THIS IS A LIPOSOMAL COMPLEX. LIPOSOMES SURROUND THE METHYLCOBALAMIN TO ENSURE BIOAVAILABILITY. "Vitamin B12" refers to a group of compounds known as cobalamins. The most common form of vitamin B12 is called "cyanocobalamin." Vitamin B12 in the brain and central nervous system is only present as methylcobalamin, which is why methylcobalamin is the form of vitamin B12 that is called "neurologically active." Your liver has to t... Click here for more information 2 fluid ounces (59.1ml) Shake, spray under tongue or on inside of cheek. Hold for 20 seconds and swallow. There are approximately 88 sprays per bottle. Serving Size: 1 spray (0.7ml) % of Daily Value * Percent of Daily Value Not Established Other Ingredients: Purified water, glycerin, hydroxylated lecithin (from soybean oil), natural flavor, citric acid, potassium sorbate. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
is a leading online retailer of vitamins and nutritional supplements for people on the Autism spectrum. We carry Kirkman Labs, Thorne Research, Houston Nutraceuticals, Pure Encapsulations, Nordic Naturals, Metagenics, products like Liver Life, Lauricidin and Authia and many more supplements. , and we will look into adding it to our inventoryTri-Fortify (Liposomal glutathione & vitamin C) | This is an easily absorbed orange flavored Liposomal Glutathione with vitamin C.* Tri-Fortify™ Orange provides reduced L-glutathione, the major intracellular antioxidant essential for detoxification in the body,plus vitamin C, in an easy to absorb liposomal delivery system. The unique liposome structure allows it to combine effectively with the body's natural fluids and penetrate its protective membranes, bypassing the digestive system and directly entering the blood stream. By avoiding the process of digestion, nutrient absorption and utilization is much quicker and more complete.*
We have developed a new delivery system: a pleasant natural orange flavored gel that you squeeze onto a spoon and enjoy. No need to mix with juice. Tri-Fortify™ Orange effectively encases the glutathione, offering you a juicy orange taste profile unmatched by any other glutathione product.* It is known as the master antioxidant because it recycles other antioxidants, such as vitamins C and E.* GMO-free An integral part of our product quality orientation is to go beyond raw material supplier purity claims; our third party tests proved our product is GMO-free.* Bolsters Antioxidant Action Glutathione is a tri-peptide composed of the three amino acids: L-glutamic acid, L-cysteine and L-glycine. It is known as the master antioxidant because it recycles other antioxidants, such as vitamins C and E.* Tri-Fortify Orange (Liposomal glutathione & vitamin C) | Suggested UseAs a dietary supplement, gently squeeze the tube to fill 1 teaspoon (5 mL), and then swallow or use as directed by your health care professional.
Additional doses may be taken before other meals as well. Free of: milk, egg, fish, peanuts, crustacean shellfish, tree nuts, wheat, yeast, gluten, casein & sugar.Liposome (outer portion of delivery system) is partially derived from soy. FAQWhat is the source of the glycerin? It is vegetable derived Add a personal messageIt is vegetable derived.What is the source of the medium triglycerides? It is derived from coconut oil.What is the source of the orange flavor? It is from citrus fruit, no sugar added.If I have a soy sensitivity, do I need to worry?Generally, it is not an issue. We derive the liposomes from soy lecithin but we use only the lipids (i.e. phosphatidyl choline) as opposed to soy protein (the common allergen). However, we always recommend checking with your healthcare professional regarding your personal situationNo matter what clinical setting your medical or nutrition-focused practice is in, the antioxidant glutathione has undoubtedly been a topic of discussion.
Collectively, we understand that glutathione is the body’s main antioxidant and therefore the master detoxifier.[i] However, a simple statement of such, albeit grandiose, fails to capture the vast array of health conditions that glutathione may impact. Clinically, glutathione has importance in settings ranging from mental health to viral infections to heavy metal detoxification. It is worthy of a moment or two to highlight the research and clinical studies surrounding glutathione, and how the body’s glutathione status may impact various health conditions. Typical oral delivery of glutathione is greatly inhibited by breakdown in the stomach and minimally impacts intracellular levels. Thus, much research pertaining to glutathione involves the use of other substances which support intracellular glutathione levels.[ii] N-acetylcysteine (NAC) is one example, as this compound primarily has antioxidant benefits due to replenishing glutathione.[iii] Liposomal delivery systems protect glutathione from breakdown in the digestive system that otherwise prevents absorption of oral glutathione supplements.
Additionally, the phospholipid-encapsulated sphere which delivers glutathione into the cell simultaneously replenishes and nourishes the cell by providing phospholipids of which cellular membranes are comprised. In cell cultures, liposomal glutathione has been demonstrated to be 100 times more efficiency for intracellular delivery than non-liposomal glutathione.[iv] Increased oxidative stress and mitochondrial dysfunction may contribute to the development and clinical manifestation of autism.[v],[vi] Children on the autistic spectrum have been shown to have lower levels of glutathione, which may be caused by metabolic abnormalities and nutritional deficiencies, but also may further contribute to them.[vii] In addition to this, significantly lower levels of phospholipids have been reported in children with autism.[viii] Supplemental NAC and glutathione have been studied specifically in the setting of ASD, and have been shown to increase glutathione levels.[ix],[x] Utilization of glutathione in a liposomal format also provides the essential phospholipids which may be deficient and are necessary for mitochondrial and cellular repair.
