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  • Adding ~$171.2B to their market capitalization, Major pharma companies have outperformed their smaller counterparts in Q2 2021, according to an analysis by Evaluate Vantage.
  • Thanks to investor interest in its Alzheimer’s candidate, donanemab, Eli Lilly (NYSE:LLY) has posted the biggest gain among big pharma companies with a rise of nearly $59B in its market cap in the first half of the year.
  • AstraZeneca (NASDAQ:AZN), Sanofi (NASDAQ:SNY), and GlaxoSmithKline (NYSE:GSK) were also among the biggest gainers, according to the analysis.
  • Meanwhile, the renewed attention on Biogen (NASDAQ:BIIBafter FDA approval for its Alzheimer’s therapy Aduhelm was not enough for the company to outdo Moderna (NASDAQ:MRNA) in the category of big-cap players.
  • The analysis included data from a little over 700 pure-play drug developers with over $250M of market cap at the start of the year. The combined market cap of the group has risen $327B in Q2 2021 compared to $664B in the previous year's quarter.
  • As the graph from Evaluate indicates, the smaller drug companies as a group have lagged biggest players in Q2, marking a sharp contrast to their performance in Q1 2021.
  • However, adding $8B to the market cap this year, Intellia Therapeutics (NASDAQ:NTLA) was a notable gainer thanks to positive early-stage data for its gene-editing candidate TLA-2001 in rare disease, transthyretin amyloidosis ("ATTR").
  • According to the share performances in the first half, Eisai and Eli Lilly were among the top five gainers among large-cap pharmaceutical companies. 


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