J Appl Physiol (1985). Epub 2002 Dec 6.Stein TP1, Donaldson MR, Leskiw MJ, Schluter MD, Baggett DW, Boden G.Author information1Department of Surgery, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA. tpstein@umdnj.edu2U Med & Dent NJ, StratfordAbstractBed rest is associated with a loss of protein from the weight-bearing muscle. The objectives of this study are to determine whether increasing dietary branched-chain amino acids (BCAAs) during bed rest improves the anabolic response after bed rest. The study consisted of a 1-day ambulatory period, 14 days of bed rest, and a 4-day recovery period. During bed rest, dietary intake was supplemented with either 30 mmol/day each of glycine, serine, and alanine (group 1) or with 30 mmol/day each of the three BCAAs (group 2). Whole body protein synthesis was determined with U-(15)N-labeled amino acids, muscle, and selected plasma protein synthesis with l-[(2)H(5)]phenylalanine. Total glucose production and gluconeogenesis from alanine were determined with l-[U-(13)C(3)]alanine and [6,6-(2)H(2)]glucose.
During bed rest, nitrogen (N) retention was greater with BCAA feeding (56 +/- 6 vs. 26 +/- 12 mg N. kg(-1). day(-1), P < 0.05). There was no effect of BCAA supplementation on either whole body, muscle, or plasma protein synthesis or the rate of 3-MeH excretion. Muscle tissue free amino acid concentrations were increased during bed rest with BCAA (0.214 +/- 0.066 vs. 0.088 +/- 0.12 nmol/mg protein, P < 0.05). Total glucose production and gluconeogenesis from alanine were unchanged with bed rest but were significantly reduced (P < 0.05) with the BCAA group in the recovery phase. In conclusion, the improved N retention during bed rest is due, at least in part, to accretion of amino acids in the tissue free amino acid pools. The amount accreted is not enough to impact protein kinetics in the recovery phase but does improve N retention by providing additional essential amino acids in the early recovery phase.PMID: 12471043 DOI: 10.1152/japplphysiol.00481.2002 [Indexed for MEDLINE] Publication typesResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.MeSH termsAdultAlanine/metabolismAmino Acids/administration & dosageAmino Acids, Branched-Chain/administration & dosageAmino Acids, Branched-Chain/therapeutic use*Bed Rest*Blood Proteins/biosynthesisDietDietary Supplements*GluconeogenesisHumansLiver/metabolismMaleMuscle Proteins/biosynthesisMuscle Proteins/metabolismNitrogen/metabolismProteins/metabolismSubstancesAmino AcidsAmino Acids, Branched-ChainBlood ProteinsMuscle ProteinsProteinsNitrogenAlanineGrant support2M01-RR-349/RR/NCRR NIH HHS/United StatesR01-14098/PHS HHS/United StatesR01-DK-58895/DK/NIDDK NIH HHS/United StatesFull Text SourcesHighWireMedicalClinicalTrials.govDietary Supplements - MedlinePlus Health
InformationMiscellaneous(L)-ALANINE - Hazardous Substances Data BankNitrogen, Elemental - Hazardous Substances Data BankCan we help you find something? We're sorry, but we couldn't find the page you tried.One of the links below may help. Or you can visit WebMD's Home Page. To check possible conditions. First Aid & Emergencies Find out what to do in case of an emergency Create a plan, log your food & fitness, and track your way to Serving Size: 1 scoop (24g)Servings Per Container: 25 % Daily Value * Calories from Fat 0g Vitamin A (as beta carotene) 5000 IU Vitamin C (as ascorbic acid) 100mg Thiamin (as thiamin hydrochloride) 1.5mg Riboflavin (as riboflavin USP) 1.7mg Vitamin B6 (as pydridoxine hydrochloride) 2mg Vitamin B12 (as cyanocobalamin) 6mcg Pantothenic Acid (as calcium d-pantothenate) 10mg Proprietary Anabolic Amino Complex 9.75g L-Glutamine, L-Leucine, L-Valine, L-Tyrosine, L-Isoleucine, L-Glycine
Other Ingredients: Maltodextrin, citric acid, lecithin, natural flavor, sucralose. Contains: Soy** Daily Value not established.* Daily Values are based on a 2,000 Calorie per day diet. ProSourceMyo-SurgeThe Original Pre-Workout Powerhouse Most athletes recognize the importance of supplementing with a top-quality post-workout like MyoZene or After Mass following exercise. Many do not know, however, that fueling up on essential BCAAs and glutamine before working out could be as important to the mass-building equation. This fact is supported in at least one key study indicating that pre-workout supplementation may be equal to post-workout supplementation when it comes to enhancing protein synthesis. It’s research like this that helped impel the ProSource product development team to create this simple, yet rock-solid formula in order to give bodybuilders that instrumental nutrition for maximum muscle support before and during an intense workout.If you're not getting the mass-building results you want from your workout regimen, Myo-Surge pre-workout formula may be the solution.
Myo-Surge gives your glutamine levels a powerful boost while providing the essential branched chain amino acids (L-Leucine, L-Isoleucine, L-Valine) for maximum protein synthesis during and after exercise. Most bodybuilders know just how crucial glutamine is to helping significantly reduce muscle breakdown, increase protein synthesis, enhance nitrogen retention and promote cell volumization. BCAAs are also at the forefront of providing muscle sparing, energizing, growth promoting benefits. Working together, glutamine and BCAAs provides an explosive one-two punch every athlete needs to load up on before working out. In other words, Myo-Surge creates an optimum muscular environment for an intense and productive workout!al. Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise. Am J Physiol Endocrinol Metab. De Palo EF, et. al. Plasma lactate, GH and GH-binding protein levels in exercise following BCAA supplementation in athletes. al. Branched chain amino acid supplementation during bed rest: effect on recovery.