Метилфенидат — WiKi

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Метилфенидат

Метилфенидат — WiKi

Трип репорт мефедрон

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Methylphenidate is the parent compound of the substituted phenidates , a family of compounds that includes ethylphenidate , isopropylphenidate , and others. It acts primarily by enhancing the activity of the neurotransmitters dopamine and norepinephrine in the brain. Methylphenidate was first licensed by the U. Methylphenidate is approved for treatment of attention-deficit hyperactivity disorder ADHD and narcolepsy. It is often used by students with or without ADHD to enhance their mental abilities, improve their concentration, and help them study. Methylphenidate is a synthetic molecule of the substituted phenethylamine and substituted phenidate classes. It contains a phenethylamine core featuring a phenyl ring bound to an amino -NH 2 group through an ethyl chain. Additionally, it contains a methyl acetate bound to R 2 or its structure. Methylphenidate is a chiral compound, presumably produced as a racemic mixture. It has an enantiopure also sold as a pharmaceutical; the dextrorotary enantiopure is known as ' dexmethylphenidate ' and is commonly sold as Focalin and Focalin XR. Methylphenidate primarily acts as a dopamine - norepinephrine reuptake inhibitor. It is most active at modulating levels of dopamine and, to a lesser extent, norepinephrine. While both amphetamine and methylphenidate are dopaminergic, it should be noted that their methods of action are somewhat distinct. Specifically, methylphenidate is a dopamine reuptake inhibitor while amphetamine is both a releasing agent and reuptake inhibitor of dopamine and norepinephrine. Each of these drugs have a corresponding effect on norepinephrine which are weaker than their effects on dopamine. Disclaimer: The effects listed below are cited from the Subjective Effect Index SEI , which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death. Anecdotal reports which describe the effects of this compound within our experience index include:. It is strongly recommended that one use harm reduction practices when using this substance. In terms of its tolerance, methylphenidate can be used multiple days in a row for extended periods of time and is often prescribed to be used in this way. Tolerance to many of the effects of methyphenidate develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. As with other stimulants , the chronic use of methylphenidate can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Methylphenidate has some potential for abuse due to its action on dopamine transporters. Methylphenidate, like other stimulants , increases dopamine levels in the brain. However, at therapeutic doses this increase is slow and thus euphoria only rarely occurs even when it is administered intravenously. The abuse potential is increased when methylphenidate is crushed and insufflated snorted or injected. It should be noted that due to the fillers in the pill, however, that this can be harmful to the nasal cavities. The primary source of methylphenidate for abuse is the diversion from legitimate prescriptions rather than illicit synthesis. Those who use methylphenidate medicinally generally take it orally as instructed while intranasal and intravenous are the preferred means for recreational use. Chronic abuse of methylphenidate can potentially lead to psychosis. Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations although it cannot be guaranteed to include all of them. Independent research e. Google , DuckDuckGo should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit. It is a widespread myth that methylphenidate could lead to false-positives for amphetamin in drug screenings. However, there was found no immunoassay cross reactivity in laboratory study. Summary sheet: Methylphenidate Methylphenidate. Physical effects. Cognitive effects. After effects. Main article: Stimulant psychosis. Running on Ritalin. ISBN Cardiovascular safety of methylphenidate should also be considered in adults. Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects. Human Psychopharmacology: Clinical and Experimental, 19 3 , Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5 2 , Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95 4 , Archived from the original PDF on 31 August August Retrieved 2 March Office of Parliamentary Counsel. Retrieved December 24, Department of Justice. Archived from the original on April 16, Journal of Analytical Toxicology. Categories : All articles with unsourced statements Articles with unsourced statements Psychoactive substance Piperidine Phenidate Stimulant. Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Community Network YouTube Good vibes. Summary sheet: Methylphenidate.