Increased oxidative stress may contribute to attention deficit and mood disorders via numerous mechanisms.[xi],[xii] Therapies directed at supporting antioxidant levels such as NAC, vitamin C, and a pine back extract known as pycogenol have been studied in conditions of anxiety, depression, and/or attention deficit hyperactivity disorder (ADHD). [xiii],[xiv],[xv],[xvi] With therapies such as these, improvements have been seen clinically, possibly associated with their impact on glutathione levels.[xvii] Of course, this has thus become a topic of interest for those involved in development of pharmaceutical therapies, however substantial evidence exists for one to consider utilizing these nutritional substances, as well as glutathione, which already are readily available.In settings of autoimmune disease, there is an increased level of oxidative stress associated with immune activation and related inflammation. With this, glutathione levels become depleted. Glutathione is integral to the proper function of our immune system, especially for resistance to viruses.
[xix],[xx] Experimentally, a Th2 dominant (allergic state) is created with depletion of intracellular glutathione, and introduction of glutathione restores immune balance.[xxi] Given these relationships it is easy to see how supplemental glutathione may be supportive for balancing immune function, in addition to restoring levels which often are deficient in autoimmunity.Glutathione is necessary for cellular detoxification. The process of Phase II detoxification involves the binding of toxins with substances such as glutathione to create larger, inactive, water soluble molecules.[xxii] Toxins such as mercury are linked to glutathione, transported out of the cell, into the bile, and out of the body via stool. Glutathione is thus necessary to both protect the cell’s delicate chemical machinery and to transport toxins out. Because glutathione is utilized for the removal and elimination of mercury and other toxins from the cell, it also can become depleted in settings of toxicity.[xxiii] is a certified Naturopathic Doctor, graduating with honors from the National College of Natural Medicine (now the National University of Natural Medicine) in Portland, Oregon.
Dr. Decker also has graduate degrees in biomedical and mechanical engineering from the University of Wisconsin-Madison and University of Illinois at Urbana-Champaign respectfully. Dr. Decker sees patients at her office in Portland, OR, as well as remotely, with a focus on gastrointestinal disease, mood imbalances, eating disorders, autoimmune disease, chronic fatigue, and skin conditions. Dr. Decker also supports integrative medicine education as a writer and a contributor to various resources. Devasagayam TP, et al. Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India. View Abstract Exner R, et al. Therapeutic potential of glutathione. View Abstract Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. View Abstract Zeevalk GD, Bernard LP, Guilford FT. Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells.
Neurochem Res. 2010 Oct;35(10):1575-87. View Abstract James SJ, et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. View Full Paper Palmieri L, Persico AM. Mitochondrial dysfunction in autism spectrum disorders: cause or effect? View Abstract Omata Y, et al. Decreased zinc availability affects glutathione metabolism in neuronal cells and in the developing brain. Toxicol Sci. 2013 May;133(1):90-100. View Abstract El-Ansary AK, et al. Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia. Lipids Health Dis. 2011 Apr 22;10:63. View Full Paper Hardan AY, et al. A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. View Full Paper Kern JK, et al. A clinical trial of glutathione supplementation in autism spectrum disorders. View Full Paper Ross MA. Could oxidative stress be a factor in neurodevelopmental disorders? Prostaglandins Leukot Essent Fatty Acids.
View Abstract Moylan S, Berk M, Dean OM, et al. Oxidative & nitrosative stress in depression: why so much stress? Neurosci Biobehav Rev. 2014;45:46-62.View Abstract Dvořáková M, et al. The effect of polyphenolic extract from pine bark, Pycnogenol® on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD). View Abstract Trebatická J, et al. Treatment of ADHD with French maritime pine bark extract, Pycnogenol®. Euro Child & Adol Psych. 2006 Sep 1;15(6):329-35. View Abstract de Oliveira IJ, et al. Effects of Oral Vitamin C Supplementation on Anxiety in Students: A Double-Blind, Randomized, Placebo-Controlled Trial. Pak J Biol Sci. 2015 Jan;18(1):11-8. View Abstract Amr M, et al. Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study. Nutr J. 2013 Mar;12(1):1. View Full Paper Berk M, et al. Glutathione: a novel treatment target in psychiatry.
Trends Pharmacol Sci. 2008 Jul;29(7):346-51. View Abstract Perricone C, et al. Glutathione: a key player in autoimmunity. Autoimmun Rev. 2009 Jul;8(View Abstract Palamara AT, et al. Evidence for antiviral activity of glutathione: in vitro inhibition of herpes simplex virus type 1 replication. Antiviral Res. 1995 Jun;27(3):237-53. View Abstract Cai J, et al. Inhibition of influenza infection by glutathione. Free Radic Biol Med. 2003 Apr 1;34(7):928-36. View Abstract Peterson JD, et al. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3071-6. View Full Paper Zamek-Gliszczynski MJ, et al. Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and GSH metabolites. Eur J Pharm Sci. 2006 Apr;27(5):447-86. View Abstract Patrick L. Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity.