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The IP address used for your Internet connection is part of a subnet that has been blocked from access to PubMed Central. Addresses across the entire subnet were used to download content in bulk, in violation of the terms of the PMC Copyright Notice. Use of PMC is free, but must comply with the terms of the Copyright Notice on the PMC site. For additional information, or to request that your IP address be unblocked, For requests to be unblocked, you must include all of the information in the box above in your message.BioZkin Sublingual Vitamin B12 Methylcobalamin 50 ml (100 doses) / x 1 - $18.39 USD 50 ml (100 doses) / x 2 - $34.50 USD 50 ml (100 doses) / x 5 - $83.75 USD 50 ml (100 doses) / x 10 - $162.50 USD 30 ml (60 doses) / x 1 - $14.99 USD NPN 80071825: Health Canada Licensed Natural Health Product Vitamin B12 is an essential nutrient that has an important impact on your immune system, nervous system and red blood cell formation. Vitamin B12 deficiency is one of the most common nutritional deficiencies.




Recent studies from the US Framingham trial indicate that 25% of adults in the US are deficient and nearly 50% of the population has suboptimal levels of B12. Sublingual B12 Vitamin Benefits Red blood cell formation and iron utilization Nervous system cells and associated functions such as memory, concentration and mental clarity Stabilized moods and feelings of well-being Increased melatonin production which affects sleep Digestive and metabolic health Liver and heart health Vegetarian and vegan lifestyles Free of gluten, wheat, dairy, animal byproducts, yeast, artificial colors and sweeteners Sublingual - Vitamin B12 requires intrinsic factor, a glycoprotein produced by the cells of the stomach, to absorb. Aging, digestive function and other health factors can affect production of intrinsic factor. Because of this tendency towards mal-absorption, doctors often use injections to provide patients with a guaranteed amount of B12. The best way to bypass the need for intrinsic factor is to take the supplement under the tongue (sublingually) which allows it to enter the blood stream through the mucous membranes.




Less painful than an injection and just as effective. Methylcobalamin - The earlier generation of supplemental vitamin B12 was known as cyanocobalamin. This was an inactive form and required conversion by the body into something that could be utilized. BioZkin's B12 is known as methylcobalamin; it is considered to be an active form of B12, immediately available for use by the body. Studies comparing cyanocobalamin to methylcobalamin in cancerous rats showed that only the methyl form prolonged their lifespan. BioZkin B12 Sublingual Methylcobalamin is a superior form of B12 and does not need conversion, it is immediately available for use by the body. As the earlier generation of B12 is known as cyanocobalamin, it is an inactive form and requires conversion by the body into something that the body can utilize. Where Methylcobalamin is an active form of B12, immediately available for use by the body. BioZkin B12 Sublingual Methylcobalamin is taken sublingually (under tongue) which allows it to effectively enter the blood stream through the mucous membranes.




Perfect for those adverse to injections and many times more effective than any pill form. Easy to take and has a pleasant taste.To obtain 1000 mcg of B12 the serving size is: 0.5 ml (15 drops) Clean Ingredients: Methylcobalamin Vitamin B12, Vegetable Glycerine, Potassium Sorbate, Citric Acid, Purified Water. Made in a quality controlled GMP facility. Supplement Facts Serving Size: 0.5 ml (15 drops) Servings Per Container: 100 B12 (Methylcobalamin) 1000 mcg BioZkin B12 Plus+ Cream BioZkin B12 Plus+ Cream & Pure Damask Rose Squalene Serum Gift Set BioZkin Baby Vitamin D Drops BioZkin Breast Booster (BBB)Please Note: SHOTS, etc. is now able to file for insurance reimbursement from most of the plans administered by United Healthcare, CIGNA and Blue Cross/Blue Shield. We are joining other insurance networks, as well, but it takes time. All patients receiving vaccines and/or lab tests will be charged a $30 consultation fee. SHOTS, etc. offers the following vaccines to help keep you healthy at work, at school and at play!




Please click on the individual vaccine name to be linked to some very important information that you need to know before taking that vaccine. You may also find more information about these vaccines and the diseases they prevent by clicking on the vaccine information button on the left side bar or by visiting the CDC Website. If you do not see the name of the blood test you desire, please call our office for special pricing. Please note that we do not draw blood for testing on Saturdays. Click here to download a free adobe acrobat file for reading the specific vaccine information. PLEASE NOTE: All of the following vaccines and services are available at all three of our office locations BY APPOINTMENT. However, If you are receiving services at your school or place of business or at one of our Community Wellness Clinics, please be aware that the nurse carries only flu, tetanus and pneumonia vaccines in addition to Vitamin B12 injections. If you desire to receive any other vaccines or services at your on-site appointment, you must request them from our office one week IN ADVANCE of the scheduled appointment date.




We accept payment for services in our office by cash, check, credit or debit card. If you wish to pay by credit or debit card for services rendered at your office appointment or at a Community Wellness Clinic, you MUST prepay on our website through the security of PayPal. Simply click on the name of the vaccines or services you desire, complete the payment process, print your receipt and give it to the nurse at your appointment location. Please note that due to variations in manufacturers' charges, these prices are subject to change. * If you are required to take Yellow Fever vaccine or Meningococcal vaccine in order to apply for your VISA, please call as soon as possible for your appointment as the vaccine should be given at least 10-14 days prior to travel or sooner if you must apply for a VISA. Thank you for allowing SHOTS, etc. the privilege of serving your vaccination and wellness needs!Join our mailing list What is B12 deficiency? What are the causes?




What to do next? Who is at risk? B12 and mental health B12 - Writing to your doctor Male and female infertility About the B12 Apps How YOU can help Hydroxcobalamin injections are used to treat B12 deficiency by the NHS in the UK. It is a very stable form of B12 and is It is converted to methylcobalamin and adenosylcobalamin in the body. In the UK injectable B12 is only available on prescription. It is used in huge quantities as a treatment for cyanide poisoning. It is also used in the treatment of Leber's optic atrophy. If B12 deficiency is due to malabsorption, injections will be required for life. Once diagnosed, correct treatment is a loading dose; intramuscular B12 injections of hydroxycobalamin every other day for two weeks. This frequency should continue for patients with neurological involvement, until all symptoms stop improving, followed by lifelong maintenance doses of hydroxycobalamin at two-monthly intervals. This is stated in NICE and BNF Guidelines but is unfortunately very often ignored and many patients are restricted to a maintenance regime of 3 monthly injections.




This is not nearly enough for many patients and is not based on clinical evidence but came about as a result of cost saving excercises! Oral cyanocobalamin is suitable only for the small number of people with proven dietary deficiency of vitamin B12. See this BMJ article. Injectable Cyanocobalamin is commonly used in the US and Canada and some European countries. This form converts to hydroxocobalamin and then to methylcobalamin and adenoslycobalamin in the body. It is a very stable form but is considered inferior to Hydroxocobalamin and it can worsen Leber's optic atrophy. It is also advised that smokers do not use cyanocobalamin.Please note: American patients may be able to access Hydroxocobalamin via prescription from both CVS and Walgreens pharmacies. Methlycobalamin (active B12) - It is available in injection form in the UK from private doctors or available over the counter in the form of; sublingual lozenges, capsules, sublingual sprays, nasal sprays and patches. It's important to note that these supplements do not help everyone.




Adenosylcobalamin - another form of active B12 this can also be used in injection form but more commonly as a sublingual lozenges, liquid drops or powder. Please note: we are all different and we may respond differently to the individual forms of B12. Some patients require a combination of forms. Click here for NICE Guidelines on treatment of B12 deficiency. It is wise to take a good vitamin B complex in addition to your B12 injection as all B vitamins need each other to work properly, supplementing one in isolation will cause an imbalance in others. If you are B12 deficient it is essential to have your folate (vitamin B9) and ferritin levels (iron storage) monitored in order to make sure you optimise your healing. Your doctor may not be aware of this! During early intensive B12 treatment potassium levels may fall, causing hypokalaemia, so please increase your intake of potassium rich foods. It is advisable to obtain copies of all your blood test results and to learn how to read them.

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