Vancomycin trough guidelines

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Abstract. Practice guidelines for therapeutic monitoring of vancomycin treatment for Staphylococcus aureus infection in adult patients were reviewed by an expe. Trough serum vancomycin concentrations are the most accurate and practical method of monitoring the effectiveness of vancomycin. Trough serum 1 Jan 2009 therapeutic levels. Continuous infu- sion regimens are unlikely to sub- stantially improve patient outcome when compared with intermittent dosing. (Level of evidence = II, grade of recommendation = A.) Therapeutic vancomycin drug monitoring. Peak versus trough concentra- tions. Over the years, serum Guidelines for Vancomycin Dosing and Determination of Trough Levels in. Adult Patients. IV. Vancomycin Levels. Vancomycin levels are NOT needed in patients with stable renal function who are on standard doses of vancomycin AND are on therapy for less than 5 days. Vancomycin peak levels are rarely, if ever, indicated Abstract. Vancomycin is a glycopeptideantibiotic that has been in clinical use for nearly 50 years as a penicillin alternative to treat penicillinase-producing strains of Staphylococcus aureus. It is one of the most widely used antibiotics in the United States for the treatment of serious gram-positive infections involving 18 Jun 2010 The recommendations state that vancomycin dosing should be based on target serum trough levels obtained after the third dose, and subsequent doses should be determined according to vancomycin levels and changes in renal function. The dose chosen needs to be guided by the clinical picture and age of patient, and adjusted according to trough levels. Neonates. IV: Loading dose of 15 mg/kg then. Preterm: 10 mg/kg/dose 24 hrly. Term: Week 1 of life: 10 mg/kg/dose 12 hrly. Week 2-4 of life: 10 mg/kg/dose 8 hrly. Severe infections: 15 mg/kg/dose. Obtain trough levels prior to the 4th dose of a new regimen (prior to the 3rd dose for patients with dosing intervals. > 24 hours). - Trough levels should be obtained within 30 minutes before the next scheduled dose. - Repeat trough levels weekly with stable dosing AND with any significant changes in renal function. 7 Feb 2014 Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough levels is 10-20 µg/mL (15-20 µg/mL for complicated infections). UCSFMC Adult Vancomycin Dosing and Monitoring Recommendations. Print; PDF. Print PDF. Vancomycin has demonstrated dose-response and dose-toxicity relationships with a relatively narrow therapeutic index. Thus, careful dosing and monitoring is warranted.