though, the use of warfarin as a rat poison is declining because many rat populations have developed resistance to it. It�s being replaced by more potent and longer acting poisons such as coumatetralyl and brodifacoum [see the MOTM page on warfarin].