Having trouble logging in? Sign up for a free account Get unlimited access on Medscape. What vitamins can lower your uric acid levels? Research has shown that increased intake of vitamin C can lower the level of uric acid, according to WebMD. Boosting the intake of vitamin E can also reduce uric acid levels in the blood, reports the National Center for Biotechnology Information. What vitamin is good for inflammation? When should you take vitamin D? How can you diet to reduce uric acid? The breakdown of purines leads to the creation of a chemical called uric acid, and foods like liver, dried beans, and beer contain it, states MedlinePlus. High levels of uric acid in the blood lead to the creation of crystals and thus gout, reports WebMD. Men who take very high concentrations of vitamin C are 45 percent less likely to develop the most painful conditions of gout than those who receive very low levels. Vitamin C is a supplement that occurs naturally in citrus fruits, broccoli and other fruits, according to WebMD.
The risk of gout reduces by 15 percent for every 500 milligrams of vitamin C intake. Thus, consistent intake of vitamin C is an efficient way of reducing the risk of getting gout. A study performed on rats has shown that increased intake of vitamin E can lower the level of uric acid in the blood, according to the National Center for Biotechnology Information. Administration of about 200 milligrams of vitamin E per day lowered uric acid levels as well as blood pressure. Learn more about Vitamins & Supplements What are the best foods to eat and avoid if you have excess uric acid? Individuals with high uric acid levels should drink plenty of fluids, particularly water, and eat a diet high in whole grains, fruits and vegetables. What is a high uric acid level? A high uric acid level means a person's body is producing too much uric acid or the kidneys aren't excreting enough from the blood stream. Medical Ranges & Levels What are the symptoms of high uric acid?
A high uric acid level can cause gout, kidney stones and even kidney failure, Mayo Clinic states. Results of a high uric acid level are unpredictable, howe... What is the normal range of uric acid in the blood? The normal range of uric acid in the blood for adult men is 3.4 to 7.0 mg/dL, while the normal range for adult women is 2.4 to 6.0 mg/dL, according to WebM... What is the correct dosage of black cohosh? How much Lecithin should you take a day? What are some warnings about Emergen-C? What is crown of thorns extract? How does low calcium impact the body? What are the main benefits of taking vitamin D3?While dietary supplements may be widely used for gout, this review has shown a paucity of high-quality evidence assessing dietary supplementation. Dietary supplements are frequently used for the treatment of several medical conditions, both prescribed by physicians or self administered. However, evidence of benefit and safety of these supplements is usually limited or absent.
To assess the efficacy and safety of dietary supplementation for people with chronic gout. We considered all published randomised controlled trials (RCTs) or quasi-RCTs that compared dietary supplements with no supplements, placebo, another supplement or pharmacological agents for adults with chronic gout for inclusion. Dietary supplements included, but were not limited to, amino acids, antioxidants, essential minerals, polyunsaturated fatty acids, prebiotic agents, probiotic agents and vitamins. The main outcomes were reduction in frequency of gouty attacks and trial participant withdrawal due to adverse events. We also considered pain reduction, health-related quality of life, serum uric acid (sUA) normalisation, function (i.e. activity limitation), tophus regression and the rate of serious adverse events. We used standard methodological procedures expected by The Cochrane Collaboration. We identified two RCTs (160 participants) that fulfilled our inclusion criteria. As these two trials evaluated different diet supplements (enriched skim milk powder (SMP) and vitamin C) with different outcomes (gout flare prevention for enriched SMP and sUA reduction for vitamin C), we reported the results separately.
One trial including 120 participants, at moderate risk of bias, compared SMP enriched with glycomacropeptides (GMP) with unenriched SMP and with lactose over three months. Participants were predominantly men aged in their 50's who had severe gout. The frequency of acute gout attacks, measured as the number of flares per month, decreased in all three groups over the study period. The effects of enriched SMP (SMP/GMP/G600) compared with the combined control groups (SMP and lactose powder) at three months in terms of mean number of gout flares per month were uncertain (mean ± standard deviation (SD) flares per month: 0.49 ± 1.52 in SMP/GMP/G60 group versus 0.70 ± 1.28 in control groups; mean difference (MD) -0.21, 95% confidence interval (CI) -0.76 to 0.34; low-quality evidence). The number of withdrawals due to adverse effects was similar in both groups although again the results were imprecise (7/40 in SMP/GMP/G600 group versus 11/80 in control groups; risk ratio (RR) 1.27, 95% CI 0.53 to 3.03; low-quality evidence).
The findings for adverse events were also uncertain (2/40 in SMP/GMP/G600 group versus 3/80 in control groups; RR 1.33, 95% CI 0.23 to 7.66; Gastrointestinal events were the most commonly reported adverse effects. Pain from self reported gout flares (measured on a 10-point Likert scale) improved slightly more in the SMP/GMP/G600 group compared with controls (mean ± SD reduction -1.97 ± 2.28 points in SMP/GMP/G600 group versus -0.94 ± 2.25 in control groups; MD -1.03, 95% CI -1.96 to -0.10; This was an absolute reduction of 10% (95% CI 20% to 1% reduction), which may not be of clinical relevance. Results were imprecise for the outcome improvement in physical function (mean ± SD Health Assessment Questionnaire (HAQ)-II (scale 0 to 3, 0 = no disability): 0.08 ± 0.23 in SMP/GMP/G60 group versus 0.11 ± 0.31 in control groups; MD -0.03, 95% CI -0.14 to 0.08; Similarly, results for sUA reduction were imprecise (mean ± SD reduction: -0.025 ± 0.067 mmol/L in SMP/GMP/G60 group versus -0.010 ± 0.069 in control groups;