Oecd guidelines 408

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22 Jun 2011 This guidance further develops the general procedure set. 20 out in the OECD Guideline for the Testing of Chemicals – Repeated Dose 90-day Oral Toxicity Study. 21 in Rodents (OECD TG 408), and provides specific advice for performing and reporting experiments. 22 carried out with whole food/feed. 23. OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress. The original guideline 408 was adopted in 1981. In 1998 a revised version was adopted, to obtain additional information from the animals used in the study, based on the outcome of an OECD Consultation Meeting of This Test Guideline is intended primarily for use with rodents (rat preferably). At least 20 animals (10 female and 10 male) should be used for each test group. Three concentrations, at least, should be used. The test compound is administered by gavage or via the diet or drinking water. A limit test may be performed if no 3 Oct 2008 2. In 1998, the OECD initiated a high-priority activity, to revise existing Test Guidelines and to develop new Test Guidelines for the screening and testing of potential endocrine disruptors (8). One element of the activity was to update the existing OECD guideline for “repeated dose 28-day oral toxicity study in 16 Jun 2004 OECD. 1981. Test Guideline 452. Chronic Toxicity Studies. In: OECD. Guidelines for the testing of chemicals Organization for Economic. Cooperation & Development, Paris. 2. OECD. 1998. Test Guideline 408. Repeated Dose 90-day Oral. Toxicity Study in Rodents. In: OECD Guidelines for the testing of. 7 Dec 2011 Following a request from the European Commission, the Scientific Committee developed principles and guidance for the establishment of protocols for 90-day whole food/feed studies in rodents. The guidance complements the OECD Test guideline 408 and provides specific advice for performing and This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The determination of sub-ch.