Int J Vitam Nutr Res. 2007 Jul;77(4):272-9.Wu TC1, Huang YC, Hsu SY, Wang YC, Yeh SL.Author information1Chest Clinic, Chung Shan Medical University Hospital, Taichung, Taiwan, ROC.AbstractThe purpose of this study was to determine whether vitamin E or vitamin C supplementation alters the DNA damage of whole blood white blood cells (WBC) in patients with chronic obstructive pulmonary disease (COPD). Thirty-five patients with stable COPD were recruited in this randomized and placebo-controlled study. Patients were randomly assigned to placebo (n = 8), 400 mg/day vitamin E (E400, n = 9), 200 mg/day vitamin E (E200, n = 9), or 250 mg/day vitamin C (C250, n = 9) for 12 weeks. The results showed that vitamin E or C supplementation did not significantly change the mean level of endogenous DNA breakages. Whereas, after 12 weeks of vitamin supplementation, the H2O2-induced DNA breakages were significantly suppressed by 45%, 59%, and 52%, respectively, in E400, E250 and C250 groups (p < 0.05). In addition, neither the level of thiobarbituric acid-reactive substances (TBARS) nor spirometric parameters were significantly changed after 12 weeks of supplementation.
In conclusion, vitamin E or C supplementation for 12 weeks may improve the resistance of DNA in whole blood WBC against oxidative challenge, although more research is needed to demonstrate the beneficial effect on slowing the decline of lung function in patients with COPD.PMID: 18271282 DOI: 10.1024/0300-9831.77.4.272 [Indexed for MEDLINE] Publication typesRandomized Controlled TrialResearch Support, Non-U.S. Gov'tMeSH termsAgedAged, 80 and overAscorbic Acid/administration & dosage*Ascorbic Acid/bloodComet AssayDNA DamageDietary SupplementsFemaleForced Expiratory Volume/drug effectsHumansMaleMiddle AgedOxidative Stress/drug effectsOxidative Stress/physiology*Pulmonary Disease, Chronic Obstructive/bloodPulmonary Disease, Chronic Obstructive/drug therapy*Pulmonary Disease, Chronic Obstructive/geneticsStatistics, NonparametricThiobarbituric Acid Reactive Substances/metabolismVital CapacityVitamin E/administration & dosage*Vitamin E/bloodSubstancesThiobarbituric Acid Reactive SubstancesVitamin EAscorbic AcidFull Text SourcesAtypon - PDFMedicalPulmonary Disease - Genetic AllianceChronic obstructive pulmonary disease - Genetic
AllianceCOPD - MedlinePlus Health InformationVitamin E - MedlinePlus Health InformationVitamin C - MedlinePlus Health InformationMiscellaneousSodium ascorbate - Hazardous Substances Data BankL-Ascorbic Acid - Hazardous Substances Data Bank Sold by Healthy Start + and Fulfilled by Amazon.DetailsLypo-Spheric Vitamin C , 0.2 fl oz. - 30 Packets | 1,000 mg Vitamin C Per Packet | ★ Save 20% when you purchase 2 Bottles of NanoNutrs's Liposomal Vitamin C ★ Enter code 2S6T24SU at checkout. Here's how (restrictions apply) ★ Purchase 4 bottles of NanoNutra's Liposomal Vitamin C and GET 1 of them FREE! ★ Enter code F578MUM7 at checkout. Dramatically Increase Absorption* Liposomalized vitamin C is absorbed much more efficiently than traditional delivery methods.* Our liposomes measure 197 nanometers allowing the Vitamin C to have maximum bioavailability for the body, resulting in more nutrient being used and less excreted via urine. A huge advance in both efficiency and effectiveness of supplemental nutrients!* What Are Nanotechnology Liposomes?
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