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ЭТИЛФЕНИДАТ ПлоцкКак это было, зачем, что потом и что теперь: Кратко о себе: с детства повышенная нервная возбудимость, окр (проявляющееся в потребности делать некоторые жесты по несколько раз, вроде выключения света, закрытия двери до 'идеального щелчка', разглаживания одежды на стуле). Как заверил.
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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. It is not a recommendation and should be verified with other sources for accuracy. Ethylphenidate also known as EPH is a novel stimulant substance of the phenidate class that produces traditional stimulant effects when administered. It is a closely related analog of methylphenidate brand names Ritalin, Concerta. The two substances have very similar pharmacological mechanisms but discernible differences in their subjective effects with ethylphenidate often considered to be recreational. Ethylphenidate is most commonly distributed as a research chemical by online vendors, due to its grey-area legal status in certain countries. Ethylphenidate is a synthetic molecule of the substituted phenethylamine and substituted phenidate classes. It contains a phenethylamine core featuring a phenyl ring bound to an amino -NH2 group through an ethyl chain. Additionally, it contains an ethyl acetate bound to R 2 or its structure. Ethylphenidate is structurally differed to methylphenidate by elongation of the carbon chain. Ethyl- regards the side chain of two carbon atoms, phen- indicates the phenyl ring, id- is contracted from a piperidine ring, and -ate indicates the acetate group containing the oxygens. Ethylphenidate is a chiral compound, presumably produced as a racemic mixture. Ethylphenidate acts as both a dopamine reuptake inhibitor and norepinephrine reuptake inhibitor , meaning it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects. It has been found that ethylphenidate is more selective to the dopamine transporter DAT than methylphenidate , having approximately the same efficacy as the parent compound, \\\\\\\\\[1\\\\\\\\\] but with significantly less activity on the norepinephrine transporter NET. Figures for both the racemic and the dextrorotary enantiomers are given: \\\\\\\\\[4\\\\\\\\\]. Ethylphenidate can be formed within the body in the liver , when alcohol and methylphenidate are co-ingested. The general headspace of ethylphenidate is described by many as one of extreme mental stimulation, increased focus, and powerful euphoria. It contains a large number of typical stimulant cognitive effects. Although negative side effects are usually mild at low to moderate dosages, they become increasingly likely to manifest themselves with higher amounts or extended usage. This particularly holds true during the offset of the experience. Disclaimer: The effects listed below cite the Subjective Effect Index SEI , a literature which relies on collected anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. Likewise, adverse effects become much more likely with higher doses and may include serious injury or death. There are currently anecdotal reports which describe the effects of this compound within our experience index. The toxicity and long-term health effects of recreational ethylphenidate use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because ethylphenidate has a very limited history of human usage. Anecdotal evidence from people who have tried ethylphenidate within the community suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly but nothing can be completely guaranteed. It is worth noting that ethylphenidate crystals are particularly abrasive and somewhat caustic to mucous membranes. Careless use will deteriorate the chosen routes of administration so it is important to practice routine maintenance such as soaking the sinus cavity with water prior to and following insufflation. It will also irritate lung tissue if inhaled, resulting in the production of phlegm and an irritated cough. It is strongly recommended that one use harm reduction practices when using this substance. As with other stimulants , the chronic use of ethylphenidate can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Tolerance to many of the effects of ethylphenidate develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline in the absence of further consumption. Abuse of compounds within the stimulant class at high dosages for prolonged periods of time can potentially result in a stimulant psychosis that may present with a variety of symptoms e. Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations although it cannot be guaranteed to include all of them. Independent research e. Google , DuckDuckGo should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit. Ethylphenidate is not controlled internationally and remains easily accessible through online research chemical vendors. It is, however, illegal or at least potentially illegal within certain jurisdictions, each of which are listed below:. Summary sheet: Ethylphenidate Ethylphenidate. Physical effects. Cognitive effects. After effects. Main article: Stimulant psychosis. New York: Oxford University Press. ISBN Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5 2 , Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95 4 , Public Works and Government Services Canada. Archived from the original on June 13, Retrieved December 24, Retrieved December 23, Bundesanzeiger Verlag. Ministerie van Binnenlandse Zaken en Koninkrijksrelaties. Bundeskanzlei \\\\\\\\\[Federal Chancellery of Switzerland\\\\\\\\\]. Retrieved January 1, Hidden categories: CS1 German-language sources de CS1 Dutch-language sources nl All articles with unsourced statements Articles with unsourced statements. Navigation menu Personal tools Create account Log in. Namespaces Page Discussion. Views Read View source View history. Community Network YouTube Good vibes. Summary sheet: Ethylphenidate.
Как это было, зачем, что потом и что теперь: Кратко о себе: с детства повышенная нервная возбудимость, окр (проявляющееся в потребности делать некоторые жесты по несколько раз, вроде выключения света, закрытия двери до 'идеального щелчка', разглаживания одежды на стуле). Как заверил.
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