Monkey Mouse Sex Mp3
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Subject: 1 selected item: 17125407 - PubMed
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1 Nerviano Medical Sciences, Preclinical Development, Viale Pasteur 10, Nerviano (MI), Italy. marcella.martignoni@nervianoms.com
Marcella Martignoni et al. Expert Opin Drug Metab Toxicol. 2006 Dec.
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1 Nerviano Medical Sciences, Preclinical Development, Viale Pasteur 10, Nerviano (MI), Italy. marcella.martignoni@nervianoms.com
Animal models are commonly used in the preclinical development of new drugs to predict the metabolic behaviour of new compounds in humans. It is, however, important to realise that humans differ from animals with regards to isoform composition, expression and catalytic activities of drug-metabolising enzymes. In this review the authors describe similarities and differences in this respect among the different species, including man. This may be helpful for drug researchers to choose the most relevant animal species in which the metabolism of a compound can be studied for extrapolating the results to humans. The authors focus on CYPs, which are the main enzymes involved in numerous oxidative reactions and often play a critical role in the metabolism and pharmacokinetics of xenobiotics. In addition, induction and inhibition of CYPs are compared among species. The authors conclude that CYP2E1 shows no large differences between species, and extrapolation between species appears to hold quite well. In contrast, the species-specific isoforms of CYP1A, -2C, -2D and -3A show appreciable interspecies differences in terms of catalytic activity and some caution should be applied when extrapolating metabolism data from animal models to humans.
Gómez-Lechón MJ, Donato T, Ponsoda X, Castell JV. Gómez-Lechón MJ, et al. Altern Lab Anim. 2003 May-Jun;31(3):257-65. doi: 10.1177/026119290303100307. Altern Lab Anim. 2003. PMID: 15612868
Thelen K, Dressman JB. Thelen K, et al. J Pharm Pharmacol. 2009 May;61(5):541-58. doi: 10.1211/jpp/61.05.0002. J Pharm Pharmacol. 2009. PMID: 19405992 Review.
Zuber R, Anzenbacherová E, Anzenbacher P. Zuber R, et al. J Cell Mol Med. 2002 Apr-Jun;6(2):189-98. doi: 10.1111/j.1582-4934.2002.tb00186.x. J Cell Mol Med. 2002. PMID: 12169204 Free PMC article. Review.
Strolin Benedetti M, Whomsley R, Baltes E. Strolin Benedetti M, et al. Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):895-921. doi: 10.1517/17425255.2.6.895. Expert Opin Drug Metab Toxicol. 2006. PMID: 17125408 Review.
Singh SS. Singh SS. Curr Drug Metab. 2006 Feb;7(2):165-82. doi: 10.2174/138920006775541552. Curr Drug Metab. 2006. PMID: 16472106 Review.
Alehaideb Z, Alatar G, Nehdi A, Albaz A, Al-Eidi H, Almutairi M, Hawsa E, Alshuail N, Matou-Nasri S. Alehaideb Z, et al. Saudi Pharm J. 2021 May;29(5):361-368. doi: 10.1016/j.jsps.2021.03.002. Epub 2021 Apr 1. Saudi Pharm J. 2021. PMID: 34135662 Free PMC article.
Johanson SM, Ropstad E, Østby GC, Aleksandersen M, Zamaratskaia G, Boge GS, Halsne R, Trangerud C, Lyche JL, Berntsen HF, Zimmer KE, Verhaegen S. Johanson SM, et al. PLoS One. 2021 Jun 10;16(6):e0252954. doi: 10.1371/journal.pone.0252954. eCollection 2021. PLoS One. 2021. PMID: 34111182 Free PMC article.
Segatto NV, Bender CB, Seixas FK, Schachtschneider K, Schook L, Robertson N, Qazi A, Carlino M, Jordan L, Bolt C, Collares T. Segatto NV, et al. Front Mol Biosci. 2021 May 17;8:681044. doi: 10.3389/fmolb.2021.681044. eCollection 2021. Front Mol Biosci. 2021. PMID: 34079821 Free PMC article.
Gerner B, Scherf-Clavel O. Gerner B, et al. Pharmaceutics. 2021 May 22;13(6):778. doi: 10.3390/pharmaceutics13060778. Pharmaceutics. 2021. PMID: 34067429 Free PMC article.
Darakjian L, Deodhar M, Turgeon J, Michaud V. Darakjian L, et al. Int J Mol Sci. 2021 May 7;22(9):4967. doi: 10.3390/ijms22094967. Int J Mol Sci. 2021. PMID: 34067027 Free PMC article. Review.
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YouTube Has a Vile Monkey Torture Community That Needs Nuking
YouTube has been hosting a violent monkey hate group for years. The shocking channel encourages cruelty and violence against baby monkeys.
As the world's biggest video-hosting platform, YouTube has to pick up the pace in clearing out the trash. | Source: Shutterstock.com
YouTube has irked many creators that think the platform is too heavy-handed with censorship. But it hasn’t bothered to censor a monkey torture community that’s been active for at least three years.
(Warning: the YouTube content at the link is disturbing.)
The name of the channel is “killbabymonkeys.” It doesn’t have any video uploads, but it creates playlists of other videos featuring injured, abused, or dying monkeys.
The channel’s creator obviously spent a lot of time gathering this material from far and wide on YouTube. The playlists have shocking and abusive titles like:
dead monkeys
Wounded monkeys
Rotten little vermin make you wanna kick them
Don’t you wish you could step on it?
On many of the videos, the channel’s subscribers have left comments encouraging violence against monkeys. Many of the videos are on non-English-speaking users’ channels. So they may not realize what the monkey cruelty group’s English language comments are saying.
Things you see when you don’t have your gun with you
God what I could do with a baseball bat here
God I could kick that rotten little creature
There’s nothing as ugly and useless as a baby monkey.
What is this monkey torture community doing on YouTube?
Social media communities have generated a lot of controversy in recent years over creators mistreating their pets on video. A popular Twitch streamer has fed vodka to her cats and thrown them while streaming. Last year a YouTube creator was investigated by the LA police department for animal cruelty after pranking her dog for a video.
These cases are controversial, but difficult to clearly define as animal cruelty. But there’s no gray area with this monkey cruelty community. They’re blatantly glorifying extreme animal cruelty for sport. It’s impossible to tell if the community is trolling or serious, but either way they are psychopaths. And what they’re doing could lead to real world harm to monkeys or other animals if left unchecked by the YouTube.
It doesn’t stop at monkeys either. YouTube has a number of videos (disturbing video at the link) depicting rats and mice dying in mouse traps. These aren’t legitimate videos helping people with pest control. They’re just gratuitous footage of animals slowly dying. They have sadistic descriptions like:
I have compiled this video for your satisfaction.
And some of the commenters say they are laughing at the animals. It’s hard to believe videos like this, and the violent monkey hate channel have been on YouTube for years, when educators, journalists, and activists are getting demonetized and censored.
Last modified: September 23, 2020 1:37 PM
W. E. Messamore: Markets Contributor for CCN living in Nashville, Tennessee. Bachelor of Business Administration from Belmont University in 2009 (majored in Entrepreneurship). Organized Senator Rand Paul's first and second online fundraisers in 2009. Roving editor for the Independent Voter Network since 2013. Email me | Link up with me on LinkedIn | Follow Me on Twitter (followed by: fmr Rep. Ron Paul (R-TX), Sen. Rand Paul (R-KY), fmr NM Gov. Gary Johnson, and Rep. Thomas Massie (R-KY))
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Monkey Mouse Sex Mp3
