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A person may experience the intoxicating effects of MDMA within 45 minutes or so after taking a single dose. Those effects include an enhanced sense of well-being, 28,53 increased extroversion, 27,53 emotional warmth, empathy toward others, 54 and a willingness to discuss emotionally-charged memories. However, MDMA can also cause a number of acute adverse health effects. For example, while fatal overdoses on MDMA are rare, they can potentially be life threatening—with symptoms including high blood pressure hypertension , faintness, 8,56 panic attacks, 57 and in severe cases, a loss of consciousness and seizures. This can lead to one of the most significant, although rare, acute adverse effects—a marked rise in body temperature hyperthermia. However, this could increase the risk of electrolyte imbalance or brain swelling because MDMA causes the body to retain water. MDMA can also produce other adverse health effects, including involuntary jaw clenching, 53 lack of appetite, 28,53 mild detachment from oneself depersonalization , illogical or disorganized thoughts, restless legs, 28 nausea, 56,57,66 hot flashes or chills, 8,56 headache, sweating, 8,57 and muscle or joint stiffness. This emphasizes the potential dangers of performing complex or skilled activities, such as driving a car, while under the influence of this drug. Recreational use of MDMA is often characterized by repeated drug taking over a number of days binges , followed by periods of no drug taking. In one animal study, this pattern of use produced irregular heartbeat arrhythmia and heart damage. Sleep disturbances, lack of appetite, concentration difficulties, depression, 79 heart disease, 81,82 and impulsivity 83 have been associated with regular use of MDMA. In addition, heavy MDMA use over a 2-year period of time is associated with decreased cognitive function. More research is needed to understand the specific effects of regular MDMA use. Various studies have found that MDMA use is associated with risky sexual behaviors. For example, both males and females who use MDMA are more likely than alcohol-drinking controls to engage in risky sexual behaviors e. People who use heavily are also more likely to have been tested for HIV, though they believe they are at low risk for contracting the disease. National Institute on Drug Abuse website. September 26, This series of reports simplifies the science of research findings for the educated lay public, legislators, educational groups, and practitioners. The series reports on research findings of national interest. Skip to main content. What are the effects of MDMA? Acute Effects A person may experience the intoxicating effects of MDMA within 45 minutes or so after taking a single dose. Prev Index Next. What is the history of MDMA? Who is using MDMA? Can MDMA use during pregnancy harm the baby? How can MDMA use be prevented? How are MDMA use disorders treated? Ordering Publications Call or:. Cite this article. Featured Publications. Opioids: Facts Parents Need to Know. Opioid Facts for Teens.
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Methylenedioxymethamphetamine MDMA , better known as ecstasy or 'molly,' is a synthetic drug derived from amphetamine. However, as with any street drug, using MDMA also comes with notable risks. Ecstasy became popular during the s and s when it became a mainstream street drug associated with music festivals, raves, concerts, and clubs. BZP benzylpiperazine is now also being used as a 'legal form' of ecstasy. Drug Class: Ecstasy acts as both a stimulant and a hallucinogen. Common Side Effects: Some of the more common side effects of ecstasy include nausea, blurred vision, rapid breathing, increased heart rate, and involuntary teeth clenching. Ecstasy usually comes in a small, colored tablet that may have a brand logo or cartoon character stamped on it. It can also come in a capsule, liquid, or powder form. It usually has a bitter taste. MDMA pills frequently include other dangerous substances such as meth, cocaine, ketamine , or LSD, so it is difficult to know exactly what the tablets contain. MDMA works by boosting the activity of three brain chemicals called neurotransmitters: dopamine, serotonin, and norepinephrine. People who use ecstasy report feelings of euphoria, warmth, openness, and clarity as well as heightened sensations of touch, sound, and smell. Some people report feeling energetic and uninhibited. The effects typically begin within 30 minutes of taking the drug and last for three to six hours. In nearly a quarter of the samples tested, researchers were not even able to determine what substances the pills contained. The researchers suggested that offering on-site pill-testing stations at concerts and other social events where ecstasy is commonly consumed might reduce risks to users. Another danger is that potential interactions can occur between the ingredients as well as any other substances people use with MDMA such as alcohol, medications, or other drugs. The drug is often taken at social events such as raves and concerts due to its energizing effects. The problem is that it is impossible to know if these effects are due to the drug itself or the presence of other stimulants that ecstasy is often mixed with. MDMA was originally developed in as a pharmaceutical compound to help synthesize medications to control bleeding. During the s and s, for example, a small number of