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Preparation of Aliphatic Amines by the Leuckart Reaction. Lin Yang, Rongji Dai, Wei Liu and Yulin Deng, School of Life Science and Technology,. Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing, China. The in situ reductive amination of carbonyl compounds has been an important part. The formation of saturated amines from carbonyl compounds by treatment with ammonium formats or fonnamide or mixtures of formamide and formic acid is known as the Leuckart reaction. The reaction was dis- covered in 1885 by Leuckart.l At the beginning of this century, the reaction was further studied by Wallach and. not permit one to exclude either of the mechanisms shown in equa- tions 1 and 2 on p. 304; both mechanisms may be operative under appropriate experimental conditions. The reaction between benzophenone and formamide is catalyzed by ammonium formate, magnesium chloride, or ammonium sulfate, and it has been The Leuckart reaction is the chemical reaction that converts aldehydes or ketones to amines by reductive amination in the presence of heat. The reaction, named after Rudolf Leuckart, proceeds via two mechanisms: one using ammonium formate and the other using formamide as the reducing agent. It requires high The preparation of N-benzhydryl formamide from benzophenone by the Leuckart reaction has been reported by Leuckart and Bach2 using am- monium formate. The compound has been pre- pared in this la&oratory by the general procedure of Ingersoll” with good results. Since Ingersol14 stated that somewhat higher THE MECHANISM OF THE. LEUCKART REACTION. By. DAVID C. YOUNG, IR. A DISSERTATION PRESENTED TO THE GRADUATE COUNCIL OF. THE UNIVERSITY OF FLORIDA. IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE. DEGREE OF DOCTOR OF PHILOSOPHY. UNIVERSITY OF FLORIDA. Abstract: A Cp*Rh(III) complex catalyzes reductive ami- nation of ketones using HCOONH4 at 50-70 °C to give the corresponding primary amines in high yields. The reaction is clean and operationally simple and proceeds at a lower temperature and with higher chemoselectivity than the original Leuckart-Wallach reaction. The Leuckart reaction is perhaps best defined as a process for the reductive amination of aldehydes or ketones by formamide, ammonium formate, or formic acid with formamide. The reaction is carried out by heating a mixture of the carbonyl compound and the amide or its derivative. Primary and secondary. Sep 19, 2017 Effect of Formamide in the Leuckart Reaction. Article (PDF Available) in Acta Chemica Scandinavica 53(1):76-78 · January 1999 with 90 Reads. DOI: 10.3891/acta.chem.scand.53-0076. Cite this publication. Tore Lejon at UiT The Arctic University of Norway · Tore Lejon. 31.42; UiT The Arctic University of The Leuckart reaction, a reductive amination procedure of carbonyl compounds, is roughly one century old I and during this period, the harsh experimental conditions required to carry out the reaction have remained essentially unchanged. Particularly, the need for high reaction temperatures (=240°C), sealed containers