psychiatrists started giving MDMA to their patients as a way to facilitate psychotherapy. Ecstasy can produce the positive effects that people seek in as little as 15 minutes, but it can also cause a variety of negative effects. Hyperthermia: MDMA is often used during high-energy activity, such as dancing at clubs or music festivals. Thankfully, hyperthermia is rare, but it needs to be treated immediately because it can quickly lead to muscle breakdown, which can then result in kidney failure and heart disturbances. Your risk of engaging in unsafe drug use, such as injecting yourself with a dirty needle, is also higher. Ecstasy use can also lead to an accidental overdose. Using other drugs or alcohol with MDMA increases this risk. You should contact emergency services immediately if you suspect someone has overdosed or is having a negative reaction to ecstasy. One common ecstasy myth is that it is a safe 'party' drug with few long-term effects. However, many people still feel anxious, restless, irritable, and sad up to a week after using MDMA. People also sometimes have memory and concentration problems and experience lack of pleasure from sex. Similarly, increased anxiety, impulsive behavior, aggression, sleep issues, loss of appetite, and heart disease have been observed in regular MDMA users. Some of them may be related to other drugs that people often use along with MDMA. These effects may also be attributed to the other often unknown ingredients found in MDMA. Some research , as well as anecdotal reports, suggest that people do develop a tolerance to ecstasy after repeated use. When tolerance occurs, people must increase the amount of the substance they take in order to feel the same effects that they initially experienced. Research also suggests that ecstasy does have some dependence potential. Dependence means that people have to keep taking the drug in order to avoid experiencing the negative effects of withdrawal. In the case of ecstasy, the risks of physical dependence seem to be less likely than those of psychological dependence. How long ecstasy lasts and stays in your system depends on a number of factors including metabolism, body mass, hydration levels, and food intake. The effects of the drug usually start within 30 minutes of consumption and the 'high' lasts from three to six hours. MDMA is usually detectable by urine drug tests for one to four days after taking the drug. The detection window can also be influenced by how much of the drug was taken. Animal studies have found that animals will self-administer the drug, but the research suggests that this effect is less pronounced than it is with other addictive drugs such as cocaine. When you use MDMA, your brain releases a flood of neurotransmitters that bring on the uplifting effects of the drug. This can lead to withdrawal symptoms like:. These symptoms of withdrawal can sometimes cause people to continue using in order to avoid feeling these unpleasant effects. This will help you learn how to stop using MDMA, avoid substituting it with other drugs, and improve your mental health. Treatment options usually focus on behavioral therapies that help people change the underlying thought patterns that contribute to substance use. If you are concerned about your ecstasy use, talk to your doctor about your treatment options or call the toll-free SAMHSA national hotline at to locate treatment services in your area. Learn the best ways to manage stress and negativity in your life. Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine. ACS Chem Neurosci. Meyer JS. Subst Abuse Rehabil. Published Nov PubChem Compound Database. National Center for Biotechnology Information. Published MDMA adulterants by product name and the impact of harm-reduction services at raves. J Psychopharmacol Oxford. Althobaiti YS, Sari Y. J Addict Res Ther. Byock I. Taking Psychedelics Seriously. J Palliat Med. Parrott AC. Drug Alcohol Depend. Asser A, Taba P. Psychostimulants and movement disorders. Front Neurol. Published Apr National Institute on Drug Abuse. Published September 26, Cognitive behavioral therapy for substance use disorders. Psychiatr Clin North Am. National Institutes of Health. More in Addiction. What Does Ecstasy Do? Common Side Effects. Signs of Use. How to Get Help. View All. How to Recognize Ecstasy Ecstasy usually comes in a small, colored tablet that may have a brand logo or cartoon character stamped on it. Positive Effects Mental stimulation An increased sense of well-being Emotional warmth Empathy Feeling less reserved Decreased anxiety Increased energy Enhanced sensory perception. Some of the common signs that someone might be using ecstasy include:. The presence of drug paraphernalia e. Overdose Signs to Watch For High blood pressure Feeling faint Panic attacks Loss of consciousness Seizures You should contact emergency services immediately if you suspect someone has overdosed or is having a negative reaction to ecstasy. Was this page helpful? Thanks for your feedback! Sign Up. What are your concerns? Article Sources. Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial policy to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. S PubChem Compound Database. Continue Reading. Related Articles. Ecstasy Drug Information and History. Health Effects of Illegal Drugs. Verywell Mind uses cookies to provide you with a great user experience. By using Verywell Mind, you accept our.
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